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    Adamax

    Nootropic Peptide

    Status
    Preclinical / Research compound, , not approved for human use
    Evidence

    No data under this name, graded on 2 research benches

    Adamax is sold as an adamantane-modified Semax analogue. No peer-reviewed paper describes a peptide of this name: a PubMed search returns 39 records, none of them about a peptide.

    Reviewed

    01Overview

    What Adamax is

    PubChem has no compound record, only one vendor-deposited substance record (SID 513899171) listing Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly-OH, which differs from the sequence this guide printed and from the store listing's formula; ClinicalTrials.gov has no entry. Vendor and community write-ups give it a sequence and describe BDNF and dopamine D2 effects; nothing published stands behind either. The certificate for the lot is the only document that can say what the molecule is, and it has to print a sequence and a mass to do that.

    How it works

    BDNF and TrkB Receptor Pathway

    Adamax is reported to upregulate brain-derived neurotrophic factor (BDNF) expression in the hippocampus and modulate the sensitivity of TrkB receptors (the primary BDNF receptor). BDNF is a master regulator of neuronal plasticity, dendritic spine formation, and long-term potentiation - the molecular substrate of memory formation. The TrkB sensitivity boost is the proposed mechanism for the cognitive and mood-stabilizing effects observed at research doses.

    Read the full mechanismShow less

    Dopamine D2 Receptor Modulation

    Adamax is reported to modulate D2 receptor sensitivity in the ventral tegmental area and nucleus accumbens - the central motivation and reward circuits. This dopaminergic modulation overlaps with Semax's reported effects on the same system but is described as more sustained, hypothesized to result from the adamantane modification.

    Blood-Brain Barrier Penetration

    The adamantane structural element is shared with several CNS-acting drugs (e.g., amantadine, memantine) where it confers improved BBB permeability versus parent compounds. In Adamax, this modification is hypothesized to increase the fraction of peripherally administered peptide reaching central targets - meaning lower nasal or subcutaneous doses can produce comparable central effects to higher doses of unmodified Semax.

    Duration of Effect (Community-Reported)

    Community reports describe a subjectively long duration of effect (anecdotally ~2-3 days), supporting once-daily or every-other-day dosing; no receptor-occupancy or pharmacokinetic data exist. This subjective duration is described as considerably longer than the ~30-60 minute serum half-life of intranasal Semax and is one of the primary differentiators in the community comparison to Semax and Selank.

    Studied for

    • Cognitive enhancement
    • BDNF research
    • Dopaminergic modulation
    • Nootropic peptides
    • Blood-brain barrier

    Benefits listed

    • BDNF and TrkB receptor sensitivity upregulation in hippocampal models
    • Dopaminergic D2 receptor modulation in motivation circuits (VTA / nucleus accumbens)
    • Improved blood-brain-barrier penetration vs. standard Semax (adamantane modification)
    • Subjectively long duration of effect (anecdotally ~2-3 days) supporting every-other-day dosing (no pharmacokinetic data)
    Show 3 moreShow less
    • Cognitive enhancement reported in community protocols (focus, memory consolidation)
    • Mood stabilization and motivation effects (anecdotal)
    • No reported tolerance buildup at standard 4-8 week cycles

    02Research

    Free with email

    What the research shows

    Graded on 2 research benches

    Reference pages that put Adamax next to the compounds people pair it with: roles, evidence, overlap and conflicts. No dosing. Research use only.

    Unlock the research summary

    Enter your email to keep reading. It is free, and it opens these sections on every compound page in this browser.

    • A summary of the key research
    • Safety and side effects
    • A link to the PubMed results

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    03Safety

    Adamax side effects and interactions

    Side effects

    Common

    • Mild headache during first 1-2 days of dosing (typically self-resolving)
    • Transient irritability at doses above 1 mg
    • Sleep onset delay if dosed in the evening
    • Subcutaneous injection-site irritation

    Serious events

    • No serious adverse events published in peer-reviewed literature
    • Long-term human safety data does not exist
    • Caution in individuals with bipolar disorder or psychosis history (dopaminergic modulation)

    Who should not use it

    Contraindications

    Not approved for human use. Caution in individuals with bipolar disorder, psychosis history, or active dopaminergic medication therapy. Not for use during pregnancy or breastfeeding. No safety data exists for users with active malignancy, autoimmune disease, or seizure disorders.

    Interactions

    6 pairings in our record: 4 with a caution and 2 noted as compatible or synergistic. Compatible and synergistic are notes from the record, not safety findings.

    • Semax

      Caution

      Both modulate BDNF and D2 receptors. Combining at full doses risks receptor desensitization. Use lower combined doses when stacking.

    • P-21

      Caution

      Structural family member with overlapping mechanism. Avoid simultaneous full-dose stacking.

    • Wellbutrin

      Caution

      Both affect dopaminergic signaling. Monitor for irritability or restlessness when combining.

    • MAOIs

      Caution

      Dopaminergic interactions theoretically possible. Discuss with prescribing clinician.

    • Selank

      Synergistic

      Selank's anxiolytic profile complements Adamax's motivation/cognition effects. Common stacking pair.

    • Dihexa

      Compatible

      Dihexa's synaptogenic effects pair with Adamax's BDNF upregulation for memory-focused protocols.

