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Epithalon
Longevity & Cellular HealthPreclinicalAlso known as: Epitalon
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural pineal gland peptide epithalamin, developed by Russian gerontologist Dr. Vladimir Khavinson.
Overview
Key Takeaways
- →Telomere elongation
- →Melatonin regulation
- →Anti-aging
- →Half-life: ~10–15 minutes (but telomerase activation effects persist)
At A Glance
Epithalon activates telomerase (hTERT) in somatic cells, enabling the elongation of telomere caps at chromosome ends. Telomere shortening is a key hallmark of cellular aging — each cell division erodes telomeres until replicative senescence. By restoring telomerase activity, epithalon may extend the replicative lifespan of cells. It also regulates pineal gland function and melatonin production, which decline with age. Studies in rodents showed 13–18% increase in maximum lifespan.
Epithalon activates telomerase (hTERT) in somatic cells, enabling the elongation of telomere caps at chromosome ends. Telomere shortening is a key hallmark of cellular aging — each cell division erodes telomeres until replicative senescence. By restoring telomerase activity, epithalon may extend the replicative lifespan of cells. It also regulates pineal gland function and melatonin production, which decline with age. Studies in rodents showed 13–18% increase in maximum lifespan.
Overview
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural pineal gland peptide epithalamin, developed by Russian gerontologist Dr. Vladimir Khavinson. Research focuses on its telomerase activation, pineal gland regulation, melatonin normalization, and potential life extension properties. Khavinson's group reported significant lifespan extension in animal studies and improvements in various aging biomarkers in human trials.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
L-alanyl-L-alpha-glutamyl-L-alpha-aspartylglycine
CAS Number
307297-39-8
Molecular Formula
C14H22N4O9
Molecular Mass
390.35 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Pregnancy or breastfeeding. Known autoimmune disorders affecting the telomere system. Active cancer (theoretical concern with cell replication enhancement).
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
Research Score
1 PubMed studies
Quality Indicators
Data Completeness
100%Research Credibility
Limited research available
Quick Facts
Half-Life
~10–15 minutes (but telomerase activation effects persist)
Molecular Weight
390.35 g/mol
Administration
Subcutaneous, Intramuscular
CAS Number
307297-39-8
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Mild injection site discomfort
- • Improved sleep (melatonin modulation)
- • Vivid dreams
Stop Use If
- Active malignancy — telomerase activation may promote tumor cell immortalization
- Insufficient long-term safety data
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Epithalon used for in research?
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural pineal gland peptide epithalamin, developed by Russian gerontologist Dr. Vladimir Khavinson. Research focuses on its telomerase activation, pineal gland regulation, melatonin normalization, and potential life extension properties. Khavinson's group reported significant lifespan extension in animal studies and improvements in various aging biomarkers in human trials.
What forms does Epithalon come in?
Epithalon is available in vial form.
How much does Epithalon cost?
Prices start at $34.99 across 1 verified vendor.
How do I compare Epithalon vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.