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    GHRP-6 molecular structure

    GHRP-6

    Growth Hormone / IGF-1 AxisPhase 2

    Also known as: Growth Hormone RP 6

    GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied. It produces substantial GH release alongside significant appetite stimulation through ghrelin receptor activation.

    Half-Life: ~20–30 minutesRoute: Subcutaneous, IntramuscularMW: 873 DaCAS: 87616-84-0155 PubMed-Verified Studies

    Overview

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    Key Takeaways

    • →GH stimulation
    • →Appetite increase
    • →Muscle mass
    • →Half-life: ~20–30 minutes

    At A Glance

    GHRP-6 activates both GHS-R1a on somatotrophs and ghrelinergic receptors in the hypothalamus, producing dual pituitary-hypothalamic GH stimulation. The hypothalamic component involves GHRH release amplification and somatostatin suppression. Potent ghrelin receptor activation in the gut-brain axis produces the characteristic intense hunger signal. GHRP-6 also has cardioprotective properties demonstrated in rodent ischemia models through anti-apoptotic GH-independent mechanisms.

    GHRP-6 activates both GHS-R1a on somatotrophs and ghrelinergic receptors in the hypothalamus, producing dual pituitary-hypothalamic GH stimulation. The hypothalamic component involves GHRH release amplification and somatostatin suppression. Potent ghrelin receptor activation in the gut-brain axis produces the characteristic intense hunger signal. GHRP-6 also has cardioprotective properties demonstrated in rodent ischemia models through anti-apoptotic GH-independent mechanisms.

    Overview

    GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied. It produces substantial GH release alongside significant appetite stimulation through ghrelin receptor activation. Research covers GH deficiency, muscle wasting, cardiac protection, and burn treatment. The intense hunger it causes makes it less favored for fat loss but potentially useful for hard gainers.

    Potential Benefits

    GH stimulationAppetite increaseMuscle massCardiac protectionRecoveryBody composition

    Potential Research Fields

    GH deficiencyCardiac ischemiaBurn treatmentCachexia

    Chemical Information

    IUPAC Name

    H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

    CAS Number

    87616-84-0

    Molecular Formula

    C46H56N12O6

    Molecular Mass

    873.02 g/mol

    Dosing & Protocols

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    Research

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    Interactions

    Interaction Matrix

    Contraindications

    Active cancer. Diabetes. Pituitary disorders. Pregnancy or breastfeeding. Those trying to control appetite (significant hunger increase).

    Research Disclaimer

    This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

    Best Price

    $29.99

    Best $/mg

    $2.9990

    Vendors

    1

    Listings

    1

    vial

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    		 GHRP-6 10mg vial 1 vial● In Stock $29.99BEST $2.999

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    Related Compounds

    View All

    CJC-1295 (Mod GRF 1-29)

    Growth Hormone / IGF-1 Axis

    CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.

    CJC-1295 with DAC

    Growth Hormone / IGF-1 Axis

    CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.

    GHRP-2

    Growth Hormone / IGF-1 Axis

    GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.

    Hexarelin

    Growth Hormone / IGF-1 Axis

    Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.

    IGF-1 LR3

    Growth Hormone / IGF-1 Axis

    IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.

    Ipamorelin

    Growth Hormone / IGF-1 Axis

    Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity.

    View Full Dosage Guide →

    Protocols, calculator & safety for GHRP-6

    Best Price

    Limitless Biochem EU logo

    Limitless Biochem EU

    $29.99

    1 vendors · 1 listings

    Research Score

    76

    155 PubMed studies

    Quality Indicators

    Data Completeness

    100%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Studies
    Interactions
    Vendor Listings

    Research Credibility

    155PubMed studies

    Well-researched compound

    Quick Facts

    Half-Life

    ~20–30 minutes

    Molecular Weight

    873.02 g/mol

    Administration

    Subcutaneous, Intramuscular

    CAS Number

    87616-84-0

    Trial Phase

    Phase 2

    Safety Profile

    Moderate Risk

    Common Side Effects

    • • Intense hunger
    • • Cortisol elevation
    • • Water retention
    • • Lethargy
    • • Prolactin increase

    Stop Use If

    • Active malignancy
    • Insulin-resistant states
    • Cushing's syndrome

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is GHRP-6 used for in research?

    GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied. It produces substantial GH release alongside significant appetite stimulation through ghrelin receptor activation. Research covers GH deficiency, muscle wasting, cardiac protection, and burn treatment. The intense hunger it causes makes it less favored for fat loss but potentially useful for hard gainers.

    What forms does GHRP-6 come in?

    GHRP-6 is available in vial form.

    How much does GHRP-6 cost?

    Prices start at $29.99 across 1 verified vendor.

    How do I compare GHRP-6 vendors?

    Compare prices, payment methods, shipping, and COA scores across 1 vendor.

    Research Tools

    Related Compounds

    View All

    CJC-1295 (Mod GRF 1-29)

    Growth Hormone / IGF-1 Axis

    CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.

    CJC-1295 with DAC

    Growth Hormone / IGF-1 Axis

    CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.

    GHRP-2

    Growth Hormone / IGF-1 Axis

    GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.

    Hexarelin

    Growth Hormone / IGF-1 Axis

    Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.

    IGF-1 LR3

    Growth Hormone / IGF-1 Axis

    IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.

    Ipamorelin

    Growth Hormone / IGF-1 Axis

    Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity.

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