CJC-1295 (Mod GRF 1-29) vs Sermorelin
Independent, side-by-side comparison of CJC-1295 (Mod GRF 1-29) and Sermorelin: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.
Live price snapshot
CJC-1295 (Mod GRF 1-29)
Sermorelin
CJC-1295 (Mod GRF 1-29)
CJC-1295 without DAC (also called Modified GRF 1-29 or MOD-GRF 1-29) is a 30-amino-acid analog of the first 29 residues of endogenous Growth Hormone Releasing Hormone (GHRH), with four strategic substitutions (D-Ala┬▓…
Live lowest price: $29.00 across 5 vendors
Full CJC-1295 (Mod GRF 1-29) profileSermorelin
Sermorelin acetate is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of human growth hormone-releasing hormone (GHRH 1-29). It was one of the first GHRH analogs to achieve…
Live lowest price: $24.99 across 6 vendors
Full Sermorelin profileSide-by-side comparison
| Attribute | CJC-1295 (Mod GRF 1-29) | Sermorelin |
|---|---|---|
| Category | Growth Hormone / IGF-1 Axis | Growth Hormone / IGF-1 Axis |
| Research Stage | Phase 2 (clinical development discontinued) | Preclinical |
| Mechanism of Action | MOD-GRF 1-29 exerts its effect through a single, well-characterized receptor: the GHRH receptor (GHRHR) on anterior-pituitary somatotroph cells. The signaling cascade is the same as endogenous GHRH; the difference is pharmacokinetics. 1. GHRH receptor agonism… | GHRH Receptor Pharmacology Sermorelin is a truncated analog — specifically the first 29 amino acids — of the 44-amino-acid native GHRH molecule produced by the arcuate nucleus of the hypothalamus. The 1-29 fragment retains the full biological activity of the… |
| Half-Life | ~30 minutes (without DAC / MOD-GRF 1-29); 8+ days (with DAC, due to covalent albumin binding) | — |
| Typical Dose Range | Without DAC: 100-300 mcg subcutaneous 1-3x daily (typically pre-bedtime); With DAC: 1000-2000 mcg subcutaneous once weekly | — |
| Dosing Frequency | 1–3 times daily, typically before bed and/or upon waking | — |
| Administration | Subcutaneous | — |
| Side Effects | Expected / benign - Injection-site reaction — mild redness, itching, small bump; 24-48 hour resolution - Facial flushing / warmth 15-30 min post-injection (histamine release from GHRH action); typically diminishes after week 1-2 - Mild nausea in first week at… | Common Effects - Injection site reactions — The most frequently reported issue. Mild erythema, transient itching, or a small wheal at the subcutaneous injection site. Usually self-resolves within 30-60 minutes and rarely requires intervention beyond site… |
| Molecular Weight | 3367.9 Da | 3357.9 g/mol |
| Common Vial Sizes | 2mg, 5mg | — |
Price History
2 data points- VANDL Labs
- Ion Peptide
Price History
4 data points- Unknown
- Nova Peptides
- VANDL Labs
- Ion Peptide
CJC-1295 (Mod GRF 1-29) — potential benefits
- Preserves physiologic pulsatile GH secretion
- Stimulates endogenous GH release (2-5x baseline per pulse)
- 3-5x greater GH response when stacked with ipamorelin
- Modest IGF-1 elevation (1.5-2x baseline)
- Improved sleep depth and architecture
- Enhanced recovery from exercise and injury
- Body composition improvements (lean mass preservation, modest fat loss)
- Lower desensitization risk vs CJC-1295 with DAC
Sermorelin — potential benefits
- Natural GH pulse stimulation
- Improved sleep quality
- Enhanced recovery and body composition
- Anti-aging effects
- Better skin elasticity
- Increased lean muscle mass
Frequently asked
What's the difference between CJC-1295 (Mod GRF 1-29) and Sermorelin?
CJC-1295 (Mod GRF 1-29) is a growth hormone / igf-1 axis that mod-grf 1-29 exerts its effect through a single, well-characterized receptor: the ghrh receptor (ghrhr) on anterior-pituitary somatotroph cells. the signaling cascade is the same…. Sermorelin is a growth hormone / igf-1 axis that ghrh receptor pharmacology sermorelin is a truncated analog — specifically the first 29 amino acids — of the 44-amino-acid native ghrh molecule produced by the arcuate nucleus of…. The two differ in mechanism, half-life (~30 minutes (without DAC / MOD-GRF 1-29); 8+ days (with DAC, due to covalent albumin binding) vs not reported), and typical dose range.
Which has the longer half-life, CJC-1295 (Mod GRF 1-29) or Sermorelin?
CJC-1295 (Mod GRF 1-29) has a half-life of ~30 minutes (without DAC / MOD-GRF 1-29); 8+ days (with DAC, due to covalent albumin binding). Sermorelin has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, CJC-1295 (Mod GRF 1-29) or Sermorelin?
Current lowest live price on BodyHackGuide: CJC-1295 (Mod GRF 1-29) from $29.00, Sermorelin from $24.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers.
Can you stack CJC-1295 (Mod GRF 1-29) and Sermorelin?
Stacking depends on mechanism overlap, safety profile, and goals. CJC-1295 (Mod GRF 1-29) and Sermorelin should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is an independent research reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks — this never affects the data or pricing shown. See editorial standards and affiliate disclosure.