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Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair. Its primary active compounds — hericenones (fruiting body) and erinacines (mycelium) — are the only known natural compounds to stimulate NGF (nerve growth factor) synthesis in the brain.
Contains hericenones and erinacines that stimulate nerve growth factor (NGF) synthesis. NGF promotes neuronal growth, maintenance, and survival, supporting neuroplasticity, myelination, and cognitive function.
Contains hericenones and erinacines that stimulate nerve growth factor (NGF) synthesis. NGF promotes neuronal growth, maintenance, and survival, supporting neuroplasticity, myelination, and cognitive function.
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair. Its primary active compounds — hericenones (fruiting body) and erinacines (mycelium) — are the only known natural compounds to stimulate NGF (nerve growth factor) synthesis in the brain. A rare human clinical trial in mild cognitive impairment showed significant cognitive improvements at 3 grams daily over 16 weeks.
IUPAC Name
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Mushroom allergy. Bleeding disorders (may have antiplatelet effects). Pre-surgery (stop 2 weeks before). Pregnancy or breastfeeding.
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Protocols, calculator & safety for Lion's Mane Mushroom
537 PubMed studies
Data Completeness
75%Research Credibility
Well-researched compound
Molecular Weight
N/A
CAS Number
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Trial Phase
Phase 2
Common Side Effects
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Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair. Its primary active compounds — hericenones (fruiting body) and erinacines (mycelium) — are the only known natural compounds to stimulate NGF (nerve growth factor) synthesis in the brain. A rare human clinical trial in mild cognitive impairment showed significant cognitive improvements at 3 grams daily over 16 weeks.
Lion's Mane Mushroom is available in vials, capsules, and sprays forms.
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Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Nootropics
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Nootropics
Mitochondrial enhancer and cognitive support compound.