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    CJC-1295 (Mod GRF 1-29) vs Ipamorelin

    Independent, side-by-side comparison of CJC-1295 (Mod GRF 1-29) and Ipamorelin: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.

    CJC-1295 (Mod GRF 1-29) from $29.00
    Ipamorelin from $24.99

    Live price snapshot

    CJC-1295 (Mod GRF 1-29)

    Current low
    $49.00
    as of Apr 22, 2026
    7-day low
    —
    no 7d data yet
    30-day low
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    no 30d data yet
    30-day change
    —
    baseline building

    Ipamorelin

    Current low
    $42.00
    as of Apr 22, 2026
    7-day low
    —
    no 7d data yet
    30-day low
    —
    no 30d data yet
    30-day change
    —
    baseline building

    CJC-1295 (Mod GRF 1-29)

    Featured

    CJC-1295 without DAC (also called Modified GRF 1-29 or MOD-GRF 1-29) is a 30-amino-acid analog of the first 29 residues of endogenous Growth Hormone Releasing Hormone (GHRH), with four strategic substitutions (D-Ala² for…

    Live lowest price: $29.00 across 6 vendors

    Full CJC-1295 (Mod GRF 1-29) profile

    Ipamorelin

    Ipamorelin is a selective pentapeptide ghrelin receptor (GHS-R1a) agonist — one of the most studied growth hormone secretagogues (GHS) in the biohacking community and the modern companion to CJC-1295 / MOD-GRF 1-29. Its…

    Live lowest price: $24.99 across 4 vendors

    Full Ipamorelin profile

    Side-by-side comparison

    Attribute CJC-1295 (Mod GRF 1-29) Ipamorelin
    Category Growth Hormone / IGF-1 Axis Growth Hormone / IGF-1 Axis
    Research Stage Phase 2 (clinical development discontinued) Phase 2
    Mechanism of Action MOD-GRF 1-29 exerts its effect through a single, well-characterized receptor: the GHRH receptor (GHRHR) on anterior-pituitary somatotroph cells. The signaling cascade is the same as endogenous GHRH; the difference is pharmacokinetics. 1. GHRH receptor agonism… Ipamorelin acts as a selective agonist at the growth hormone secretagogue receptor 1a (GHS-R1a), the same receptor activated by endogenous ghrelin — the "hunger hormone" secreted primarily by P/D1 cells in the gastric fundus. The distinguishing feature of…
    Half-Life ~30 minutes (without DAC / MOD-GRF 1-29); 8+ days (with DAC, due to covalent albumin binding) ~2 hours (plasma)
    Typical Dose Range Without DAC: 100-300 mcg subcutaneous 1-3x daily (typically pre-bedtime); With DAC: 1000-2000 mcg subcutaneous once weekly 100-300 mcg subcutaneous 1-3x daily (most commonly 200-300 mcg pre-bedtime); often combined with CJC-1295 without DAC at 100-300 mcg
    Dosing Frequency 1–3 times daily, typically before bed and/or upon waking 1–3 times daily; most commonly once at bedtime
    Administration Subcutaneous subcutaneous, intravenous (clinical only)
    Side Effects Expected / benign - Injection-site reaction — mild redness, itching, small bump; 24-48 hour resolution - Facial flushing / warmth 15-30 min post-injection (histamine release from GHRH action); typically diminishes after week 1-2 - Mild nausea in first week at… Ipamorelin has the cleanest side-effect profile of any ghrelin-receptor agonist, which is why it dominates modern biohacking protocols. The profile is driven by (a) selective GHS-R1a agonism without cross-receptor activity, and (b) acute GH elevation (the same…
    Molecular Weight 3367.9 Da 711.9 Da
    Common Vial Sizes 2mg, 5mg 2mg, 5mg

    Price History

    2 data points
    • VANDL Labs
    • Ion Peptide

    Price History

    3 data points
    • OF
    • VANDL Labs
    • Ion Peptide

    CJC-1295 (Mod GRF 1-29) — potential benefits

    • Preserves physiologic pulsatile GH secretion
    • Stimulates endogenous GH release (2-5x baseline per pulse)
    • 3-5x greater GH response when stacked with ipamorelin
    • Modest IGF-1 elevation (1.5-2x baseline)
    • Improved sleep depth and architecture
    • Enhanced recovery from exercise and injury
    • Body composition improvements (lean mass preservation, modest fat loss)
    • Lower desensitization risk vs CJC-1295 with DAC

    Ipamorelin — potential benefits

    • Increased GH pulse amplitude (selective somatotroph activation)
    • Elevated IGF-1 (~30-80% over baseline) with consistent dosing
    • Improved slow-wave sleep architecture
    • No cortisol / prolactin / ACTH elevation (unique among GHS peptides)
    • Accelerated connective tissue and wound repair
    • Modest lean body mass gain + fat loss in hypogonadal adults
    • Enhanced recovery between training sessions
    • Synergistic effect with CJC-1295 / MOD-GRF 1-29
    In-depth comparison

    CJC-1295 (Mod GRF 1-29) vs Ipamorelin: the long answer

    CJC-1295 is a GHRH analog — it primes the pituitary to release more GH per pulse. Ipamorelin is a ghrelin-receptor agonist — it triggers the GH pulse itself. They're NOT a 'vs' choice; they're a stack. Pulse amplitude (CJC-1295) × pulse trigger (ipamorelin) produces the largest sustained GH/IGF-1 lift in the secretagogue class. Solo use of either gets you ~50% of stack effect.

