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    Dihexa molecular structure

    Dihexa

    NootropicsPreclinical

    Also known as: PNB-0408

    Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models.

    Half-Life: Unknown in humans (animal studies suggest rapid metabolism with sustained CNS effects)Route: Oral, Intranasal, SubcutaneousMW: 504.7 g/molCAS: 1191170-93-01 PubMed Studies
    Last reviewed:
    1
    PubMed Studies
    Nootropics
    Category
    Preclinical
    Research Stage

    Overview

    Best Price Available

    Limitless Biochem EU logo

    Limitless Biochem EU

    $49.99

    1 vial · vial

    Coupon:BODYHACKGUIDE

    At A Glance

    Mechanism

    Dihexa binds to the hepatocyte growth factor (HGF) receptor c-Met and potentiates HGF signaling. This drives synaptogenesis — the formation of new synaptic connections — in the hippocampus and prefrontal cortex. HGF/c-Met signaling promotes dendritic spine density, axonal sprouti

    Half-Life
    Unknown in humans (animal studies suggest rapid metabolism with sustained CNS effects)
    Dosing
    Once daily, typically morning
    Dose Range
    10–40 mg oral or intranasal per daymcg
    Routes
    OralIntranasalSubcutaneous
    Common Vials
    50mgmg100mgmg
    Potential Benefits
    Extreme synaptogenesisMemory enhancementCognitive restorationSocial behavior improvementPotential Alzheimer's application
    Safety Notes
    Common
    Unknown — no human safety data existsReported: headache, fatigue, vivid dreams in anecdotal reports

    Overview

    Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models. Exclusively used by the research and biohacking community with no human clinical trial data available.

    Potential Research Fields

    Alzheimer's diseaseCognitive impairmentSynaptogenesisNeurodegeneration

    Chemical Information

    IUPAC Name

    N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

    CAS Number

    1191170-93-0

    Molecular Formula

    C27H44N4O5

    Molecular Mass

    504.7 g/mol

    Dosing & Protocols

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    Research

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    Interactions

    Interaction Matrix

    Contraindications

    Neurodegenerative diseases with active degeneration (unknown interaction). Pregnancy or breastfeeding. History of seizures. Concurrent use of other potent nootropics without titration.

    Research Disclaimer

    This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

    Best Price

    $49.99

    Best $/mg

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    Vendors

    1

    Listings

    1

    vial

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    Limitless Biochem EU logo
    Limitless Biochem EU
    70
    🇺🇸US🇪🇺EU🇬🇧UK🇦🇺AU
    Dihexa 10mg vial 1 vial● In Stock $49.99BEST $4.999

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    Protocols, calculator & safety for Dihexa

    Best Price

    Limitless Biochem EU logo

    Limitless Biochem EU

    $49.99

    1 vendors · 1 listings

    Research Score

    60

    1 PubMed studies

    Quality Indicators

    Data Completeness

    100%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Studies
    Interactions
    Vendor Listings

    Research Credibility

    1PubMed studies

    Limited research available

    Quick Facts

    Half-Life

    Unknown in humans (animal studies suggest rapid metabolism with sustained CNS effects)

    Molecular Weight

    504.7 g/mol

    Administration

    Oral, Intranasal, Subcutaneous

    CAS Number

    1191170-93-0

    Trial Phase

    Preclinical

    Safety Profile

    Moderate Risk

    Common Side Effects

    • Unknown — no human safety data exists
    • Reported: headache, fatigue, vivid dreams in anecdotal reports

    Stop Use If

    • CRITICAL: Active cancer or cancer history — HGF/c-Met is a known oncogenic pathway. Do not use without medical supervision
    • Insufficient human data for any indication

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is Dihexa used for in research?

    Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models. Exclusively used by the research and biohacking community with no human clinical trial data available.

    What forms does Dihexa come in?

    Dihexa is available in vial form.

    How much does Dihexa cost?

    Prices start at $49.99 across 1 verified vendor.

    How do I compare Dihexa vendors?

    Compare prices, payment methods, shipping, and COA scores across 1 vendor.

    Research Tools

    Related Compounds

    View All

    9-MBC (9-Methyl-β-carboline)

    NootropicsPreclinical

    9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.

    5 mg - 30 mg daily (oral/sublingual)
    6 studiesView Profile

    Bromantane

    NootropicsRussia Approved

    Bromantane is an atypical psychostimulant and anxiolytic developed in the 1980s at the Zakusov Institute of Pharmacology of the Russian Academy of Medical Sciences, originally created as an adaptogen for Soviet military and elite athletic use and later approved in Russia for the treatment of neurasthenic and asthenic disorders under the trade name Ladasten.

    34 studiesView Profile

    Kavain

    NootropicsPreclinical

    Active compound from kava for relaxation and sleep support..

    PreclinicalView Profile

    L-Theanine

    NootropicsFDA Approved

    L-Theanine is a non-proteinogenic amino acid found almost exclusively in tea (Camellia sinensis) and a handful of edible mushrooms, and it has become the single most widely-used calm-focus nootropic in the modern supplement market — both on its own at 100-400mg doses and, even more prominently, as the classic 1:1 or 2:1 pair with caffeine that defines the "calm-focus" experiential signature of green tea and of virtually every serious nootropic stack.

    t½ 1-3 hours (plasma); central CNS effect 3-5 hours
    1226 studiesView Profile

    L-Tyrosine

    NootropicsPreclinical

    L-Tyrosine is a non-essential aromatic amino acid and the direct biosynthetic precursor to the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine.

    8 studiesView Profile

    Lion's Mane Mushroom

    NootropicsPhase 2

    Lion's Mane (scientific name Hericium erinaceus; also known as yamabushitake in Japanese, houtou in Chinese, bearded tooth fungus, monkey head mushroom, and pom pom mushroom) is a white-to-cream coloured edible and medicinal mushroom in the tooth fungus family (Hericiaceae), characterised by its distinctive cascading spines that resemble a lion's mane or white cascading icicles.

    554 studiesView Profile

    Side-by-Side Comparisons

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