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DSIP (Delta Sleep-Inducing Peptide)
Cognition, Mood & NeuroprotectionPreclinicalAlso known as: Delta Sleep
DSIP is an endogenous nonapeptide first isolated from rabbit cerebral venous blood in 1977. As its name suggests, it was originally identified for its ability to induce delta sleep patterns.
Overview
Key Takeaways
- →Sleep induction
- →Stress reduction
- →Cortisol modulation
- →Half-life: ~7–8 minutes IV (short, but sleep-promoting effects last hours)
At A Glance
DSIP acts on multiple receptor systems including opioidergic, serotonergic, and GABAergic pathways to promote slow-wave (delta) sleep. It modulates the hypothalamic-pituitary-adrenal axis by reducing ACTH-stimulated cortisol release, offering stress-buffering effects. It also appears to modulate the gonadotropic axis and may influence GH release patterns. The peptide crosses the blood-brain barrier through saturable transport mechanisms.
DSIP acts on multiple receptor systems including opioidergic, serotonergic, and GABAergic pathways to promote slow-wave (delta) sleep. It modulates the hypothalamic-pituitary-adrenal axis by reducing ACTH-stimulated cortisol release, offering stress-buffering effects. It also appears to modulate the gonadotropic axis and may influence GH release patterns. The peptide crosses the blood-brain barrier through saturable transport mechanisms.
Overview
DSIP is an endogenous nonapeptide first isolated from rabbit cerebral venous blood in 1977. As its name suggests, it was originally identified for its ability to induce delta sleep patterns. Research has since expanded to stress modulation, cortisol regulation, opioid tolerance reduction, and potential neuroprotective applications.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
CAS Number
62568-57-4
Molecular Formula
C35H48N10O15
Molecular Mass
848.81 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Severe hypotension. Narcolepsy. Pregnancy or breastfeeding. Concurrent sedative use.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$29.99
up to $35.00
$5.9980
4
4
vial, strip
Price History
2 data pointsVendors Selling DSIP (Delta Sleep-Inducing Peptide)
Research Score
518 PubMed studies
Quality Indicators
Data Completeness
100%Research Credibility
Well-researched compound
Quick Facts
Half-Life
~7–8 minutes IV (short, but sleep-promoting effects last hours)
Molecular Weight
848.81 g/mol
Administration
Subcutaneous, Intramuscular, Intranasal
CAS Number
62568-57-4
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Morning grogginess (high doses)
- • Vivid dreams
- • Mild headache
Stop Use If
- Insufficient data for pregnancy/breastfeeding
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is DSIP (Delta Sleep-Inducing Peptide) used for in research?
DSIP is an endogenous nonapeptide first isolated from rabbit cerebral venous blood in 1977. As its name suggests, it was originally identified for its ability to induce delta sleep patterns. Research has since expanded to stress modulation, cortisol regulation, opioid tolerance reduction, and potential neuroprotective applications.
What forms does DSIP (Delta Sleep-Inducing Peptide) come in?
DSIP (Delta Sleep-Inducing Peptide) is available in vial, strip forms.
How much does DSIP (Delta Sleep-Inducing Peptide) cost?
Prices start at $29.99 across 4 verified vendors.
How do I compare DSIP (Delta Sleep-Inducing Peptide) vendors?
Compare prices, payment methods, shipping, and COA scores across 4 vendors.