Research Use Only
This site is an independent educational resource for research compounds. We do not sell, distribute, or endorse human consumption of any compound. By entering, you confirm you are 21 years of age or older and agree to our Terms & Privacy Policy.
MK-677 (Ibutamoren)
Growth Hormone / IGF-1 AxisPhase 2Also known as: Ibutamoren
MK-677 (Ibutamoren) is an orally active non-peptide growth hormone secretagogue that mimics ghrelin's action at the GHS-R1a receptor. Despite being called a peptide by the community, it's technically a small molecule.
Overview
Key Takeaways
- →Oral bioavailability
- →IGF-1 elevation
- →Sleep quality
- →Half-life: 4–6 hours (effects on GH last ~24 hours due to IGF-1 elevation)
At A Glance
MK-677 acts as a potent ghrelin mimetic at the growth hormone secretagogue receptor 1a. Oral bioavailability of ~60% enables once-daily dosing, producing sustained elevations of GH and IGF-1 levels. Unlike injectable GHRH/GHRP combos, MK-677 raises baseline GH levels rather than producing discrete pulses, leading to higher average IGF-1 over 24 hours. It also promotes slow-wave sleep through hypothalamic mechanisms, with clinical trials confirming improved sleep architecture.
MK-677 acts as a potent ghrelin mimetic at the growth hormone secretagogue receptor 1a. Oral bioavailability of ~60% enables once-daily dosing, producing sustained elevations of GH and IGF-1 levels. Unlike injectable GHRH/GHRP combos, MK-677 raises baseline GH levels rather than producing discrete pulses, leading to higher average IGF-1 over 24 hours. It also promotes slow-wave sleep through hypothalamic mechanisms, with clinical trials confirming improved sleep architecture.
Overview
MK-677 (Ibutamoren) is an orally active non-peptide growth hormone secretagogue that mimics ghrelin's action at the GHS-R1a receptor. Despite being called a peptide by the community, it's technically a small molecule. Extensive clinical data exists from Merck's Phase 2 trials showing significant GH and IGF-1 elevation with daily oral dosing. Research covers body composition, bone density, sleep, and cognition.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
2-amino-2-methyl-N-[1-(methylsulfonylmethyl)-2-(1-methylpropyl)-3-(1H-indol-3-ylmethyl)...] (complex structure)
CAS Number
159634-47-6
Molecular Formula
C27H36N4O5S
Molecular Mass
528.67 g/mol
Dosing & Protocols
Unlock Dosing Protocols
Create a free account to:
- View beginner, intermediate & advanced protocols
- See weight-based dosing calculations
- Access cycle length & frequency data
Join 2,800+ researchers
Research
Unlock Research Data
Create a free account to:
- Browse PubMed study summaries
- See clinical trial phases & results
- Access mechanism of action details
Join 2,800+ researchers
Interactions
Interaction Matrix
Contraindications
Active cancer or history of cancer. Diabetes or pre-diabetes (worsens insulin resistance). History of pituitary tumors. Intracranial hypertension. Pregnancy or breastfeeding. Children with open growth plates (unless under medical supervision).
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$49.99
$0.0667
1
1
liquid
Vendors Selling MK-677 (Ibutamoren)
Related Compounds
View AllCJC-1295 (Mod GRF 1-29)
Growth Hormone / IGF-1 Axis
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.
CJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
Hexarelin
Growth Hormone / IGF-1 Axis
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.
View Full Dosage Guide →
Protocols, calculator & safety for MK-677 (Ibutamoren)
Research Score
45 PubMed studies
Quality Indicators
Data Completeness
100%Research Credibility
Quick Facts
Half-Life
4–6 hours (effects on GH last ~24 hours due to IGF-1 elevation)
Molecular Weight
528.67 g/mol
Administration
Oral
CAS Number
159634-47-6
Trial Phase
Phase 2
Safety Profile
Moderate RiskCommon Side Effects
- • Increased appetite
- • Water retention
- • Lethargy
- • Elevated fasting glucose
- • Increased cortisol
Stop Use If
- Active cancer
- Uncontrolled diabetes or insulin resistance
- Active edema
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is MK-677 (Ibutamoren) used for in research?
MK-677 (Ibutamoren) is an orally active non-peptide growth hormone secretagogue that mimics ghrelin's action at the GHS-R1a receptor. Despite being called a peptide by the community, it's technically a small molecule. Extensive clinical data exists from Merck's Phase 2 trials showing significant GH and IGF-1 elevation with daily oral dosing. Research covers body composition, bone density, sleep, and cognition.
What forms does MK-677 (Ibutamoren) come in?
MK-677 (Ibutamoren) is available in liquid form.
How much does MK-677 (Ibutamoren) cost?
Prices start at $49.99 across 1 verified vendor.
How do I compare MK-677 (Ibutamoren) vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View AllCJC-1295 (Mod GRF 1-29)
Growth Hormone / IGF-1 Axis
CJC-1295 without DAC (Modified GRF 1-29) is a synthetic 29-amino acid GHRH analog with four amino acid substitutions that extend its half-life from under 2 minutes to approximately 30 minutes.
CJC-1295 with DAC
Growth Hormone / IGF-1 Axis
CJC-1295 with DAC uses a Drug Affinity Complex linker (maleimidopropionic acid) that forms a permanent covalent bond with serum albumin after injection, extending the half-life to 6–8 days.
GHRP-2
Growth Hormone / IGF-1 Axis
GHRP-2 is a synthetic hexapeptide growth hormone-releasing peptide that potently stimulates GH release from the pituitary gland.
GHRP-6
Growth Hormone / IGF-1 Axis
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue and one of the original GHRPs studied.
Hexarelin
Growth Hormone / IGF-1 Axis
Hexarelin is a synthetic hexapeptide growth hormone secretagogue that produces the most potent GH release of any GHRP.
IGF-1 LR3
Growth Hormone / IGF-1 Axis
IGF-1 LR3 (Long R3 IGF-1) is a modified analog of insulin-like growth factor 1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension.