Epitalon
Bioregulator PeptidePreclinicalAlso known as: Epithalon, Epithalamin, Ala-Glu-Asp-Gly, AEDG
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in the 1980s, modeled on the natural pineal gland peptide epithalamin.
Overview
At A Glance
Mechanism of action — pharmacological summary:…
Mechanism of Action
Mechanism of action — pharmacological summary:
- Telomerase activation — in vitro and in vivo data showing increased telomerase activity in somatic cells, with corresponding telomere length increases over time
- Melatonin axis restoration — pineal gland-targeting effects, normalizes age-related decline in nocturnal melatonin secretion
- Circadian rhythm normalization — improves cortisol/melatonin diurnal cycles
- Anti-tumor activity — reduced spontaneous tumor incidence in long-term rodent studies (Khavinson lab)
- Immune modulation — restoration of age-suppressed thymic function in elderly cohorts
- Antioxidant — reduces oxidative damage markers (MDA, 8-OHdG) in aged tissues
Overview
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in the 1980s, modeled on the natural pineal gland peptide epithalamin. The most-researched compound in the Khavinson "short peptide bioregulator" family for anti-aging and longevity research.
The primary mechanism of interest is telomerase activation: in human somatic cell cultures and rodent studies, Epitalon administration is associated with increased telomerase activity and telomere elongation — a mechanism implicated in cellular aging. Clinical research in elderly Russian populations has reported improved sleep quality, melatonin restoration, and reduced age-related mortality over multi-year follow-up.
In the United States, Epitalon is not FDA-approved and is sold as research-only. The bulk of clinical research is published in Russian-language journals; English-language peer-reviewed literature is moderate.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
C14H22N4O9
Molecular Mass
390.35 g/mol
Dosing & Protocols
Unlock Dosing Protocols
Free account gets you:
- View beginner, intermediate & advanced protocols
- See weight-based dosing calculations
- Access cycle length & frequency data
2,800+ researchers already in
Research
Unlock Research Data
Free account gets you:
- Browse PubMed study summaries
- See clinical trial phases & results
- Access mechanism of action details
2,800+ researchers already in
Interactions
Interaction and contraindication data is being compiled for Epitalon. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
No listings found for Epitalon.
Related Compounds
View AllView Full Dosage Guide →
Protocols, calculator & safety for Epitalon
Related Articles
All PostsWhy Bob Built ResearchChemHQ — A Founder Interview (2026)
A short interview with Bob, the founder of ResearchChemHQ — peptide vendor since 2020. Why he started, how every batch gets HPLC + mass spec + endotoxin testing at an ISO-certified third-party lab, why domestic shipping matters, and what code REDDIT actually unlocks at checkout (10% off, stackable with their volume tiers up to 40%).
5/8/2026The Best Peptide Nasal Sprays of 2026, Ranked by Evidence
Evidence-tiered review of 10 peptide nasal sprays — Semax, Selank, Oxytocin (S); PT-141, DSIP, Epithalon (A); Noopept, NAD+, 5-Amino-1MQ (B); Melanotan-II (C). Human-trial counts, PMID citations, safety, dosing, and pre-made vs DIY tradeoffs. Tiers match the live pillar scorecard.
4/21/2026The Complete Peptide Reconstitution Guide — Every Peptide, Every Ratio, Every Pitfall (2026)
The master reconstitution reference for 17 peptides. BAC vs SWFI vs acetic acid, mg/mL targets, IU math on U100 syringes, storage and stability by peptide class, sterile technique, and the mistakes that destroy $60 vials. Includes worked examples for BPC-157, TB-500, GHK-Cu, semaglutide, tirzepatide, CJC-1295, ipamorelin, sermorelin, GHRPs, Melanotan II, PT-141, oxytocin, Semax, Selank, DSIP, and epithalon.
4/21/2026Research Score
47 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Quick Facts
Half-Life
~30-60 minutes (peptide; biological effects extend long beyond plasma clearance)
Molecular Weight
390.35 g/mol
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Vivid dreams
- • Sleep timing shifts in first week
Stop Use If
- Pregnancy/lactation
- Active malignancy (telomerase concern)
- Peptide allergy
- Acute autoimmune flare
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Epitalon used for in research?
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in the 1980s, modeled on the natural pineal gland peptide epithalamin. The most-researched compound in the Khavinson "short peptide bioregulator" family for anti-aging and longevity research.
The primary mechanism of interest is telomerase activation: in human somatic cell cultures and rodent studies, Epitalon administration is associated with increased telomerase activity and telomere elongation — a mechanism implicated in cellular aging. Clinical research in elderly Russian populations has reported improved sleep quality, melatonin restoration, and reduced age-related mortality over multi-year follow-up.
In the United States, Epitalon is not FDA-approved and is sold as research-only. The bulk of clinical research is published in Russian-language journals; English-language peer-reviewed literature is moderate.
What forms does Epitalon come in?
Epitalon is available in vials, capsules, and sprays forms.
How much does Epitalon cost?
Pricing varies by vendor and form.
How do I compare Epitalon vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
Research Tools
Related Compounds
View AllFree 2026 Peptide Cheat Sheet — 50 pages, PDF
Dosing, reconstitution, stacks, half-lives, and vendor trust tiers. The reference we wish we had on day one.
