VIP
NootropicPreclinicalAlso known as: Vasoactive Intestinal Peptide, Vasoactive Intestinal Polypeptide, PHM-27 precursor neuropeptide
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide and hormone that is widely expressed throughout the central and peripheral nervous systems, gastrointestinal tract, and immune system. It is a member of the glucagon superfamily.
Overview
At A Glance
VIP acts on VPAC1 and VPAC2 receptors (G-protein coupled, Gs-linked), stimulating adenylyl cyclase and elevating cAMP in target cells. Central effects include modulation of the suprachiasmatic nucleus (SCN) — VIP is a key SCN neuropeptide regulating circadian rhythm synchronizati…
Overview
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide and hormone that is widely expressed throughout the central and peripheral nervous systems, gastrointestinal tract, and immune system. It is a member of the glucagon superfamily. VIP functions as a potent vasodilator and bronchodilator, as a neuromodulator in the brain (circadian rhythm, neuroprotection), as an immunomodulator with predominantly anti-inflammatory actions, and as a GI motility regulator. VIP has attracted research interest for CIRS (Chronic Inflammatory Response Syndrome), mast cell activation, small fiber neuropathy, and autonomic nervous system regulation. It is one of the few neuropeptides with simultaneous central, peripheral, and immune functions.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
Not yet available
Chemical data is being compiled for this compound.
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for VIP. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
$79.00
$7.9000
1
1
vial
Tracking since Apr 22, 2026 · 1 data point
Vendors Selling VIP
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Related Compounds
View AllAlpha-GPC
NootropicPhase 4Alpha-GPC (chemical name L-alpha-glycerylphosphorylcholine; pharmaceutical name choline alfoscerate) is a naturally occurring cholinergic compound that serves as a highly bioavailable precursor to both acetylcholine (the primary neurotransmitter of the cholinergic system, central to learning, memory, attention, and neuromuscular function) and phosphatidylcholine (the principal phospholipid building block of neuronal cell membranes).
Caffeine
NootropicPreclinicalCaffeine (1,3,7-trimethylxanthine) is a natural methylxanthine alkaloid found in the seeds, fruits, leaves, and bark of over 60 plant species — most notably Coffea (coffee), Camellia sinensis (tea), Theobroma cacao (cacao), Paullinia cupana (guaraná), Ilex paraguariensis (yerba mate), and Cola acuminata (kola nut).
CDP-Choline
NootropicPhase 4CDP-choline (cytidine 5'-diphosphocholine, pharmaceutical name citicoline) is a naturally occurring intracellular intermediate in the Kennedy pathway for phosphatidylcholine synthesis — the primary biochemical route by which all nucleated cells produce the dominant membrane phospholipid.
Inositol
NootropicPreclinicalInositol is a naturally-occurring cyclic sugar alcohol (cyclohexanehexol) that functions as a critical structural component of cell membranes and a second-messenger precursor in intracellular signaling.
L-Tryptophan
NootropicPreclinicalL-Tryptophan is one of the nine essential amino acids — meaning the human body cannot synthesize it and must obtain it from dietary protein — and is the direct metabolic precursor to serotonin, melatonin, and (via a separate route) the vitamin niacin (nicotinamide / NAD+).
Magnesium L-Threonate
NootropicPreclinicalMagnesium L-Threonate is a proprietary chelated form of magnesium in which the magnesium cation is bound to L-threonic acid — a metabolite of ascorbic acid (vitamin C) — forming the salt commonly marketed under the brand name Magtein.
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Protocols, calculator & safety for VIP
Research Score
0 PubMed studies
Quality Indicators
Data Completeness
63%Quick Facts
Half-Life
~2 minutes (IV); ~60–90 minutes (subcutaneous)
Administration
Subcutaneous, Intranasal, Intravenous
Trial Phase
Preclinical
Safety Profile
Common Side Effects
- • Facial flushing
- • Hypotension (vasodilatory effect)
- • Nausea
- • Tachycardia at higher doses
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is VIP used for in research?
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide and hormone that is widely expressed throughout the central and peripheral nervous systems, gastrointestinal tract, and immune system. It is a member of the glucagon superfamily. VIP functions as a potent vasodilator and bronchodilator, as a neuromodulator in the brain (circadian rhythm, neuroprotection), as an immunomodulator with predominantly anti-inflammatory actions, and as a GI motility regulator. VIP has attracted research interest for CIRS (Chronic Inflammatory Response Syndrome), mast cell activation, small fiber neuropathy, and autonomic nervous system regulation. It is one of the few neuropeptides with simultaneous central, peripheral, and immune functions.
What forms does VIP come in?
VIP is available in vial form.
How much does VIP cost?
Prices start at $79.00 across 1 verified vendor.
How do I compare VIP vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View AllAlpha-GPC
NootropicPhase 4Alpha-GPC (chemical name L-alpha-glycerylphosphorylcholine; pharmaceutical name choline alfoscerate) is a naturally occurring cholinergic compound that serves as a highly bioavailable precursor to both acetylcholine (the primary neurotransmitter of the cholinergic system, central to learning, memory, attention, and neuromuscular function) and phosphatidylcholine (the principal phospholipid building block of neuronal cell membranes).
Caffeine
NootropicPreclinicalCaffeine (1,3,7-trimethylxanthine) is a natural methylxanthine alkaloid found in the seeds, fruits, leaves, and bark of over 60 plant species — most notably Coffea (coffee), Camellia sinensis (tea), Theobroma cacao (cacao), Paullinia cupana (guaraná), Ilex paraguariensis (yerba mate), and Cola acuminata (kola nut).
CDP-Choline
NootropicPhase 4CDP-choline (cytidine 5'-diphosphocholine, pharmaceutical name citicoline) is a naturally occurring intracellular intermediate in the Kennedy pathway for phosphatidylcholine synthesis — the primary biochemical route by which all nucleated cells produce the dominant membrane phospholipid.
Inositol
NootropicPreclinicalInositol is a naturally-occurring cyclic sugar alcohol (cyclohexanehexol) that functions as a critical structural component of cell membranes and a second-messenger precursor in intracellular signaling.
L-Tryptophan
NootropicPreclinicalL-Tryptophan is one of the nine essential amino acids — meaning the human body cannot synthesize it and must obtain it from dietary protein — and is the direct metabolic precursor to serotonin, melatonin, and (via a separate route) the vitamin niacin (nicotinamide / NAD+).
Magnesium L-Threonate
NootropicPreclinicalMagnesium L-Threonate is a proprietary chelated form of magnesium in which the magnesium cation is bound to L-threonic acid — a metabolite of ascorbic acid (vitamin C) — forming the salt commonly marketed under the brand name Magtein.
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