What is a compound's half-life?

A half-life is the time it takes for the concentration of a substance in your body to reduce by 50%. After one half-life, 50% remains. After two half-lives, 25%. After five half-lives (~3.1% remaining), the compound is considered effectively cleared from the body.

Why does half-life matter for dosing?

Half-life determines how often you need to re-dose to maintain effective levels. Short half-life compounds (like Semax at ~20 minutes) require multiple daily doses, while long half-life compounds (like Semaglutide at ~168 hours) only need weekly dosing.

Where do these half-life values come from?

Our half-life data is sourced from peer-reviewed pharmacokinetic studies, clinical trial data, and pharmaceutical reference databases. For peptides, values come from published PK studies. For nootropics, values are drawn from clinical literature and manufacturer data. Each value is cited on the individual compound profile page.

Can I compare multiple compounds on the same chart?

Yes! Click 'Add compound' to overlay up to 5 compounds on the same decay chart. This is useful for timing stacked compounds: for example, seeing when BPC-157 clears while TB-500 is still active.

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Half-Life Visualizer

Compare compound concentration decay over time

Understanding half-life

After 1 half-life, 50% remains. After 2 half-lives, 25%. After 5 half-lives, less than 3.2%, effectively cleared. Compare up to 5 compounds on the same chart.

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Active Compounds

BPC-157

t½ = 30 min

Or enter custom values

Dose

Starting dose

Half-Life

hours

Time to 50% clearance

Concentration Decay (% Remaining)

BPC-157

Source: Short plasma half-life. The first formal preclinical ADME study reported an elimination half-life under ~30 minutes after IV/IM dosing in rats and dogs, with linear dose-proportional kinetics (PMID: 36588717); a 2026 biopharmaceutical review confirms this sub-30-minute plasma half-life and highlights a pharmacokinetic-pharmacodynamic disconnect, as biological effects persist for hours to days (PMID: 42198317). No full human pharmacokinetic study has been published; twice-daily dosing is empirical/community-standard rather than PK-derived.View profile

50% left

30m

25% left

1.0h

10% left

1.7h

~3% left

2.5h

How we verify half-life data

All half-life values are sourced from peer-reviewed pharmacokinetic studies and clinical trial publications. Peptide half-lives come from published phase I/II trial data and manufacturer PK profiles. Nootropic half-lives reference clinical pharmacology literature and drug monographs.

Values shown as ranges (e.g. "4-6 hours") are averaged for visualization. The raw source value is displayed in each compound's milestone card. For compounds where human PK data is limited, animal model data is used and noted accordingly.

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Half-Life Visualizer

Concentration Decay (% Remaining)

BPC-157

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