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    Ion Peptide logo

    Best price right now

    $7.90/mg· $79.00 for 10mg at Ion Peptide

    VIP

    NootropicPreclinical

    Also known as: Vasoactive Intestinal Peptide, Vasoactive Intestinal Polypeptide, PHM-27 precursor neuropeptide

    VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide and hormone that is widely expressed throughout the central and peripheral nervous systems, gastrointestinal tract, and immune system. It is a member of the glucagon superfamily.

    Half-Life: ~2 minutes (IV); ~60–90 minutes (subcutaneous)Route: Subcutaneous, Intranasal, Intravenous
    Last reviewed:
    Nootropic
    Category
    Preclinical
    Research Stage

    Overview

    Best Price Available

    Ion Peptide logo

    Ion Peptide

    $79.00

    1 vial · vial

    At A Glance

    Mechanism

    VIP acts on VPAC1 and VPAC2 receptors (G-protein coupled, Gs-linked), stimulating adenylyl cyclase and elevating cAMP in target cells. Central effects include modulation of the suprachiasmatic nucleus (SCN) — VIP is a key SCN neuropeptide regulating circadian rhythm synchronizati

    Half-Life
    ~2 minutes (IV); ~60–90 minutes (subcutaneous)
    Dosing
    once or twice daily
    Dose Range
    50mcg
    Routes
    SubcutaneousIntranasalIntravenous
    Common Vials
    10mg
    Potential Benefits
    Potent anti-inflammatory signaling — inhibits TNF-α, IL-6, IL-12 via cAMP pathwayCircadian rhythm regulation through suprachiasmatic nucleus (SCN) VPAC receptor activationBronchodilation — potential research application in airway inflammation modelsVasodilation and blood flow regulation in peripheral vascular researchNeuroprotection — VPAC2 agonism supports neuronal survival in excitotoxicity modelsCIRS/mast cell activation research — increasingly studied in chronic inflammatory syndromesGut motility modulation and GI mucosal protection
    Safety Notes
    Common
    Facial flushingHypotension (vasodilatory effect)NauseaTachycardia at higher doses
    Serious
    Significant hypotension risk at IV doses — not for unsupervised IV useBronchospasm paradox (rare)No long-term human safety data for subcutaneous research use

    Overview

    VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide and hormone that is widely expressed throughout the central and peripheral nervous systems, gastrointestinal tract, and immune system. It is a member of the glucagon superfamily. VIP functions as a potent vasodilator and bronchodilator, as a neuromodulator in the brain (circadian rhythm, neuroprotection), as an immunomodulator with predominantly anti-inflammatory actions, and as a GI motility regulator. VIP has attracted research interest for CIRS (Chronic Inflammatory Response Syndrome), mast cell activation, small fiber neuropathy, and autonomic nervous system regulation. It is one of the few neuropeptides with simultaneous central, peripheral, and immune functions.

    Chemical Information

    IUPAC Name

    Not yet available

    CAS Number

    Not yet available

    Molecular Formula

    Not yet available

    Molecular Mass

    Not yet available

    Chemical data is being compiled for this compound.

    Dosing & Protocols

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    Research

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    Interactions

    Interaction and contraindication data is being compiled for VIP. Check back soon.

    General Safety Note

    Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.

    Best Price

    $79.00

    Best $/mg

    $7.9000

    Vendors

    1

    Listings

    1

    vial

    Form
    Sort
    Vendor Product Form Qty Price $/mg Coupon
    Ion Peptide logo
    Ion Peptide
    70
    🇺🇸US🌍International
    VIP 10mg vial 1 vial● In Stock $79.00BEST $7.900

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    Current low
    $79.00
    as of Apr 22, 2026
    7-day low
    no 7d data yet
    30-day low
    no 30d data yet
    30-day change
    baseline building

    Tracking since Apr 22, 2026 · 1 data point

    Vendors Selling VIP

    How we score these vendors

    Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.

    View Scorecard

    Related Compounds

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    Alpha-GPC

    NootropicPhase 4

    Alpha-GPC (chemical name L-alpha-glycerylphosphorylcholine; pharmaceutical name choline alfoscerate) is a naturally occurring cholinergic compound that serves as a highly bioavailable precursor to both acetylcholine (the primary neurotransmitter of the cholinergic system, central to learning, memory, attention, and neuromuscular function) and phosphatidylcholine (the principal phospholipid building block of neuronal cell membranes).

    9 studiesView Profile

    Caffeine

    NootropicPreclinical

    Caffeine (1,3,7-trimethylxanthine) is a natural methylxanthine alkaloid found in the seeds, fruits, leaves, and bark of over 60 plant species — most notably Coffea (coffee), Camellia sinensis (tea), Theobroma cacao (cacao), Paullinia cupana (guaraná), Ilex paraguariensis (yerba mate), and Cola acuminata (kola nut).