    Last reviewed: May 18, 2026

    Mechanism — different levers, both needed

    CJC-1295 binds the GHRH receptor on the pituitary's somatotroph cells, increasing the AMOUNT of GH released when a release signal arrives. Ipamorelin binds the ghrelin receptor (GHS-R1a) and IS the release signal — it triggers a clean GH pulse with no cortisol or prolactin elevation (unlike older GHRPs). Run CJC-1295 alone and you've amplified a signal nobody's firing. Run ipamorelin alone and you're firing pulses on stock-amplitude somatotrophs. Stack them and the same pulse releases 2-3× more GH.

    • CJC-1295: GHRH analog. Increases GH release AMOUNT per pulse.
    • Ipamorelin: Ghrelin-receptor agonist. Triggers the pulse itself.
    • Why stack: Pulse amplitude × pulse trigger = 2-3× larger GH spike than either solo. Same IGF-1 lift, lower total mg dosed.

    CJC-1295 — DAC vs no-DAC matters

    Two versions exist: CJC-1295 with DAC (drug affinity complex) has a 6-8 day half-life — one dose lasts a week, creates sustained GH bleed. CJC-1295 without DAC (sometimes called "modified GRF 1-29" or "Mod GRF") has a 30-minute half-life — must be dosed alongside each ipamorelin shot. For pulsatile-mimicking protocols (closer to natural GH rhythm), use no-DAC. For convenience or longevity-focused continuous-elevation protocols, use DAC. The trade-off: continuous GH elevation may cause receptor desensitization over months; pulsatile preserves sensitivity.

    • CJC-1295 (no DAC): Half-life ~30 min. Dose with each ipamorelin shot. Mimics natural pulsatile rhythm.
    • CJC-1295 + DAC: Half-life 6-8 days. Once-weekly. Continuous GH elevation — more convenient, possibly higher desensitization risk.

    Dosing — the standard stack protocol

    Most-published protocol: CJC-1295 no-DAC 100 mcg + ipamorelin 100-300 mcg, both subQ, 2-3× daily. Time at least 90 min after meals (food disrupts the GH pulse). Bedtime dose is canonical — aligns with natural overnight GH peak. Loading phase 4-8 weeks, then maintenance at 1×/day pre-bed for ongoing effect. For DAC variant: CJC-1295 DAC 1-2 mg once weekly + ipamorelin 300 mcg 2-3× daily.

    • Standard stack (no-DAC): CJC 100mcg + ipam 100-300mcg, 2-3×/day, subQ, fasted
    • DAC variant: CJC DAC 1-2mg 1×/week + ipam 300mcg 2-3×/day
    • Bedtime is non-negotiable: Aligns with natural overnight GH peak. Skip at your own loss.

    Safety — clean profile, watch site irritation

    Ipamorelin alone has perhaps the cleanest side-effect profile of any GH secretagogue — no cortisol, no prolactin, no appetite spike. CJC-1295 adds modest injection-site irritation (1-2 day red welts) and occasional facial flushing in the first 2 weeks. No published cancer-promotion signals despite long-term use in published Phase 2 trials. Both share the standard GH-axis warnings: not for active malignancy, monitor IGF-1 quarterly at high doses, avoid in active diabetic retinopathy.

    • Ipamorelin profile: Cleanest GH secretagogue. No cortisol/prolactin elevation.
    • CJC-1295 side effects: Injection-site welts (1-2 day), occasional facial flushing weeks 1-2. Both fade.
    • Monitor at high doses: IGF-1 quarterly if running stack >6 months at high dose. Standard GH-axis caution applies.

    Cost — both cheap research-use

    Research-use CJC-1295 no-DAC ~$15-30/5mg vial → ~$3-6/week at 100mcg 3×/day. CJC-1295 DAC ~$25-50/2mg vial → ~$10-25/week. Ipamorelin ~$20-40/5mg vial → ~$3-7/week at 300mcg 3×/day. Full stack: $6-30/week depending on DAC choice + dosing intensity. Compared to recombinant GH ($300-500/month), the stack is 50-100× cheaper for similar IGF-1 lift.

    • CJC-1295 no-DAC cost: $15-30/5mg vial → $3-6/week
    • CJC-1295 DAC cost: $25-50/2mg vial → $10-25/week
    • Ipamorelin cost: $20-40/5mg vial → $3-7/week
    • Full stack vs HGH: Stack: $6-30/week. Recombinant HGH: $300-500/month. 50-100× cheaper for similar IGF-1.

