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Dihexa
NootropicsPreclinicalAlso known as: PNB-0408
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models.
Overview
Key Takeaways
- →Extreme synaptogenesis
- →Memory enhancement
- →Cognitive restoration
- →Half-life: Unknown in humans (animal studies suggest rapid metabolism with sustained CNS effects)
At A Glance
Dihexa binds to the hepatocyte growth factor (HGF) receptor c-Met and potentiates HGF signaling. This drives synaptogenesis — the formation of new synaptic connections — in the hippocampus and prefrontal cortex. HGF/c-Met signaling promotes dendritic spine density, axonal sprouting, and synaptic strengthening through downstream PI3K/Akt and MAPK/ERK activation. Unlike BDNF, which acts on TrkB receptors, Dihexa's HGF mechanism represents a completely distinct pathway for enhancing synaptic connectivity.
Dihexa binds to the hepatocyte growth factor (HGF) receptor c-Met and potentiates HGF signaling. This drives synaptogenesis — the formation of new synaptic connections — in the hippocampus and prefrontal cortex. HGF/c-Met signaling promotes dendritic spine density, axonal sprouting, and synaptic strengthening through downstream PI3K/Akt and MAPK/ERK activation. Unlike BDNF, which acts on TrkB receptors, Dihexa's HGF mechanism represents a completely distinct pathway for enhancing synaptic connectivity.
Overview
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models. Exclusively used by the research and biohacking community with no human clinical trial data available.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
CAS Number
1191170-93-0
Molecular Formula
C24H38N4O4
Molecular Mass
450.58 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Neurodegenerative diseases with active degeneration (unknown interaction). Pregnancy or breastfeeding. History of seizures. Concurrent use of other potent nootropics without titration.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$44.99
up to $49.99
$4.9990
2
2
vial
| Vendor | Product | Form | Qty | Price | $/mg | Coupon | |
|---|---|---|---|---|---|---|---|
 |
Dihexa 5mg | vial | 1 vial● In Stock | $44.99BEST | $8.998 | ||
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Dihexa 10mg | vial | 1 vial● In Stock | $49.99VALUE | $4.999 |
Vendors Selling Dihexa
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Lion's Mane Mushroom
Nootropics
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.
Noopept
Nootropics
Noopept (GVS-111) is a synthetic dipeptide nootropic developed in Russia and approved there as a cognitive enhancer.
Research Score
1 PubMed studies
Quality Indicators
Data Completeness
100%Research Credibility
Limited research available
Quick Facts
Half-Life
Unknown in humans (animal studies suggest rapid metabolism with sustained CNS effects)
Molecular Weight
450.58 g/mol
Administration
Oral, Intranasal, Subcutaneous
CAS Number
1191170-93-0
Trial Phase
Preclinical
Safety Profile
Moderate RiskCommon Side Effects
- • Unknown — no human safety data exists
- • Reported: headache, fatigue, vivid dreams in anecdotal reports
Stop Use If
- CRITICAL: Active cancer or cancer history — HGF/c-Met is a known oncogenic pathway. Do not use without medical supervision
- Insufficient human data for any indication
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Dihexa used for in research?
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University. It is considered one of the most potent cognitive enhancers ever tested in animal models — reportedly 7 orders of magnitude more potent than BDNF at improving cognitive performance in rodent Alzheimer's models. Exclusively used by the research and biohacking community with no human clinical trial data available.
What forms does Dihexa come in?
Dihexa is available in vial form.
How much does Dihexa cost?
Prices start at $44.99 across 2 verified vendors.
How do I compare Dihexa vendors?
Compare prices, payment methods, shipping, and COA scores across 2 vendors.
Research Tools
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Lion's Mane Mushroom
Nootropics
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.
Noopept
Nootropics
Noopept (GVS-111) is a synthetic dipeptide nootropic developed in Russia and approved there as a cognitive enhancer.