TB-500 vs Thymosin Alpha-1 (TA1)
Side-by-side comparison of TB-500 and Thymosin Alpha-1 (TA1): mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
TB-500
Thymosin Alpha-1 (TA1)
TB-500
TB-500 is the name the market and the FDA use for a short synthetic fragment of thymosin beta-4: the seven-amino-acid, N-acetylated actin-binding sequence Ac-LKKTETQ (residues 17 to 23). Thymosin beta-4 itself is a…
Lowest listed price: $29.00 across 8 listings
Full TB-500 profileThymosin Alpha-1 (TA1)
Thymosin alpha-1 (Tα1) is a 28-amino-acid N-acetylated peptide (N-Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn) isolated and characterized by Allan…
Lowest listed price: $39.99 across 4 listings
Full Thymosin Alpha-1 (TA1) profileSide-by-side comparison
| Attribute | TB-500 | Thymosin Alpha-1 (TA1) |
|---|---|---|
| Category | Injury, Repair & Recovery | Immune & Inflammation |
| Research Stage | Preclinical | Approved (International) |
| Mechanism of Action | Actin Sequestration and Cytoskeletal Dynamics The primary molecular function of thymosin beta-4 (and the synthetic peptide sold as TB-500) is binding to monomeric G-actin in a 1:1 complex, preventing its polymerization into F-actin filaments (PMID: 1627561).… | Thymosin alpha-1 does not act through a single canonical receptor in the way many peptides do. Its mechanism is pleiotropic, involving pattern-recognition receptors, modulation of immune cell maturation and function, and shifts in cytokine signaling patterns.… |
| Half-Life | Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure. | ~2 hours |
| Typical Dose Range | 2000-5000 mcg (2-5 mg) subcutaneous 2x weekly loading; 2000 mcg (2 mg) weekly maintenance | 1,600 mcg (1.6 mg) per injection (standard clinical dose) |
| Dosing Frequency | 2x per week during loading; 1x per week maintenance | Twice weekly (subcutaneous) - the approved Zadaxin schedule; alternatively 900 mcg daily for intensive short-term courses |
| Administration | Subcutaneous, Intramuscular | Subcutaneous |
| Side Effects | Generally well-tolerated. Occasional mild headache, nausea, or lethargy. Localized irritation at injection site. Rare: flu-like symptoms, temporary fatigue during initial use. | Tα1 has one of the most benign side-effect profiles in the peptide space, supported by 45+ years of clinical experience in approved indications. Most users experience no acute side effects beyond mild injection site discomfort. Common (5-15% of users): -… |
| Molecular Weight | 889 Da (Ac-LKKTETQ); full-length thymosin beta-4 4963 Da | 3108 Da |
| Common Vial Sizes | 2mg, 5mg, 10mg | 5mg, 10mg |
Price History
4 data points- OF
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- Half Nattys
- Ion Peptide
- Disguised Alpha
Price History
3 data points- OF
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TB-500: potential benefits
- Accelerated dermal wound healing through enhanced keratinocyte and fibroblast migration, collagen deposition, and angiogenesis, including in diabetic and aged models (PMID: 12581423)
- Cardioprotection and tissue repair after myocardial infarction via ILK/Akt survival signaling in preclinical models (PMID: 17600280)
- Anti-inflammatory effects via NF-kB suppression and reduced pro-inflammatory cytokines (preclinical)
- Corneal wound healing and dry eye symptom improvement in topical ophthalmic (RGN-259) Phase 2 trials (PMID: 25826322)
- Enhanced hair follicle stem cell migration associated with hair growth (preclinical)
- Musculoskeletal recovery through collagen deposition and matrix remodeling (preclinical and equine data)
- Endothelial cell migration and vascular regeneration in ischemic tissues (preclinical)
Thymosin Alpha-1 (TA1): potential benefits
- Immune enhancement
- Antiviral defense
- Cancer adjuvant therapy
- Autoimmune modulation
- Vaccine potentiation
Frequently asked
What's the difference between TB-500 and Thymosin Alpha-1 (TA1)?
TB-500 is a injury, repair & recovery that actin sequestration and cytoskeletal dynamics the primary molecular function of thymosin beta-4 (and the synthetic peptide sold as tb-500) is binding to monomeric g-actin in a 1:1…. Thymosin Alpha-1 (TA1) is a immune & inflammation that thymosin alpha-1 does not act through a single canonical receptor in the way many peptides do. its mechanism is pleiotropic, involving pattern-recognition receptors, modulation of…. The two differ in mechanism, half-life (Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure. vs ~2 hours), and typical dose range.
Which has the longer half-life, TB-500 or Thymosin Alpha-1 (TA1)?
TB-500 has a half-life of Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure.. Thymosin Alpha-1 (TA1) has a half-life of ~2 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, TB-500 or Thymosin Alpha-1 (TA1)?
Lowest listed price on BodyHackGuide: TB-500 from $29.00, Thymosin Alpha-1 (TA1) from $39.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack TB-500 and Thymosin Alpha-1 (TA1)?
Stacking depends on mechanism overlap, safety profile, and goals. TB-500 and Thymosin Alpha-1 (TA1) should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.