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Sermorelin
Growth Hormone / IGF-1 AxisFDA ApprovedAlso known as: GRF 1-29
Sermorelin is a synthetic 29-amino acid analog of endogenous growth hormone-releasing hormone (GHRH 1-29). FDA-approved for pediatric growth hormone deficiency testing and treatment.
Overview
Key Takeaways
- →Natural GH pulse stimulation
- →Improved sleep quality
- →Enhanced recovery and body composition
At A Glance
Sermorelin binds the pituitary GHRH receptor and stimulates GH synthesis and release in a pulse-dependent manner that preserves the natural feedback loop. Unlike exogenous HGH, sermorelin does not suppress endogenous GH production — it restores the hypothalamic-pituitary axis toward youthful function. GH release is still regulated by somatostatin, preventing supraphysiological levels.
Sermorelin binds the pituitary GHRH receptor and stimulates GH synthesis and release in a pulse-dependent manner that preserves the natural feedback loop. Unlike exogenous HGH, sermorelin does not suppress endogenous GH production — it restores the hypothalamic-pituitary axis toward youthful function. GH release is still regulated by somatostatin, preventing supraphysiological levels.
Overview
Sermorelin is a synthetic 29-amino acid analog of endogenous growth hormone-releasing hormone (GHRH 1-29). FDA-approved for pediatric growth hormone deficiency testing and treatment. Widely used off-label in anti-aging medicine and by sports medicine physicians for GH optimization. Considered one of the safer GHRH analogs due to its physiological mechanism.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
Growth hormone-releasing hormone (1-29) amide
CAS Number
86168-78-7
Molecular Formula
C149H246N44O42S
Molecular Mass
3357.9 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Active cancer. Pituitary tumors or disorders. Pregnancy or breastfeeding. Known allergy to sermorelin or related peptides.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$39.99
up to $48.00
$7.9980
2
2
vial
| Vendor | Product | Form | Qty | Price | $/mg | Coupon | |
|---|---|---|---|---|---|---|---|
 |
Sermorelin 5mg | vial | 1 vial● In Stock | $39.99BEST | $7.998 | ||
| Sermorelin 5mg Vial | vial | 1 vial● In Stock | $48.00 | $9.600 |
Price History
2 data pointsVendors Selling Sermorelin
Related Compounds
View AllCJC-1295 (Mod GRF 1-29)
Growth Hormone / IGF-1 Axis
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.
CJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
Hexarelin
Growth Hormone / IGF-1 Axis
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.
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Protocols, calculator & safety for Sermorelin
Research Score
198 PubMed studies
Quality Indicators
Data Completeness
88%Research Credibility
Well-researched compound
Quick Facts
Molecular Weight
3357.9 g/mol
CAS Number
86168-78-7
Trial Phase
FDA Approved
Safety Profile
Low RiskCommon Side Effects
- • Injection site redness/swelling
- • Headache
- • Flushing
- • Nausea
Stop Use If
- Active malignancy
- Hypothyroidism (treat first)
- Pituitary tumor
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Sermorelin used for in research?
Sermorelin is a synthetic 29-amino acid analog of endogenous growth hormone-releasing hormone (GHRH 1-29). FDA-approved for pediatric growth hormone deficiency testing and treatment. Widely used off-label in anti-aging medicine and by sports medicine physicians for GH optimization. Considered one of the safer GHRH analogs due to its physiological mechanism.
What forms does Sermorelin come in?
Sermorelin is available in vial form.
How much does Sermorelin cost?
Prices start at $39.99 across 2 verified vendors.
How do I compare Sermorelin vendors?
Compare prices, payment methods, shipping, and COA scores across 2 vendors.
Research Tools
Related Compounds
View AllCJC-1295 (Mod GRF 1-29)
Growth Hormone / IGF-1 Axis
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.
CJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
Hexarelin
Growth Hormone / IGF-1 Axis
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.