    47499 studiesView Profile

    CDP-Choline

    NootropicPhase 4

    CDP-choline (cytidine 5'-diphosphocholine, pharmaceutical name citicoline) is a naturally occurring intracellular intermediate in the Kennedy pathway for phosphatidylcholine synthesis — the primary biochemical route by which all nucleated cells produce the dominant membrane phospholipid.

    56 studiesView Profile

    Inositol

    NootropicPreclinical

    Inositol is a naturally-occurring cyclic sugar alcohol (cyclohexanehexol) that functions as a critical structural component of cell membranes and a second-messenger precursor in intracellular signaling.

    53071 studiesView Profile

    L-Tryptophan

    NootropicPreclinical

    L-Tryptophan is one of the nine essential amino acids — meaning the human body cannot synthesize it and must obtain it from dietary protein — and is the direct metabolic precursor to serotonin, melatonin, and (via a separate route) the vitamin niacin (nicotinamide / NAD+).

    80432 studiesView Profile

    Magnesium L-Threonate

    NootropicPreclinical

    Magnesium L-Threonate is a proprietary chelated form of magnesium in which the magnesium cation is bound to L-threonic acid — a metabolite of ascorbic acid (vitamin C) — forming the salt commonly marketed under the brand name Magtein.

    207 studiesView Profile

    View Full Dosage Guide →

    Protocols, calculator & safety for VIP

    Best Price

    Ion Peptide logo

    Ion Peptide

    $79.00

    1 vendors · 1 listings

    Research Score

    45

    0 PubMed studies

    Quality Indicators

    Data Completeness

    63%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Studies
    Interactions
    Vendor Listings

    Quick Facts

    Half-Life

    ~2 minutes (IV); ~60–90 minutes (subcutaneous)

    Administration

    Subcutaneous, Intranasal, Intravenous

    Trial Phase

    Preclinical

    Safety Profile

    Common Side Effects

    • Facial flushing
    • Hypotension (vasodilatory effect)
    • Nausea
    • Tachycardia at higher doses

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is VIP used for in research?

    VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide and hormone that is widely expressed throughout the central and peripheral nervous systems, gastrointestinal tract, and immune system. It is a member of the glucagon superfamily. VIP functions as a potent vasodilator and bronchodilator, as a neuromodulator in the brain (circadian rhythm, neuroprotection), as an immunomodulator with predominantly anti-inflammatory actions, and as a GI motility regulator. VIP has attracted research interest for CIRS (Chronic Inflammatory Response Syndrome), mast cell activation, small fiber neuropathy, and autonomic nervous system regulation. It is one of the few neuropeptides with simultaneous central, peripheral, and immune functions.

    What forms does VIP come in?

    VIP is available in vial form.

    How much does VIP cost?

    Prices start at $79.00 across 1 verified vendor.

    How do I compare VIP vendors?

    Compare prices, payment methods, shipping, and COA scores across 1 vendor.

    Research Tools

    Related Compounds

    View All

    Alpha-GPC

    NootropicPhase 4

    Alpha-GPC (chemical name L-alpha-glycerylphosphorylcholine; pharmaceutical name choline alfoscerate) is a naturally occurring cholinergic compound that serves as a highly bioavailable precursor to both acetylcholine (the primary neurotransmitter of the cholinergic system, central to learning, memory, attention, and neuromuscular function) and phosphatidylcholine (the principal phospholipid building block of neuronal cell membranes).

    9 studiesView Profile

    Caffeine

    NootropicPreclinical

    Caffeine (1,3,7-trimethylxanthine) is a natural methylxanthine alkaloid found in the seeds, fruits, leaves, and bark of over 60 plant species — most notably Coffea (coffee), Camellia sinensis (tea), Theobroma cacao (cacao), Paullinia cupana (guaraná), Ilex paraguariensis (yerba mate), and Cola acuminata (kola nut).

    47499 studiesView Profile

    CDP-Choline

    NootropicPhase 4

    CDP-choline (cytidine 5'-diphosphocholine, pharmaceutical name citicoline) is a naturally occurring intracellular intermediate in the Kennedy pathway for phosphatidylcholine synthesis — the primary biochemical route by which all nucleated cells produce the dominant membrane phospholipid.

    56 studiesView Profile

    Inositol

    NootropicPreclinical

    Inositol is a naturally-occurring cyclic sugar alcohol (cyclohexanehexol) that functions as a critical structural component of cell membranes and a second-messenger precursor in intracellular signaling.

    53071 studiesView Profile

    L-Tryptophan

    NootropicPreclinical

    L-Tryptophan is one of the nine essential amino acids — meaning the human body cannot synthesize it and must obtain it from dietary protein — and is the direct metabolic precursor to serotonin, melatonin, and (via a separate route) the vitamin niacin (nicotinamide / NAD+).

    80432 studiesView Profile

    Magnesium L-Threonate

    NootropicPreclinical

    Magnesium L-Threonate is a proprietary chelated form of magnesium in which the magnesium cation is bound to L-threonic acid — a metabolite of ascorbic acid (vitamin C) — forming the salt commonly marketed under the brand name Magtein.

    207 studiesView Profile

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