CJC-1295 with DAC vs CJC-1295 (Mod GRF 1-29)
Independent, side-by-side comparison of CJC-1295 with DAC and CJC-1295 (Mod GRF 1-29): mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.
Live price snapshot
CJC-1295 with DAC
CJC-1295 (Mod GRF 1-29)
CJC-1295 with DAC
CJC-1295 with DAC (Drug Affinity Complex) is a modified form of CJC-1295 that incorporates a maleimidopropionic acid (MPA) reactive group at the C-terminus. Once injected, this MPA group forms a covalent thioether bond…
Live lowest price: $34.99 across 5 vendors
Full CJC-1295 with DAC profileCJC-1295 (Mod GRF 1-29)
CJC-1295 without DAC (also called Modified GRF 1-29 or MOD-GRF 1-29) is a 30-amino-acid analog of the first 29 residues of endogenous Growth Hormone Releasing Hormone (GHRH), with four strategic substitutions (D-Ala² for…
Live lowest price: $29.00 across 6 vendors
Full CJC-1295 (Mod GRF 1-29) profileSide-by-side comparison
| Attribute | CJC-1295 with DAC | CJC-1295 (Mod GRF 1-29) |
|---|---|---|
| Category | Growth Hormone / IGF-1 Axis | Growth Hormone / IGF-1 Axis |
| Research Stage | Phase II | Phase 2 (clinical development discontinued) |
| Mechanism of Action | CJC-1295 with DAC has the same pharmacodynamic mechanism as the non-DAC variant (GHRH receptor agonism on pituitary somatotrophs) but radically different pharmacokinetics. 1. Albumin conjugation — the central pharmacokinetic feature - The MPA… | MOD-GRF 1-29 exerts its effect through a single, well-characterized receptor: the GHRH receptor (GHRHR) on anterior-pituitary somatotroph cells. The signaling cascade is the same as endogenous GHRH; the difference is pharmacokinetics. 1. GHRH receptor agonism… |
| Half-Life | 6–8 days (due to albumin binding via DAC) | ~30 minutes (without DAC / MOD-GRF 1-29); 8+ days (with DAC, due to covalent albumin binding) |
| Typical Dose Range | 1,000–2,000 mcg (1–2 mg) per injection | Without DAC: 100-300 mcg subcutaneous 1-3x daily (typically pre-bedtime); With DAC: 1000-2000 mcg subcutaneous once weekly |
| Dosing Frequency | Once per week | 1–3 times daily, typically before bed and/or upon waking |
| Administration | Subcutaneous | Subcutaneous |
| Side Effects | Expected / benign - Injection-site reaction — redness, slight swelling, itching at the weekly injection - Facial flushing / warmth post-injection, sometimes lasting hours (longer than with MOD-GRF 1-29) - Vivid dreams — very common in first weeks - Mild nausea… | Expected / benign - Injection-site reaction — mild redness, itching, small bump; 24-48 hour resolution - Facial flushing / warmth 15-30 min post-injection (histamine release from GHRH action); typically diminishes after week 1-2 - Mild nausea in first week at… |
| Molecular Weight | ~3647 Da | 3367.9 Da |
| Common Vial Sizes | 2mg, 5mg | 2mg, 5mg |
Price History
3 data points- BM
- VANDL Labs
- Ion Peptide
Price History
2 data points- VANDL Labs
- Ion Peptide
CJC-1295 with DAC — potential benefits
- Sustained IGF-1 elevation (1.5-3x baseline) for 28+ days
- Convenient weekly subcutaneous dosing
- Improved body composition (lean mass, fat loss)
- Enhanced recovery from training and injury
- Albumin conjugation extends half-life to ~8 days
- Stimulates endogenous GH production vs exogenous replacement
- Dose-dependent GH elevation 2-10x baseline
- Phase 1 clinical data in 50 healthy adults (Teichman 2006)
CJC-1295 (Mod GRF 1-29) — potential benefits
- Preserves physiologic pulsatile GH secretion
- Stimulates endogenous GH release (2-5x baseline per pulse)
- 3-5x greater GH response when stacked with ipamorelin
- Modest IGF-1 elevation (1.5-2x baseline)
- Improved sleep depth and architecture
- Enhanced recovery from exercise and injury
- Body composition improvements (lean mass preservation, modest fat loss)
- Lower desensitization risk vs CJC-1295 with DAC
Frequently asked
What's the difference between CJC-1295 with DAC and CJC-1295 (Mod GRF 1-29)?
CJC-1295 with DAC is a growth hormone / igf-1 axis that cjc-1295 with dac has the same pharmacodynamic mechanism as the non-dac variant (ghrh receptor agonism on pituitary somatotrophs) but radically different pharmacokinetics. 1.…. CJC-1295 (Mod GRF 1-29) is a growth hormone / igf-1 axis that mod-grf 1-29 exerts its effect through a single, well-characterized receptor: the ghrh receptor (ghrhr) on anterior-pituitary somatotroph cells. the signaling cascade is the same…. The two differ in mechanism, half-life (6–8 days (due to albumin binding via DAC) vs ~30 minutes (without DAC / MOD-GRF 1-29); 8+ days (with DAC, due to covalent albumin binding)), and typical dose range.
Which has the longer half-life, CJC-1295 with DAC or CJC-1295 (Mod GRF 1-29)?
CJC-1295 with DAC has a half-life of 6–8 days (due to albumin binding via DAC). CJC-1295 (Mod GRF 1-29) has a half-life of ~30 minutes (without DAC / MOD-GRF 1-29); 8+ days (with DAC, due to covalent albumin binding). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, CJC-1295 with DAC or CJC-1295 (Mod GRF 1-29)?
Current lowest live price on BodyHackGuide: CJC-1295 with DAC from $34.99, CJC-1295 (Mod GRF 1-29) from $29.00. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers.
Can you stack CJC-1295 with DAC and CJC-1295 (Mod GRF 1-29)?
Stacking depends on mechanism overlap, safety profile, and goals. CJC-1295 with DAC and CJC-1295 (Mod GRF 1-29) should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is an independent research reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks — this never affects the data or pricing shown. See editorial standards and affiliate disclosure.
