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MOTS-c
Longevity & Cellular HealthPreclinicalAlso known as: MOTS-c
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome's 12S rRNA region. Discovered in 2015 by researchers at USC, it represents a paradigm shift in understanding mitochondria as active endocrine signaling organelles.
Overview
Key Takeaways
- →Insulin sensitivity
- →Exercise mimicry
- →Metabolic health
- →Half-life: ~4–6 hours
At A Glance
MOTS-c translocates from mitochondria to the nucleus in response to metabolic stress, where it regulates gene expression programs related to antioxidant defense, glucose metabolism, and folate cycle activity. It activates AMPK, driving glucose uptake and fatty acid oxidation similar to exercise. In skeletal muscle, it enhances insulin sensitivity by improving glucose transporter (GLUT4) membrane translocation. Emerging evidence suggests it also modulates inflammatory cytokines and acts as a systemic metabolic regulator.
MOTS-c translocates from mitochondria to the nucleus in response to metabolic stress, where it regulates gene expression programs related to antioxidant defense, glucose metabolism, and folate cycle activity. It activates AMPK, driving glucose uptake and fatty acid oxidation similar to exercise. In skeletal muscle, it enhances insulin sensitivity by improving glucose transporter (GLUT4) membrane translocation. Emerging evidence suggests it also modulates inflammatory cytokines and acts as a systemic metabolic regulator.
Overview
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome's 12S rRNA region. Discovered in 2015 by researchers at USC, it represents a paradigm shift in understanding mitochondria as active endocrine signaling organelles. Research focuses on metabolic regulation, insulin sensitivity, exercise mimicry, and longevity, with plasma levels declining with age.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
Mitochondrial open reading frame of 12S rRNA-c (MRFA-peptide)
CAS Number
1600863-63-5
Molecular Formula
C104H181N33O28S
Molecular Mass
2174.39 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Active cancer. Severe diabetes without monitoring. Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$44.99
up to $175.00
$4.3750
4
5
vial
Price History
2 data pointsResearch Score
163 PubMed studies
Quality Indicators
Data Completeness
100%COA Verification
10
Verified COAs
2
Vendors w/ COA
High verification rate (83%)
Latest test: 3/1/2026
Research Credibility
Well-researched compound
Quick Facts
Half-Life
~4–6 hours
Molecular Weight
2174.39 g/mol
Administration
Subcutaneous, Intramuscular
CAS Number
1600863-63-5
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Mild injection site reactions
- • Transient fatigue (initial doses)
Stop Use If
- Insufficient long-term data — use caution with active diseases
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is MOTS-c used for in research?
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome's 12S rRNA region. Discovered in 2015 by researchers at USC, it represents a paradigm shift in understanding mitochondria as active endocrine signaling organelles. Research focuses on metabolic regulation, insulin sensitivity, exercise mimicry, and longevity, with plasma levels declining with age.
What forms does MOTS-c come in?
MOTS-c is available in vial form.
How much does MOTS-c cost?
Prices start at $44.99 across 4 verified vendors.
How do I compare MOTS-c vendors?
Compare prices, payment methods, shipping, and COA scores across 4 vendors.