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Noopept
NootropicsRussia ApprovedNoopept (GVS-111) is a synthetic dipeptide nootropic developed in Russia and approved there as a cognitive enhancer. Structurally related to the racetam family, it is 1000x more potent than piracetam by weight.
Overview
Key Takeaways
- →Memory enhancement
- →BDNF/NGF upregulation
- →Neuroprotection
At A Glance
Noopept is metabolized to cycloprolylglycine (CPG) — an endogenous neuropeptide — and also acts directly on AMPA receptors as a positive allosteric modulator, enhancing glutamatergic neurotransmission critical for learning and memory. It significantly upregulates BDNF and NGF expression in the hippocampus and cortex, driving neurogenesis and synaptic plasticity. It modulates inhibitory alpha oscillations in the brain, improving signal-to-noise in cognitive processing. Neuroprotective properties include reducing glutamate-induced excitotoxicity and inhibiting amyloid beta aggregation in vitro.
Noopept is metabolized to cycloprolylglycine (CPG) — an endogenous neuropeptide — and also acts directly on AMPA receptors as a positive allosteric modulator, enhancing glutamatergic neurotransmission critical for learning and memory. It significantly upregulates BDNF and NGF expression in the hippocampus and cortex, driving neurogenesis and synaptic plasticity. It modulates inhibitory alpha oscillations in the brain, improving signal-to-noise in cognitive processing. Neuroprotective properties include reducing glutamate-induced excitotoxicity and inhibiting amyloid beta aggregation in vitro.
Overview
Noopept (GVS-111) is a synthetic dipeptide nootropic developed in Russia and approved there as a cognitive enhancer. Structurally related to the racetam family, it is 1000x more potent than piracetam by weight. Research focuses on its potent BDNF and NGF upregulation, neuroprotective effects, and cognitive enhancement through AMPA receptor potentiation. One of the most popular and well-studied synthetic nootropics globally.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
N-phenylacetyl-L-prolylglycine ethyl ester
CAS Number
157115-85-0
Molecular Formula
C17H22N2O4
Molecular Mass
318.37 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Known hypersensitivity. Use caution with anticoagulants. Pregnancy or breastfeeding. History of seizures (limited data).
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
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Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
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Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
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CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
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Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
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4/1/2026Research Score
106 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Well-researched compound
Quick Facts
Molecular Weight
318.37 g/mol
CAS Number
157115-85-0
Trial Phase
Russia Approved
Safety Profile
Low RiskCommon Side Effects
- • Brain fog at high doses
- • Headache (without choline)
- • Irritability
- • Sleep disruption if dosed late
Stop Use If
- Hypersensitivity
- Pregnancy/breastfeeding (insufficient data)
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Noopept used for in research?
Noopept (GVS-111) is a synthetic dipeptide nootropic developed in Russia and approved there as a cognitive enhancer. Structurally related to the racetam family, it is 1000x more potent than piracetam by weight. Research focuses on its potent BDNF and NGF upregulation, neuroprotective effects, and cognitive enhancement through AMPA receptor potentiation. One of the most popular and well-studied synthetic nootropics globally.
What forms does Noopept come in?
Noopept is available in vials, capsules, and sprays forms.
How much does Noopept cost?
Pricing varies by vendor and form.
How do I compare Noopept vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
Research Tools
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
Nootropics
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
Nootropics
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.