TB-500 (Thymosin Beta-4) vs Thymosin Alpha-1 (TA1)
Independent, side-by-side comparison of TB-500 (Thymosin Beta-4) and Thymosin Alpha-1 (TA1): mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.
Live price snapshot
TB-500 (Thymosin Beta-4)
Thymosin Alpha-1 (TA1)
TB-500 (Thymosin Beta-4)
TB-500 is a synthetic peptide fragment of thymosin beta-4 (Tbeta4), a 43-amino-acid protein that is one of the most abundant intracellular actin-sequestering molecules in mammalian cells. With a molecular weight of…
Live lowest price: $29.00 across 9 vendors
Full TB-500 (Thymosin Beta-4) profileThymosin Alpha-1 (TA1)
Thymosin alpha-1 (Tα1) is a 28-amino-acid N-acetylated peptide (N-Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn) isolated and characterized by Allan…
Live lowest price: $39.99 across 3 vendors
Full Thymosin Alpha-1 (TA1) profileSide-by-side comparison
| Attribute | TB-500 (Thymosin Beta-4) | Thymosin Alpha-1 (TA1) |
|---|---|---|
| Category | Injury, Repair & Recovery | Immune & Inflammation |
| Research Stage | Phase 2/3 (topical ophthalmic, RGN-259); preclinical/research-use-only for systemic injectable use | Approved (International) |
| Mechanism of Action | Actin Sequestration and Cytoskeletal Dynamics The primary molecular function of thymosin beta-4 (and the synthetic peptide sold as TB-500) is binding to monomeric G-actin in a 1:1 complex, preventing its polymerization into F-actin filaments (PMID: 1627561).… | Thymosin alpha-1 does not act through a single canonical receptor in the way many peptides do. Its mechanism is pleiotropic, involving pattern-recognition receptors, modulation of immune cell maturation and function, and shifts in cytokine signaling patterns.… |
| Half-Life | Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure. | ~2 hours |
| Typical Dose Range | 2000-5000 mcg (2-5 mg) subcutaneous 2x weekly loading; 2000 mcg (2 mg) weekly maintenance | 1,600 mcg (1.6 mg) per injection (standard clinical dose) |
| Dosing Frequency | 2x per week during loading; 1x per week maintenance | Twice weekly (subcutaneous) - the approved Zadaxin schedule; alternatively 900 mcg daily for intensive short-term courses |
| Administration | Subcutaneous, Intramuscular | Subcutaneous |
| Side Effects | Generally well-tolerated. Occasional mild headache, nausea, or lethargy. Localized irritation at injection site. Rare: flu-like symptoms, temporary fatigue during initial use. | Tα1 has one of the most benign side-effect profiles in the peptide space, supported by 45+ years of clinical experience in approved indications. Most users experience no acute side effects beyond mild injection site discomfort. Common (5-15% of users): -… |
| Molecular Weight | Full-length thymosin beta-4 (the form sold as TB-500): ~4963 Da (N-terminally acetylated) / ~4921 Da for the free peptide, 43 amino acids. The short LKKTETQ actin-binding fragment is a 7-amino-acid heptapeptide (~847 Da). | 3108 Da |
| Common Vial Sizes | 2mg, 5mg, 10mg | 5mg, 10mg |
Price History
5 data points- OF
- BM
- Unknown
- VANDL Labs
- LB
- Ion Peptide
Price History
3 data points- OF
- VANDL Labs
- Ion Peptide
TB-500 (Thymosin Beta-4) — potential benefits
- Accelerated dermal wound healing through enhanced keratinocyte and fibroblast migration, collagen deposition, and angiogenesis, including in diabetic and aged models (PMID: 12581423)
- Cardioprotection and tissue repair after myocardial infarction via ILK/Akt survival signaling in preclinical models (PMID: 17600280)
- Anti-inflammatory effects via NF-kB suppression and reduced pro-inflammatory cytokines (preclinical)
- Corneal wound healing and dry eye symptom improvement in topical ophthalmic (RGN-259) Phase 2 trials (PMID: 25826322)
- Enhanced hair follicle stem cell migration associated with hair growth (preclinical)
- Musculoskeletal recovery through collagen deposition and matrix remodeling (preclinical and equine data)
- Endothelial cell migration and vascular regeneration in ischemic tissues (preclinical)
Thymosin Alpha-1 (TA1) — potential benefits
- Immune enhancement
- Antiviral defense
- Cancer adjuvant therapy
- Autoimmune modulation
- Vaccine potentiation
Frequently asked
What's the difference between TB-500 (Thymosin Beta-4) and Thymosin Alpha-1 (TA1)?
TB-500 (Thymosin Beta-4) is a injury, repair & recovery that actin sequestration and cytoskeletal dynamics the primary molecular function of thymosin beta-4 (and the synthetic peptide sold as tb-500) is binding to monomeric g-actin in a 1:1…. Thymosin Alpha-1 (TA1) is a immune & inflammation that thymosin alpha-1 does not act through a single canonical receptor in the way many peptides do. its mechanism is pleiotropic, involving pattern-recognition receptors, modulation of…. The two differ in mechanism, half-life (Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure. vs ~2 hours), and typical dose range.
Which has the longer half-life, TB-500 (Thymosin Beta-4) or Thymosin Alpha-1 (TA1)?
TB-500 (Thymosin Beta-4) has a half-life of Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure.. Thymosin Alpha-1 (TA1) has a half-life of ~2 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, TB-500 (Thymosin Beta-4) or Thymosin Alpha-1 (TA1)?
Current lowest live price on BodyHackGuide: TB-500 (Thymosin Beta-4) from $29.00, Thymosin Alpha-1 (TA1) from $39.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers.
Can you stack TB-500 (Thymosin Beta-4) and Thymosin Alpha-1 (TA1)?
Stacking depends on mechanism overlap, safety profile, and goals. TB-500 (Thymosin Beta-4) and Thymosin Alpha-1 (TA1) should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is an independent research reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks — this never affects the data or pricing shown. See editorial standards and affiliate disclosure.