Sermorelin vs Ipamorelin
Independent, side-by-side comparison of Sermorelin and Ipamorelin: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.
Live price snapshot
Sermorelin
Ipamorelin
Sermorelin
Sermorelin acetate is a synthetic 29-amino-acid peptide corresponding to the biologically active N-terminal fragment of human growth hormone-releasing hormone (GHRH 1-29). It was one of the first GHRH analogs to achieve…
Live lowest price: $24.99 across 8 vendors
Full Sermorelin profileIpamorelin
Ipamorelin is a selective pentapeptide ghrelin receptor (GHS-R1a) agonist — one of the most studied growth hormone secretagogues (GHS) in the biohacking community and the modern companion to CJC-1295 / MOD-GRF 1-29. Its…
Live lowest price: $24.99 across 4 vendors
Full Ipamorelin profileSide-by-side comparison
| Attribute | Sermorelin | Ipamorelin |
|---|---|---|
| Category | Growth Hormone / IGF-1 Axis | Growth Hormone / IGF-1 Axis |
| Research Stage | Preclinical | Phase 2 |
| Mechanism of Action | GHRH Receptor Pharmacology Sermorelin is a truncated analog — specifically the first 29 amino acids — of the 44-amino-acid native GHRH molecule produced by the arcuate nucleus of the hypothalamus. The 1-29 fragment retains the full biological activity of the… | Ipamorelin acts as a selective agonist at the growth hormone secretagogue receptor 1a (GHS-R1a), the same receptor activated by endogenous ghrelin — the "hunger hormone" secreted primarily by P/D1 cells in the gastric fundus. The distinguishing feature of… |
| Half-Life | — | ~2 hours (plasma) |
| Typical Dose Range | — | 100-300 mcg subcutaneous 1-3x daily (most commonly 200-300 mcg pre-bedtime); often combined with CJC-1295 without DAC at 100-300 mcg |
| Dosing Frequency | — | 1–3 times daily; most commonly once at bedtime |
| Administration | — | subcutaneous, intravenous (clinical only) |
| Side Effects | Common Effects - Injection site reactions — The most frequently reported issue. Mild erythema, transient itching, or a small wheal at the subcutaneous injection site. Usually self-resolves within 30-60 minutes and rarely requires intervention beyond site… | Ipamorelin has the cleanest side-effect profile of any ghrelin-receptor agonist, which is why it dominates modern biohacking protocols. The profile is driven by (a) selective GHS-R1a agonism without cross-receptor activity, and (b) acute GH elevation (the same… |
| Molecular Weight | 3357.9 g/mol | 711.9 Da |
| Common Vial Sizes | — | 2mg, 5mg |
Price History
4 data points- BM
- Nova Peptides
- VANDL Labs
- Ion Peptide
Price History
3 data points- OF
- VANDL Labs
- Ion Peptide
Sermorelin — potential benefits
- Natural GH pulse stimulation
- Improved sleep quality
- Enhanced recovery and body composition
- Anti-aging effects
- Better skin elasticity
- Increased lean muscle mass
Ipamorelin — potential benefits
- Increased GH pulse amplitude (selective somatotroph activation)
- Elevated IGF-1 (~30-80% over baseline) with consistent dosing
- Improved slow-wave sleep architecture
- No cortisol / prolactin / ACTH elevation (unique among GHS peptides)
- Accelerated connective tissue and wound repair
- Modest lean body mass gain + fat loss in hypogonadal adults
- Enhanced recovery between training sessions
- Synergistic effect with CJC-1295 / MOD-GRF 1-29
Frequently asked
What's the difference between Sermorelin and Ipamorelin?
Sermorelin is a growth hormone / igf-1 axis that ghrh receptor pharmacology sermorelin is a truncated analog — specifically the first 29 amino acids — of the 44-amino-acid native ghrh molecule produced by the arcuate nucleus of…. Ipamorelin is a growth hormone / igf-1 axis that ipamorelin acts as a selective agonist at the growth hormone secretagogue receptor 1a (ghs-r1a), the same receptor activated by endogenous ghrelin — the "hunger hormone" secreted…. The two differ in mechanism, half-life (not reported vs ~2 hours (plasma)), and typical dose range.
Which has the longer half-life, Sermorelin or Ipamorelin?
Sermorelin has a half-life of not reported. Ipamorelin has a half-life of ~2 hours (plasma). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Sermorelin or Ipamorelin?
Current lowest live price on BodyHackGuide: Sermorelin from $24.99, Ipamorelin from $24.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers.
Can you stack Sermorelin and Ipamorelin?
Stacking depends on mechanism overlap, safety profile, and goals. Sermorelin and Ipamorelin should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is an independent research reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks — this never affects the data or pricing shown. See editorial standards and affiliate disclosure.
