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CDP-Choline (Citicoline)
NootropicsPhase 4CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available. It provides both choline (for acetylcholine synthesis) and cytidine (which converts to uridine in the brain, supporting dopamine receptor expression).
Overview
Key Takeaways
- →Acetylcholine support
- →Dopamine D2 upregulation (via uridine)
- →Focus and attention
At A Glance
CDP-Choline provides choline for acetylcholine synthesis and simultaneously provides cytidine, which is converted to uridine in the brain. This dual delivery feeds both the cholinergic and dopaminergic systems. Uridine from CDP-Choline drives phosphatidylcholine synthesis for neuronal membrane maintenance and upregulates D2 receptor expression. CDP-Choline also directly increases dopamine levels in the striatum through mechanisms independent of its choline content. Clinical trials show it increases frontal lobe bioenergetics (ATP production) measured by phosphorus MRI spectroscopy.
CDP-Choline provides choline for acetylcholine synthesis and simultaneously provides cytidine, which is converted to uridine in the brain. This dual delivery feeds both the cholinergic and dopaminergic systems. Uridine from CDP-Choline drives phosphatidylcholine synthesis for neuronal membrane maintenance and upregulates D2 receptor expression. CDP-Choline also directly increases dopamine levels in the striatum through mechanisms independent of its choline content. Clinical trials show it increases frontal lobe bioenergetics (ATP production) measured by phosphorus MRI spectroscopy.
Overview
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available. It provides both choline (for acetylcholine synthesis) and cytidine (which converts to uridine in the brain, supporting dopamine receptor expression). FDA-recognized as a dietary supplement in the US; approved as a prescription drug in Europe and Japan for stroke and cognitive impairment.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl (3-trimethylaminopropyl) hydrogen phosphate
CAS Number
987-78-0
Molecular Formula
C14H26N4O11P2
Molecular Mass
488.32 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Known allergy to cytidine compounds. Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
No listings found for CDP-Choline (Citicoline).
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
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Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
Dihexa
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Lion's Mane Mushroom
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Methylene Blue
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Mitochondrial enhancer and cognitive support compound.
View Full Dosage Guide →
Protocols, calculator & safety for CDP-Choline (Citicoline)
Research Score
55 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Well-researched compound
Quick Facts
Molecular Weight
488.32 g/mol
CAS Number
987-78-0
Trial Phase
Phase 4
Safety Profile
Low RiskCommon Side Effects
- • Insomnia at high doses if taken late
- • Headache (paradoxically with choline excess)
- • Nausea
Stop Use If
- Choline sensitivity
- Bipolar mania — choline excess may worsen
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is CDP-Choline (Citicoline) used for in research?
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available. It provides both choline (for acetylcholine synthesis) and cytidine (which converts to uridine in the brain, supporting dopamine receptor expression). FDA-recognized as a dietary supplement in the US; approved as a prescription drug in Europe and Japan for stroke and cognitive impairment.
What forms does CDP-Choline (Citicoline) come in?
CDP-Choline (Citicoline) is available in vials, capsules, and sprays forms.
How much does CDP-Choline (Citicoline) cost?
Pricing varies by vendor and form.
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Research Tools
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
Dihexa
Nootropics
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
Nootropics
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.
Methylene Blue
Nootropics
Mitochondrial enhancer and cognitive support compound.