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CJC-1295 (Mod GRF 1-29)
Growth Hormone / IGF-1 AxisPreclinicalAlso known as: CJC no DAC, CJC-1295 no DAC, Modified GRF 1-29
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes. Used in research for pulsatile GH release when co-administered with a GHRP like ipamorelin.
Overview
Key Takeaways
- →GH pulse amplification
- →Body composition
- →Fat loss
- →Half-life: ~30 minutes (without DAC / mod GRF 1-29)
At A Glance
Mod GRF 1-29 binds the GHRH receptor on pituitary somatotroph cells, stimulating GH gene transcription and release. The four substitutions (A2, A8, A15, A27) protect against degradation by dipeptidyl aminopeptidase IV and other plasma peptidases. When combined with a GHRP, the dual-receptor mechanism amplifies GH output significantly beyond what either compound achieves alone — the GHRH analog increases GH pulse amplitude while the GHRP increases GH pulse frequency.
Mod GRF 1-29 binds the GHRH receptor on pituitary somatotroph cells, stimulating GH gene transcription and release. The four substitutions (A2, A8, A15, A27) protect against degradation by dipeptidyl aminopeptidase IV and other plasma peptidases. When combined with a GHRP, the dual-receptor mechanism amplifies GH output significantly beyond what either compound achieves alone — the GHRH analog increases GH pulse amplitude while the GHRP increases GH pulse frequency.
Overview
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes. Used in research for pulsatile GH release when co-administered with a GHRP like ipamorelin. Preferred over the DAC version by many researchers for its more physiological pulse pattern.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
Modified GRF(1-29) with 4 amino acid substitutions
CAS Number
863288-34-0
Molecular Formula
C165H271N47O46
Molecular Mass
3367.9 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Active cancer. Known pituitary tumors. Pregnancy or breastfeeding. Hypersensitivity to GnRH analogs.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$49.99
up to $54.99
$4.9990
2
2
blend
| Vendor | Product | Form | Qty | Price | $/mg | Coupon | |
|---|---|---|---|---|---|---|---|
 |
CJC-1295/Ipamorelin | blend | 1 vial● In Stock | $49.99BEST | $4.999 | ||
 |
CJC-1295/Ipamorelin Blend | blend | 1 vial● In Stock | $54.99 | $5.499 |
Vendors Selling CJC-1295 (Mod GRF 1-29)
Related Compounds
View AllCJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
Hexarelin
Growth Hormone / IGF-1 Axis
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.
Ipamorelin
Growth Hormone / IGF-1 Axis
Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity.
Research Score
26 PubMed studies
Quality Indicators
Data Completeness
100%COA Verification
6
Verified COAs
1
Vendors w/ COA
High verification rate (100%)
Latest test: 12/5/2024
Research Credibility
Quick Facts
Half-Life
~30 minutes (without DAC / mod GRF 1-29)
Molecular Weight
3367.9 g/mol
Administration
Subcutaneous, Intramuscular
CAS Number
863288-34-0
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Water retention
- • Headache
- • Tingling
- • Fatigue post-injection
Stop Use If
- Active malignancy
- Pituitary disorder
- Diabetic retinopathy
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is CJC-1295 (Mod GRF 1-29) used for in research?
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes. Used in research for pulsatile GH release when co-administered with a GHRP like ipamorelin. Preferred over the DAC version by many researchers for its more physiological pulse pattern.
What forms does CJC-1295 (Mod GRF 1-29) come in?
CJC-1295 (Mod GRF 1-29) is available in blend form.
How much does CJC-1295 (Mod GRF 1-29) cost?
Prices start at $49.99 across 2 verified vendors.
How do I compare CJC-1295 (Mod GRF 1-29) vendors?
Compare prices, payment methods, shipping, and COA scores across 2 vendors.
Research Tools
Related Compounds
View AllCJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
Hexarelin
Growth Hormone / IGF-1 Axis
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.
Ipamorelin
Growth Hormone / IGF-1 Axis
Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity.