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Uridine Monophosphate (UMP)
NootropicsPreclinicalUridine Monophosphate is a pyrimidine nucleotide and key component of the CDP-choline pathway, essential for neuronal membrane phospholipid synthesis. In nootropic use, it is valued for its role in dopamine receptor upregulation (D2/D3), synaptic plasticity enhancement, and mood stabilization.
Overview
Key Takeaways
- →D2/D3 receptor upregulation
- →Mood stabilization
- →Memory improvement
At A Glance
Uridine provides the uridine component of CDP-choline (CTP + choline), directly feeding into phosphatidylcholine synthesis for neuronal membrane maintenance and repair. Crucially, uridine supplementation upregulates dopamine D2 and D3 receptor expression in the striatum — the opposite of dopaminergic overstimulation which causes downregulation. This receptor sensitization produces gradual mood improvements rather than acute stimulation. Uridine also enhances neurite outgrowth and spine density through mTOR-independent pathways, suggesting long-term synaptic structural benefits.
Uridine provides the uridine component of CDP-choline (CTP + choline), directly feeding into phosphatidylcholine synthesis for neuronal membrane maintenance and repair. Crucially, uridine supplementation upregulates dopamine D2 and D3 receptor expression in the striatum — the opposite of dopaminergic overstimulation which causes downregulation. This receptor sensitization produces gradual mood improvements rather than acute stimulation. Uridine also enhances neurite outgrowth and spine density through mTOR-independent pathways, suggesting long-term synaptic structural benefits.
Overview
Uridine Monophosphate is a pyrimidine nucleotide and key component of the CDP-choline pathway, essential for neuronal membrane phospholipid synthesis. In nootropic use, it is valued for its role in dopamine receptor upregulation (D2/D3), synaptic plasticity enhancement, and mood stabilization. A core component of the 'Mr. Happy Stack' (UMP + Fish Oil + Alpha-GPC), one of the most evidence-backed long-term nootropic protocols.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl} dihydrogen phosphate
CAS Number
58-97-9
Molecular Formula
C9H13N2O9P
Molecular Mass
324.18 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Gout (uridine can increase uric acid). Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
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Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
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Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
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View Full Dosage Guide →
Protocols, calculator & safety for Uridine Monophosphate (UMP)
Research Score
5021 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Well-researched compound
Quick Facts
Molecular Weight
324.18 g/mol
CAS Number
58-97-9
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Mild headache (especially without choline source)
- • Nausea (high doses)
- • Fatigue if choline is insufficient
Stop Use If
- Gout or hyperuricemia — uridine metabolism increases uric acid precursors
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Uridine Monophosphate (UMP) used for in research?
Uridine Monophosphate is a pyrimidine nucleotide and key component of the CDP-choline pathway, essential for neuronal membrane phospholipid synthesis. In nootropic use, it is valued for its role in dopamine receptor upregulation (D2/D3), synaptic plasticity enhancement, and mood stabilization. A core component of the 'Mr. Happy Stack' (UMP + Fish Oil + Alpha-GPC), one of the most evidence-backed long-term nootropic protocols.
What forms does Uridine Monophosphate (UMP) come in?
Uridine Monophosphate (UMP) is available in vials, capsules, and sprays forms.
How much does Uridine Monophosphate (UMP) cost?
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Research Tools
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
Nootropics
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
Nootropics
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.