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Thymosin Alpha-1 (TA1)
Immune & InflammationFDA ApprovedAlso known as: Ta1
Thymosin Alpha-1 is a 28-amino acid peptide derived from the thymosin fraction 5 of thymic tissue. FDA-approved as Zadaxin in numerous countries (not the US) for hepatitis B, hepatitis C, and immune deficiency states.
Overview
Key Takeaways
- →Immune enhancement
- →Antiviral defense
- →Cancer adjuvant therapy
- →Half-life: ~2 hours
At A Glance
TA1 activates TLR2 and TLR9 signaling on dendritic cells and macrophages, triggering innate immune responses and T-helper cell maturation. It promotes differentiation of naïve T-cells into Th1 and regulatory T-cells while suppressing Th2-dominated allergic responses. IL-2, IL-7, and interferon-alpha production are significantly upregulated. In cancer research, TA1 enhances tumor antigen presentation and natural killer cell cytotoxicity.
TA1 activates TLR2 and TLR9 signaling on dendritic cells and macrophages, triggering innate immune responses and T-helper cell maturation. It promotes differentiation of naïve T-cells into Th1 and regulatory T-cells while suppressing Th2-dominated allergic responses. IL-2, IL-7, and interferon-alpha production are significantly upregulated. In cancer research, TA1 enhances tumor antigen presentation and natural killer cell cytotoxicity.
Overview
Thymosin Alpha-1 is a 28-amino acid peptide derived from the thymosin fraction 5 of thymic tissue. FDA-approved as Zadaxin in numerous countries (not the US) for hepatitis B, hepatitis C, and immune deficiency states. Extensively researched for its immunomodulatory effects, anti-tumor properties, and potential in COVID-19 treatment. One of the most clinically validated peptides available.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
L-seryl-L-alpha-aspartylL-alanyl-L-alanyl-L-valyl-L-alpha-aspartyl-L-threonyl... (28 aa sequence)
CAS Number
62304-98-7
Molecular Formula
C129H215N33O55
Molecular Mass
3108.3 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Active autoimmune conditions being treated with immunosuppressants. Organ transplant recipients. Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
Research Score
699 PubMed studies
Quality Indicators
Data Completeness
100%COA Verification
10
Verified COAs
2
Vendors w/ COA
High verification rate (83%)
Latest test: 3/1/2026
Research Credibility
Well-researched compound
Quick Facts
Half-Life
~2 hours
Molecular Weight
3108.3 g/mol
Administration
Subcutaneous
CAS Number
62304-98-7
Trial Phase
FDA Approved
Safety Profile
Low RiskCommon Side Effects
- • Mild injection site reactions
- • Transient fatigue
- • Flu-like symptoms (early doses)
Stop Use If
- Active autoimmune disease (consult physician)
- Organ transplant recipients on immunosuppression
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Thymosin Alpha-1 (TA1) used for in research?
Thymosin Alpha-1 is a 28-amino acid peptide derived from the thymosin fraction 5 of thymic tissue. FDA-approved as Zadaxin in numerous countries (not the US) for hepatitis B, hepatitis C, and immune deficiency states. Extensively researched for its immunomodulatory effects, anti-tumor properties, and potential in COVID-19 treatment. One of the most clinically validated peptides available.
What forms does Thymosin Alpha-1 (TA1) come in?
Thymosin Alpha-1 (TA1) is available in vial form.
How much does Thymosin Alpha-1 (TA1) cost?
Prices start at $44.99 across 2 verified vendors.
How do I compare Thymosin Alpha-1 (TA1) vendors?
Compare prices, payment methods, shipping, and COA scores across 2 vendors.