Research Use Only
This site is an independent educational resource for research compounds. We do not sell, distribute, or endorse human consumption of any compound. By entering, you confirm you are 21 years of age or older and agree to our Terms & Privacy Policy.
Hexarelin
Growth Hormone / IGF-1 AxisPhase 2Also known as: Examorelin
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP. It also has unique GH-independent cardioprotective properties through direct interaction with CD36 receptors on cardiac tissue.
Overview
Key Takeaways
- →Maximum GH output
- →Cardiac protection
- →Muscle building
- →Half-life: ~70 minutes
At A Glance
Hexarelin binds GHS-R1a with the highest affinity among peptide secretagogues, producing dose-dependent GH release superior to GHRP-2 and GHRP-6. Unlike other GHRPs, it directly binds CD36 receptors on cardiac tissue, activating ERK1/2 and PI3K signaling for cardiomyocyte protection independent of GH. This dual mechanism makes hexarelin uniquely cardioprotective. Desensitization occurs more rapidly than with ipamorelin, necessitating cycling or rotating protocols.
Hexarelin binds GHS-R1a with the highest affinity among peptide secretagogues, producing dose-dependent GH release superior to GHRP-2 and GHRP-6. Unlike other GHRPs, it directly binds CD36 receptors on cardiac tissue, activating ERK1/2 and PI3K signaling for cardiomyocyte protection independent of GH. This dual mechanism makes hexarelin uniquely cardioprotective. Desensitization occurs more rapidly than with ipamorelin, necessitating cycling or rotating protocols.
Overview
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP. It also has unique GH-independent cardioprotective properties through direct interaction with CD36 receptors on cardiac tissue. Research spans GH deficiency treatment, cardiac protection post-ischemia, and body composition optimization.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH2
CAS Number
140703-51-1
Molecular Formula
C47H58N12O6
Molecular Mass
887.05 g/mol
Dosing & Protocols
Unlock Dosing Protocols
Create a free account to:
- View beginner, intermediate & advanced protocols
- See weight-based dosing calculations
- Access cycle length & frequency data
Join 2,800+ researchers
Research
Unlock Research Data
Create a free account to:
- Browse PubMed study summaries
- See clinical trial phases & results
- Access mechanism of action details
Join 2,800+ researchers
Interactions
Interaction Matrix
Contraindications
Active cancer. Pituitary disorders. Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$44.99
$4.4990
1
1
vial
Vendors Selling Hexarelin
Related Compounds
View AllCJC-1295 (Mod GRF 1-29)
Growth Hormone / IGF-1 Axis
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.
CJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.
Ipamorelin
Growth Hormone / IGF-1 Axis
Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity.
View Full Dosage Guide →
Protocols, calculator & safety for Hexarelin
Research Score
14 PubMed studies
Quality Indicators
Data Completeness
100%Research Credibility
Quick Facts
Half-Life
~70 minutes
Molecular Weight
887.05 g/mol
Administration
Subcutaneous, Intramuscular
CAS Number
140703-51-1
Trial Phase
Phase 2
Safety Profile
Moderate RiskCommon Side Effects
- • Cortisol and prolactin elevation
- • Water retention
- • Fatigue
- • Hunger
Stop Use If
- Active malignancy
- Uncontrolled cardiovascular disease
- Cushing's syndrome
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Hexarelin used for in research?
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP. It also has unique GH-independent cardioprotective properties through direct interaction with CD36 receptors on cardiac tissue. Research spans GH deficiency treatment, cardiac protection post-ischemia, and body composition optimization.
What forms does Hexarelin come in?
Hexarelin is available in vial form.
How much does Hexarelin cost?
Prices start at $44.99 across 1 verified vendor.
How do I compare Hexarelin vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View AllCJC-1295 (Mod GRF 1-29)
Growth Hormone / IGF-1 Axis
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.
CJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.
Ipamorelin
Growth Hormone / IGF-1 Axis
Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity.