Pinealon vs Epithalon
Independent, side-by-side comparison of Pinealon and Epithalon: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.
Live price snapshot
Pinealon
Epithalon
Pinealon
Pinealon is a synthetic tripeptide — glutamyl-aspartyl-arginine (Glu-Asp-Arg, or EDR) — developed by the St Petersburg Institute of Bioregulation and Gerontology (IBG) under the leadership of Professor Vladimir…
Live lowest price: $36.99 across 2 vendors
Full Pinealon profileEpithalon
Epithalon (also spelled Epitalon, sequence Ala-Glu-Asp-Gly / AEDG) is a synthetic tetrapeptide designed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology in the 1980s as a…
Live lowest price: $34.99 across 5 vendors
Full Epithalon profileSide-by-side comparison
| Attribute | Pinealon | Epithalon |
|---|---|---|
| Category | Nootropics | Longevity & Cellular Health |
| Research Stage | Preclinical | Preclinical (Western standards); Used clinically in Russian gerontological medicine |
| Mechanism of Action | The proposed mechanism of Pinealon is rooted in the Khavinson school's broader theory of short-peptide tissue-specific bioregulation. The full theory is worth understanding because it underlies all twelve Russian bioregulator compounds in this catalog. The… | Epithalon's mechanism is best understood as pineal peptide mimesis, operating through three parallel pathways: 1. Telomerase activation and telomere elongation The landmark finding is that 10 ng/mL AEDG in human fetal fibroblast cultures increased hTERT mRNA… |
| Half-Life | — | ~4 hours (estimated from peptide pharmacokinetic modeling; functional gene expression effects persist 24+ hours) |
| Typical Dose Range | 10 mg oral capsule, 1-2 daily for 10-30 days | 5000-10000 mcg (5-10 mg) subcutaneous daily for 10-20 day cycles; typically repeated 1-2 times per year in anti-aging protocols |
| Dosing Frequency | — | Once daily for 10–20 day cycles |
| Administration | — | Subcutaneous |
| Side Effects | The side-effect profile of Pinealon, based on the available Russian clinical literature and user-reported experience, is described as mild and uncommon. Whether this reflects genuinely low toxicity or inadequate reporting in the available studies is a… | Expected / benign - Mild injection-site reaction — redness, slight tenderness, occasional small bruise. Resolves within 24-48 hours. - Enhanced, more vivid dreams in the first week of a cycle — consistent with melatonin rise. - Deeper sleep onset and feeling… |
| Molecular Weight | 417.39 g/mol | 390.3 Da |
| Common Vial Sizes | — | 10mg, 50mg |
Price History
3 data points- VANDL Labs
- GetMelts
- Ion Peptide
Price History
3 data points- VANDL Labs
- Adera
- Ion Peptide
Pinealon — potential benefits
- Pineal gland function restoration
- Improved circadian rhythm regulation
- Enhanced natural melatonin production
- Anti-aging neuroendocrine support
- Sleep quality improvement
Epithalon — potential benefits
- Telomerase activation and telomere elongation (in vitro)
- Restoration of nocturnal melatonin secretion
- Improved sleep architecture and circadian amplitude
- Life-span extension (~30% in rodent models)
- Reduced spontaneous tumor incidence (rodent)
- Interferon-╬│ upregulation (immune rejuvenation)
- Direct chromatin / DNA binding (epigenetic modulation)
- Reduced chromosomal aberrations in aged tissue
Frequently asked
What's the difference between Pinealon and Epithalon?
Pinealon is a nootropics that the proposed mechanism of pinealon is rooted in the khavinson school's broader theory of short-peptide tissue-specific bioregulation. the full theory is worth understanding because…. Epithalon is a longevity & cellular health that epithalon's mechanism is best understood as pineal peptide mimesis, operating through three parallel pathways: 1. telomerase activation and telomere elongation the landmark finding…. The two differ in mechanism, half-life (not reported vs ~4 hours (estimated from peptide pharmacokinetic modeling; functional gene expression effects persist 24+ hours)), and typical dose range.
Which has the longer half-life, Pinealon or Epithalon?
Pinealon has a half-life of not reported. Epithalon has a half-life of ~4 hours (estimated from peptide pharmacokinetic modeling; functional gene expression effects persist 24+ hours). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Pinealon or Epithalon?
Current lowest live price on BodyHackGuide: Pinealon from $36.99, Epithalon from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers.
Can you stack Pinealon and Epithalon?
Stacking depends on mechanism overlap, safety profile, and goals. Pinealon and Epithalon should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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