    Who runs which

    Run ipamorelin alone if you just want sleep quality + modest recovery + zero injection-site issues. Run CJC-1295 alone — don't, it's wasteful. Run the stack if you want maximum IGF-1 lift, body recomposition support, or are targeting GH-deficient symptoms (low energy, slow recovery, sleep fragmentation in older users). DAC variant for convenience + budget. No-DAC for purist pulsatile-mimicking protocols.

    • Solo ipamorelin: Sleep + modest recovery, lowest cost, simplest
    • Solo CJC-1295: Wasteful — no signal to amplify. Don't
    • Stack (preferred): Max IGF-1 lift. Choose DAC for convenience or no-DAC for pulse fidelity

    Frequently asked

    What's the difference between CJC-1295 (Mod GRF 1-29) and Ipamorelin?

    CJC-1295 (Mod GRF 1-29) is a growth hormone / igf-1 axis that mod-grf 1-29 exerts its effect through a single, well-characterized receptor: the ghrh receptor (ghrhr) on anterior-pituitary somatotroph cells. the signaling cascade is the same…. Ipamorelin is a growth hormone / igf-1 axis that ipamorelin acts as a selective agonist at the growth hormone secretagogue receptor 1a (ghs-r1a), the same receptor activated by endogenous ghrelin — the "hunger hormone" secreted…. The two differ in mechanism, half-life (~30 minutes (without DAC / MOD-GRF 1-29); 8+ days (with DAC, due to covalent albumin binding) vs ~2 hours (plasma)), and typical dose range.

    Which has the longer half-life, CJC-1295 (Mod GRF 1-29) or Ipamorelin?

    CJC-1295 (Mod GRF 1-29) has a half-life of ~30 minutes (without DAC / MOD-GRF 1-29); 8+ days (with DAC, due to covalent albumin binding). Ipamorelin has a half-life of ~2 hours (plasma). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.

    Which is cheaper, CJC-1295 (Mod GRF 1-29) or Ipamorelin?

    Current lowest live price on BodyHackGuide: CJC-1295 (Mod GRF 1-29) from $29.00, Ipamorelin from $24.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers.

    Can you stack CJC-1295 (Mod GRF 1-29) and Ipamorelin?

    Stacking depends on mechanism overlap, safety profile, and goals. CJC-1295 (Mod GRF 1-29) and Ipamorelin should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.

    Should I take CJC-1295 with or without DAC?

    No-DAC for pulsatile mimicking and convenience-flexible dosers. DAC for once-weekly convenience and continuous GH elevation. No-DAC is the purist choice — it matches the natural overnight GH peak when timed with bedtime ipamorelin. DAC is fine for users who don't want to dose 2-3× daily.

    Can I run CJC-1295 alone?

    You can, but it's mostly wasted. CJC-1295 amplifies GH release per pulse — it doesn't trigger pulses. Without ipamorelin (or another ghrelin agonist like MK-677), you're just increasing the amplitude of GH pulses your body already releases naturally. The stack with ipamorelin produces 2-3× the IGF-1 lift of CJC-1295 alone.

    How long does it take to see results from CJC-1295 + ipamorelin?

    Sleep quality improves within 3-5 days (most users notice deeper sleep, better dreams). Body composition + recovery effects show in 4-6 weeks. Full IGF-1 elevation peaks around week 8 of consistent dosing. Most users run the stack in 12-week cycles with 4-week breaks.

    Do I need to cycle CJC-1295 + ipamorelin?

    Cycling isn't strictly required but recommended. Standard pattern: 12 weeks on, 4 weeks off, repeat. The receptor sensitivity argument for cycling is stronger for continuous-elevation protocols (DAC variant). Pulsatile protocols (no-DAC) preserve sensitivity better and may not need breaks.

    Can I add MK-677 to a CJC-1295 + ipamorelin stack?

    Technically yes — MK-677 is also a ghrelin-receptor agonist but works orally with 24-hour half-life. Stacking it with ipamorelin adds receptor saturation without proportional benefit. Better: pick one ghrelin pathway. MK-677 + CJC-1295 (no ipamorelin) is a clean oral + injectable hybrid. Or stick with ipamorelin + CJC-1295 for the purist injectable stack.

    What's the difference between Ipamorelin + CJC-1295 stack and Sermorelin?

    Sermorelin is just GHRH (1-29 fragment) — basically a less-engineered version of CJC-1295 no-DAC. Stacking sermorelin with ipamorelin works but you're getting less amplitude lift per mg than with CJC-1295. CJC-1295 no-DAC superseded sermorelin in most published protocols around 2015-2018.

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    CJC-1295 (Mod GRF 1-29) prices Ipamorelin prices Compare all compounds

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    Related comparisons

    Ipamorelin vs MK-677Tesamorelin vs CJC-1295Sermorelin vs IpamorelinMK-677 vs CJC-1295Hexarelin vs IpamorelinIGF-1-LR3 vs IpamorelinCJC-1295-Dac vs CJC-1295GHRP-2 vs Ipamorelin

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