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Ipamorelin
Growth Hormone / IGF-1 AxisPreclinicalAlso known as: Ipam, IPA
Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity. Unlike earlier GHRPs, ipamorelin produces minimal cortisol, prolactin, or ACTH release, making it among the cleanest GH secretagogues available.
Overview
Key Takeaways
- →GH pulse amplification
- →Fat loss
- →Muscle preservation
- →Half-life: ~2 hours
At A Glance
Ipamorelin selectively binds the growth hormone secretagogue receptor 1a (GHSR-1a) in the pituitary gland, stimulating a pulsatile burst of endogenous growth hormone release. The selectivity for GHSR-1a over other receptors explains its clean side effect profile — it does not significantly activate pathways that raise cortisol or prolactin as GHRP-2 and GHRP-6 do. GH release is amplified when co-administered with a GHRH analog (CJC-1295 or sermorelin) through a dual-receptor synergy mechanism.
Ipamorelin selectively binds the growth hormone secretagogue receptor 1a (GHSR-1a) in the pituitary gland, stimulating a pulsatile burst of endogenous growth hormone release. The selectivity for GHSR-1a over other receptors explains its clean side effect profile — it does not significantly activate pathways that raise cortisol or prolactin as GHRP-2 and GHRP-6 do. GH release is amplified when co-administered with a GHRH analog (CJC-1295 or sermorelin) through a dual-receptor synergy mechanism.
Overview
Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity. Unlike earlier GHRPs, ipamorelin produces minimal cortisol, prolactin, or ACTH release, making it among the cleanest GH secretagogues available. Research focuses on GH pulse amplification, body composition, sleep quality, and recovery.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
Aib-His-D-2-Nal-D-Phe-Lys-NH2
CAS Number
170851-70-4
Molecular Formula
C38H49N9O5
Molecular Mass
711.86 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Active cancer. Pituitary tumors. Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$34.99
$6.9980
1
1
vial
Vendors Selling Ipamorelin
Related Compounds
View AllCJC-1295 (Mod GRF 1-29)
Growth Hormone / IGF-1 Axis
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.
CJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
Hexarelin
Growth Hormone / IGF-1 Axis
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.
Research Score
11 PubMed studies
Quality Indicators
Data Completeness
100%Research Credibility
Quick Facts
Half-Life
~2 hours
Molecular Weight
711.86 g/mol
Administration
Subcutaneous, Intramuscular
CAS Number
170851-70-4
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Water retention (transient)
- • Mild lethargy
- • Increased appetite
- • Tingling (extremities)
Stop Use If
- Active malignancy — GH stimulation contraindicated
- Pituitary tumor history
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Ipamorelin used for in research?
Ipamorelin is a selective pentapeptide growth hormone secretagogue that mimics ghrelin at the GHSR-1a receptor with high selectivity. Unlike earlier GHRPs, ipamorelin produces minimal cortisol, prolactin, or ACTH release, making it among the cleanest GH secretagogues available. Research focuses on GH pulse amplification, body composition, sleep quality, and recovery.
What forms does Ipamorelin come in?
Ipamorelin is available in vial form.
How much does Ipamorelin cost?
Prices start at $34.99 across 1 verified vendor.
How do I compare Ipamorelin vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View AllCJC-1295 (Mod GRF 1-29)
Growth Hormone / IGF-1 Axis
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.
CJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
Hexarelin
Growth Hormone / IGF-1 Axis
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.