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Alpha-GPC
NootropicsPhase 4Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat. It is the most bioavailable oral choline source, efficiently crossing the blood-brain barrier to increase acetylcholine synthesis.
Overview
Key Takeaways
- →Acetylcholine elevation
- →Memory and learning
- →Focus
At A Glance
Alpha-GPC is hydrolyzed in the gut to glycerophosphocholine, which crosses the blood-brain barrier and is further metabolized to provide free choline for acetylcholine synthesis via choline acetyltransferase. Unlike choline bitartrate, the phospholipid structure of Alpha-GPC dramatically improves bioavailability and preferential delivery to neural tissue. It also directly increases neuronal membrane phospholipid content, supporting structural integrity. Several studies show it increases growth hormone release when taken pre-exercise.
Alpha-GPC is hydrolyzed in the gut to glycerophosphocholine, which crosses the blood-brain barrier and is further metabolized to provide free choline for acetylcholine synthesis via choline acetyltransferase. Unlike choline bitartrate, the phospholipid structure of Alpha-GPC dramatically improves bioavailability and preferential delivery to neural tissue. It also directly increases neuronal membrane phospholipid content, supporting structural integrity. Several studies show it increases growth hormone release when taken pre-exercise.
Overview
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat. It is the most bioavailable oral choline source, efficiently crossing the blood-brain barrier to increase acetylcholine synthesis. Used clinically in Europe (Choline alfoscerate) for Alzheimer's disease and stroke. The preferred choline source when maximum ACh elevation is the goal.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
(2R)-2,3-dihydroxypropyl 2-(trimethylazaniumyl)ethyl phosphate
CAS Number
28319-77-9
Molecular Formula
C8H20NO6P
Molecular Mass
257.22 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
None known at standard doses. Pregnancy or breastfeeding (limited data). Acetylcholinesterase inhibitor interactions.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
No listings found for Alpha-GPC.
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
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9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
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View Full Dosage Guide →
Protocols, calculator & safety for Alpha-GPC
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4/1/2026Research Score
9 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Limited research available
Quick Facts
Molecular Weight
257.22 g/mol
CAS Number
28319-77-9
Trial Phase
Phase 4
Safety Profile
Low RiskCommon Side Effects
- • Headache (high doses)
- • Nausea
- • Insomnia if taken late
- • Heartburn
Stop Use If
- Bipolar disorder — ACh excess worsens mania
- Choline sensitivity
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Alpha-GPC used for in research?
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat. It is the most bioavailable oral choline source, efficiently crossing the blood-brain barrier to increase acetylcholine synthesis. Used clinically in Europe (Choline alfoscerate) for Alzheimer's disease and stroke. The preferred choline source when maximum ACh elevation is the goal.
What forms does Alpha-GPC come in?
Alpha-GPC is available in vials, capsules, and sprays forms.
How much does Alpha-GPC cost?
Pricing varies by vendor and form.
How do I compare Alpha-GPC vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
Research Tools
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
Nootropics
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
Nootropics
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.
Methylene Blue
Nootropics
Mitochondrial enhancer and cognitive support compound.