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    CJC-1295 with DAC molecular structure

    CJC-1295 with DAC

    Growth Hormone / IGF-1 AxisPhase 2

    Also known as: CJC w/ DAC, CJC DAC

    CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days. This enables once or twice weekly dosing for sustained GH and IGF-1 elevation, contrasting with the pulsatile release pattern of Mod GRF 1-29..

    Half-Life: 6–8 days (due to albumin binding via DAC)Route: SubcutaneousMW: ~3647 DaCAS: 863288-34-0

    Overview

    Key Takeaways

    • →Sustained IGF-1 elevation
    • →Convenient dosing
    • →Body composition
    • →Half-life: 6–8 days (due to albumin binding via DAC)

    At A Glance

    The maleimide group in the DAC linker reacts with the free thiol of Cys34 on serum albumin, creating a long-lived reservoir that slowly releases active peptide. This produces sustained GHRH receptor stimulation rather than discrete pulses, leading to elevated baseline GH and downstream IGF-1 production. Clinical studies confirmed dose-dependent increases in IGF-1 persisting for up to 14 days after injection.

    The maleimide group in the DAC linker reacts with the free thiol of Cys34 on serum albumin, creating a long-lived reservoir that slowly releases active peptide. This produces sustained GHRH receptor stimulation rather than discrete pulses, leading to elevated baseline GH and downstream IGF-1 production. Clinical studies confirmed dose-dependent increases in IGF-1 persisting for up to 14 days after injection.

    Overview

    CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days. This enables once or twice weekly dosing for sustained GH and IGF-1 elevation, contrasting with the pulsatile release pattern of Mod GRF 1-29.

    Potential Benefits

    Sustained IGF-1 elevationConvenient dosingBody compositionAnti-agingRecovery

    Potential Research Fields

    Growth hormone deficiencyBody compositionAgingIGF-1 modulation

    Chemical Information

    IUPAC Name

    CJC-1295 with Drug Affinity Complex

    CAS Number

    863288-34-0

    Molecular Formula

    C165H271N47O46

    Molecular Mass

    3647.1 g/mol

    Dosing & Protocols

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    Research

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    Interactions

    Interaction Matrix

    Contraindications

    Active cancer. Pituitary disorders. Diabetes (GH affects insulin sensitivity). Pregnancy or breastfeeding.

    Research Disclaimer

    This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

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    Related Compounds

    View All

    CJC-1295 (Mod GRF 1-29)

    Growth Hormone / IGF-1 Axis

    CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.

    GHRP-2

    Growth Hormone / IGF-1 Axis

    GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.

    GHRP-6

    Growth Hormone / IGF-1 Axis

    GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.

    Hexarelin

    Growth Hormone / IGF-1 Axis

    Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.

    IGF-1 LR3

    Growth Hormone / IGF-1 Axis

    IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.

    Ipamorelin

    Growth Hormone / IGF-1 Axis

    Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity.

    View Full Dosage Guide →

    Protocols, calculator & safety for CJC-1295 with DAC

    Research Score

    60

    0 PubMed studies

    Quality Indicators

    Data Completeness

    75%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Studies
    Interactions
    Vendor Listings

    Quick Facts

    Half-Life

    6–8 days (due to albumin binding via DAC)

    Molecular Weight

    3647.1 g/mol

    Administration

    Subcutaneous

    CAS Number

    863288-34-0

    Trial Phase

    Phase 2

    Safety Profile

    Low Risk

    Common Side Effects

    • • Water retention
    • • Headache
    • • Injection site reactions
    • • Increased appetite

    Stop Use If

    • Active malignancy
    • Pituitary disorders
    • Uncontrolled diabetes

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is CJC-1295 with DAC used for in research?

    CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days. This enables once or twice weekly dosing for sustained GH and IGF-1 elevation, contrasting with the pulsatile release pattern of Mod GRF 1-29.

    What forms does CJC-1295 with DAC come in?

    CJC-1295 with DAC is available in vials, capsules, and sprays forms.

    How much does CJC-1295 with DAC cost?

    Pricing varies by vendor and form.

    How do I compare CJC-1295 with DAC vendors?

    Compare prices, payment methods, shipping, and COA scores across 0 vendors.

    Research Tools

    Related Compounds

    View All

    CJC-1295 (Mod GRF 1-29)

    Growth Hormone / IGF-1 Axis

    CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.

    GHRP-2

    Growth Hormone / IGF-1 Axis

    GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.

    GHRP-6

    Growth Hormone / IGF-1 Axis

    GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.

    Hexarelin

    Growth Hormone / IGF-1 Axis

    Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.

    IGF-1 LR3

    Growth Hormone / IGF-1 Axis

    IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.

    Ipamorelin

    Growth Hormone / IGF-1 Axis

    Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity.

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