
Dihexa
NootropicsPreclinicalAlso known as: PNB-0408
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models.
Overview
At A Glance
Dihexa binds to the hepatocyte growth factor (HGF) receptor c-Met and potentiates HGF signaling. This drives synaptogenesis — the formation of new synaptic connections — in the hippocampus and prefrontal cortex. HGF/c-Met signaling promotes dendritic spine density, axonal sprouti…
Overview
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models. Exclusively used by the research and biohacking community with no human clinical trial data available.
Potential Research Fields
Chemical Information
IUPAC Name
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
CAS Number
1191170-93-0
Molecular Formula
C27H44N4O5
Molecular Mass
504.7 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Neurodegenerative diseases with active degeneration (unknown interaction). Pregnancy or breastfeeding. History of seizures. Concurrent use of other potent nootropics without titration.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$49.99
$4.9990
1
1
vial
Vendors Selling Dihexa
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Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
NootropicsPreclinical9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Bromantane
NootropicsRussia ApprovedBromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten.
Kavain
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L-Theanine
NootropicsFDA ApprovedL-Theanine is a non-proteinogenic amino acid found almost exclusively in tea (Camellia sinensis) and a handful of edible mushrooms, and it has become the single most widely-used calm-focus nootropic in the modern supplement market — both on its own at 100-400mg doses and, even more prominently, as the classic 1:1 or 2:1 pair with caffeine that defines the "calm-focus" experiential signature of green tea and of virtually every serious nootropic stack.
L-Tyrosine
NootropicsPreclinicalL-Tyrosine is a non-essential aromatic amino acid and the direct biosynthetic precursor to the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine.
Lion's Mane Mushroom
NootropicsPhase 2Lion's Mane (scientific name Hericium erinaceus; also known as yamabushitake in Japanese, houtou in Chinese, bearded tooth fungus, monkey head mushroom, and pom pom mushroom) is a white-to-cream coloured edible and medicinal mushroom in the tooth fungus family (Hericiaceae), characterised by its distinctive cascading spines that resemble a lion's mane or white cascading icicles.
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Protocols, calculator & safety for Dihexa
Research Score
1 PubMed studies
Quality Indicators
Data Completeness
100%Research Credibility
Limited research available
Quick Facts
Half-Life
Unknown in humans (animal studies suggest rapid metabolism with sustained CNS effects)
Molecular Weight
504.7 g/mol
Administration
Oral, Intranasal, Subcutaneous
CAS Number
1191170-93-0
Trial Phase
Preclinical
Safety Profile
Moderate RiskCommon Side Effects
- • Unknown — no human safety data exists
- • Reported: headache, fatigue, vivid dreams in anecdotal reports
Stop Use If
- CRITICAL: Active cancer or cancer history — HGF/c-Met is a known oncogenic pathway. Do not use without medical supervision
- Insufficient human data for any indication
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Dihexa used for in research?
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models. Exclusively used by the research and biohacking community with no human clinical trial data available.
What forms does Dihexa come in?
Dihexa is available in vial form.
How much does Dihexa cost?
Prices start at $49.99 across 1 verified vendor.
How do I compare Dihexa vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
NootropicsPreclinical9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Bromantane
NootropicsRussia ApprovedBromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten.
Kavain
NootropicsPreclinicalActive compound from kava for relaxation and sleep support..
L-Theanine
NootropicsFDA ApprovedL-Theanine is a non-proteinogenic amino acid found almost exclusively in tea (Camellia sinensis) and a handful of edible mushrooms, and it has become the single most widely-used calm-focus nootropic in the modern supplement market — both on its own at 100-400mg doses and, even more prominently, as the classic 1:1 or 2:1 pair with caffeine that defines the "calm-focus" experiential signature of green tea and of virtually every serious nootropic stack.
L-Tyrosine
NootropicsPreclinicalL-Tyrosine is a non-essential aromatic amino acid and the direct biosynthetic precursor to the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine.
Lion's Mane Mushroom
NootropicsPhase 2Lion's Mane (scientific name Hericium erinaceus; also known as yamabushitake in Japanese, houtou in Chinese, bearded tooth fungus, monkey head mushroom, and pom pom mushroom) is a white-to-cream coloured edible and medicinal mushroom in the tooth fungus family (Hericiaceae), characterised by its distinctive cascading spines that resemble a lion's mane or white cascading icicles.
Side-by-Side Comparisons
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