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TB-500 (Thymosin Beta-4)
Injury, Repair & RecoveryPhase 2Also known as: Thymosin Beta-4, TB4, TB 500
TB-500 is a synthetic fragment of the naturally occurring peptide Thymosin Beta-4, a ubiquitous protein found in virtually all human and animal cells. Research centers on its role in actin regulation, wound healing, angiogenesis, cardiac repair, and anti-inflammatory effects.
Overview
Key Takeaways
- βAccelerated wound healing and tissue repair
- βReduced inflammation and fibrosis
- βEnhanced flexibility and mobility
- βHalf-life: ~2β3 hours
At A Glance
TB-500 sequesters G-actin monomers through its Actin Binding Domain (LKKTETQ sequence), regulating actin polymerization dynamics. This fundamentally alters cell migration by enabling rapid cytoskeletal reorganization in response to injury signals. It simultaneously upregulates metalloproteinases for extracellular matrix remodeling and promotes endothelial cell migration via PI3K/Akt and eNOS pathways, driving angiogenesis at wound sites. It also downregulates inflammatory cytokines including IL-1Ξ² and TNF-Ξ±.
TB-500 sequesters G-actin monomers through its Actin Binding Domain (LKKTETQ sequence), regulating actin polymerization dynamics. This fundamentally alters cell migration by enabling rapid cytoskeletal reorganization in response to injury signals. It simultaneously upregulates metalloproteinases for extracellular matrix remodeling and promotes endothelial cell migration via PI3K/Akt and eNOS pathways, driving angiogenesis at wound sites. It also downregulates inflammatory cytokines including IL-1Ξ² and TNF-Ξ±.
Overview
TB-500 is a synthetic fragment of the naturally occurring peptide Thymosin Beta-4, a ubiquitous protein found in virtually all human and animal cells. Research centers on its role in actin regulation, wound healing, angiogenesis, cardiac repair, and anti-inflammatory effects. Clinical trials have explored its use in cardiac and ophthalmic indications.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
Thymosin beta-4 (16β23 fragment)
CAS Number
77591-33-4
Molecular Formula
C212H350N56O78S
Molecular Mass
4963.5 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Active cancer (theoretical concern with tissue growth promotion). Pregnancy or breastfeeding. Known hypersensitivity to thymosin beta-4 fragments.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$34.99
up to $59.99
$5.9990
4
4
vial
Price History
2 data pointsVendors Selling TB-500 (Thymosin Beta-4)
Research Score
1038 PubMed studies
Quality Indicators
Data Completeness
100%COA Verification
6
Verified COAs
1
Vendors w/ COA
High verification rate (100%)
Latest test: 12/5/2024
Research Credibility
Well-researched compound
Quick Facts
Half-Life
~2β3 hours
Molecular Weight
4963.5 g/mol
Administration
Subcutaneous, Intramuscular
CAS Number
77591-33-4
Trial Phase
Phase 2
Safety Profile
Low RiskCommon Side Effects
- β’ Mild lethargy post-injection
- β’ Headache
- β’ Injection site redness
Stop Use If
- Signs of allergic reaction
- Tumor growth history β consult physician
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is TB-500 (Thymosin Beta-4) used for in research?
TB-500 is a synthetic fragment of the naturally occurring peptide Thymosin Beta-4, a ubiquitous protein found in virtually all human and animal cells. Research centers on its role in actin regulation, wound healing, angiogenesis, cardiac repair, and anti-inflammatory effects. Clinical trials have explored its use in cardiac and ophthalmic indications.
What forms does TB-500 (Thymosin Beta-4) come in?
TB-500 (Thymosin Beta-4) is available in vial form.
How much does TB-500 (Thymosin Beta-4) cost?
Prices start at $34.99 across 4 verified vendors.
How do I compare TB-500 (Thymosin Beta-4) vendors?
Compare prices, payment methods, shipping, and COA scores across 4 vendors.