IGF-1 LR3 vs Ipamorelin
Independent, side-by-side comparison of IGF-1 LR3 and Ipamorelin: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.
Live price snapshot
IGF-1 LR3
Ipamorelin
IGF-1 LR3
IGF-1 LR3 (Long R3 IGF-1) is a synthetic analog of human insulin-like growth factor 1 modified at two positions to dramatically extend its serum half-life and amplify its tissue bioactivity compared to native IGF-1. The…
Live lowest price: $49.99 across 5 vendors
Full IGF-1 LR3 profileIpamorelin
Ipamorelin is a selective pentapeptide ghrelin receptor (GHS-R1a) agonist — one of the most studied growth hormone secretagogues (GHS) in the biohacking community and the modern companion to CJC-1295 / MOD-GRF 1-29. Its…
Live lowest price: $24.99 across 4 vendors
Full Ipamorelin profileSide-by-side comparison
| Attribute | IGF-1 LR3 | Ipamorelin |
|---|---|---|
| Category | Growth Hormone / IGF-1 Axis | Growth Hormone / IGF-1 Axis |
| Research Stage | Preclinical | Phase 2 |
| Mechanism of Action | IGF-1 Receptor Signaling IGF-1 LR3 binds the IGF-1 receptor (IGF1R) — a transmembrane receptor tyrosine kinase expressed on virtually every cell type in the human body. IGF1R activation triggers two principal intracellular signaling cascades: PI3K / Akt / mTOR… | Ipamorelin acts as a selective agonist at the growth hormone secretagogue receptor 1a (GHS-R1a), the same receptor activated by endogenous ghrelin — the "hunger hormone" secreted primarily by P/D1 cells in the gastric fundus. The distinguishing feature of… |
| Half-Life | 20–30 hours (vs 12–15 minutes for native IGF-1) | ~2 hours (plasma) |
| Typical Dose Range | 20–100 mcg per day | 100-300 mcg subcutaneous 1-3x daily (most commonly 200-300 mcg pre-bedtime); often combined with CJC-1295 without DAC at 100-300 mcg |
| Dosing Frequency | Once daily, typically post-workout or in the morning | 1–3 times daily; most commonly once at bedtime |
| Administration | Subcutaneous, Intramuscular | subcutaneous, intravenous (clinical only) |
| Side Effects | Acute and Common - Hypoglycemia — The primary acute safety concern. Post-injection blood glucose drops can produce shakiness, sweating, confusion, palpitations, and in severe cases loss of consciousness. Mitigation: 30-40g of fast-digesting carbohydrate within… | Ipamorelin has the cleanest side-effect profile of any ghrelin-receptor agonist, which is why it dominates modern biohacking protocols. The profile is driven by (a) selective GHS-R1a agonism without cross-receptor activity, and (b) acute GH elevation (the same… |
| Molecular Weight | 9117 Da | 711.9 Da |
| Common Vial Sizes | 100mcg, 1mg | 2mg, 5mg |
Price History
5 data points- OF
- Nova Peptides
- VANDL Labs
- Unknown
- Ion Peptide
Price History
3 data points- OF
- VANDL Labs
- Ion Peptide
IGF-1 LR3 — potential benefits
- Muscle hypertrophy
- Recovery
- Protein synthesis
- Fat metabolism
- Glucose uptake
Ipamorelin — potential benefits
- Increased GH pulse amplitude (selective somatotroph activation)
- Elevated IGF-1 (~30-80% over baseline) with consistent dosing
- Improved slow-wave sleep architecture
- No cortisol / prolactin / ACTH elevation (unique among GHS peptides)
- Accelerated connective tissue and wound repair
- Modest lean body mass gain + fat loss in hypogonadal adults
- Enhanced recovery between training sessions
- Synergistic effect with CJC-1295 / MOD-GRF 1-29
Frequently asked
What's the difference between IGF-1 LR3 and Ipamorelin?
IGF-1 LR3 is a growth hormone / igf-1 axis that igf-1 receptor signaling igf-1 lr3 binds the igf-1 receptor (igf1r) — a transmembrane receptor tyrosine kinase expressed on virtually every cell type in the human body. igf1r…. Ipamorelin is a growth hormone / igf-1 axis that ipamorelin acts as a selective agonist at the growth hormone secretagogue receptor 1a (ghs-r1a), the same receptor activated by endogenous ghrelin — the "hunger hormone" secreted…. The two differ in mechanism, half-life (20–30 hours (vs 12–15 minutes for native IGF-1) vs ~2 hours (plasma)), and typical dose range.
Which has the longer half-life, IGF-1 LR3 or Ipamorelin?
IGF-1 LR3 has a half-life of 20–30 hours (vs 12–15 minutes for native IGF-1). Ipamorelin has a half-life of ~2 hours (plasma). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, IGF-1 LR3 or Ipamorelin?
Current lowest live price on BodyHackGuide: IGF-1 LR3 from $49.99, Ipamorelin from $24.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers.
Can you stack IGF-1 LR3 and Ipamorelin?
Stacking depends on mechanism overlap, safety profile, and goals. IGF-1 LR3 and Ipamorelin should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is an independent research reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks — this never affects the data or pricing shown. See editorial standards and affiliate disclosure.