    This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

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    04Dosing

    Free with email

    Adamax dosage and protocols

    Dose range
    500-2000 mcg subcutaneous (community research dosing)
    Dosing
    Once daily or every-other-day (3x/week typical)
    Common vials
    2mg, 5mg, 10mg

    Unlock the dosing protocols

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    • Dose, route, how often and how long
    • A titration schedule
    • Beginner, intermediate and advanced protocols
    • Reconstitution and handling notes

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    05Prices

    Adamax prices

    1 listing from 1 vendor, opening in the Featured order.

    Pack prices
    $69.99
    Lowest per mg
    $7.00/mg
    Vendors
    1
    Listings
    1 (nasal)

    Prices as the vendors list them, last recorded 14 September 2026.

    Form
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    Adamax listings, in Featured order
    Vendor Product Price Buy

    Adamax 10mg Research Atomizer

    nasal, 1 bottle

    In stock

    $7.00/mg

    $69.99

    Lowest per mg
    Buy Adamax 10mg Research Atomizer at BHG Labs
    Vendors selling Adamax(1: trust score, certificates, payment, shipping)

    Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank. How we score these vendors

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    06Chemistry

    Chemistry and structure

    Molecular mass
    No formula or mass is established for this material. BHG Labs' listing reports C50H69N11O11S and about 1032.2 g/mol and states that no CAS number has been assigned.
    CAS number
    Not assigned (research compound, no CAS registry entry as of 2026)
    IUPAC name
    N-acetyl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-prolyl-glycyl-L-prolyl-L-alanyl-glycinamide
    Amino acid sequence
    Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly-NH2 with C-terminal adamantyl modification (acetylated N-terminus, amidated C-terminus)
    Half-life
    No pharmacokinetic data. Community reports describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; serum half-life not characterized.

    08Questions

    Frequently asked questions

    Is Adamax just Semax with a chemistry tweak, or is it actually different?

    It's a structural derivative - Semax's Ac-MEHFPGP core plus an Ala-Gly tail capped with an adamantyl group borrowed from P-21. Same primary mechanism (BDNF / TrkB / D2 modulation), but the adamantane modification is hypothesized to improve blood-brain-barrier penetration and extend the subjective duration of effect to roughly 2-3 days vs Semax's ~30-60 minute serum half-life. No pharmacokinetic data exist for Adamax, so this is a community-reported difference in duration, not a measured one. The pharmacology is similar in kind, different in duration.

    Why are there no PubMed studies for Adamax?

    Adamax was first synthesized by Ceretropic (a research-peptide vendor) circa 2016, not a Russian academic institute, so it never entered the formal Semax / Selank publication pipeline. The Russian Institute of Molecular Genetics RAS is responsible for Semax and Selank - but they did not develop Adamax. Effects are extrapolated from Semax data and community reports; primary literature under the 'Adamax' name does not exist as of 2026.

    Intranasal or subcutaneous - which route do most researchers use?

    Both are documented. Subcutaneous is more common in current research protocols because the adamantyl tail makes the molecule larger and more lipophilic than parent Semax, which slows nasal absorption. Intranasal protocols exist but require higher doses to achieve comparable central effects. Subcutaneous at 500-1500 mcg every other day is the dominant community pattern.

    How does dosing schedule differ from Semax?

    Semax is typically dosed daily (often multiple times per day) because of its short serum half-life. Adamax community protocols describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; note there are no pharmacokinetic or receptor-occupancy data behind this. Daily dosing is not necessary and may increase the risk of D2 receptor desensitization without proportionate benefit.

    Can Adamax be stacked with Semax or P-21?

    Caution. All three modulate overlapping receptor systems (BDNF / TrkB / D2). Simultaneous full-dose stacking has not been characterized in any controlled setting and risks additive receptor desensitization. If combining, conservative low-dose protocols and longer washout windows between cycles are sensible. Adamax + Selank is a more common pairing because the mechanisms (BDNF / D2 vs GABAergic / serotonergic anxiolysis) are complementary rather than overlapping.

    What does an Adamax cycle look like end-to-end?

    A typical research cycle is 4-8 weeks with at least a 2-week washout. Beginners start at 500 mcg subcutaneous every other day to assess tolerance. Intermediate users move to 750-1000 mcg three times per week. Advanced protocols cap around 1500-2000 mcg every other day. Effects build over the first 1-2 weeks; subjective plateau is typically reported at weeks 3-4.

    Are there any known safety red flags?

    There are no formal toxicology studies. Anecdotal reports cite mild side effects similar to Semax: headache (often dose-related), transient insomnia if dosed in the evening, occasional irritability or mild mood elevation. No reports of serious adverse events in the public community datasets - but this reflects underreporting in unregulated use, not formal safety clearance. Avoid in pregnancy, lactation, active psychiatric instability, and uncontrolled hypertension.

    How many vendors sell Adamax, and what does it cost per mg?

    1 of the vendors BodyHackGuide tracks list Adamax (1 listing). Among BodyHackGuide's Adamax listings recorded as in stock with a milligram count, the lowest price per milligram is $7.00/mg at BHG Labs and the median is $7.00/mg. The Adamax prices on BodyHackGuide are vendors' listed prices as BodyHackGuide last recorded them, not transactions; the most recent recorded change to a Adamax listing is dated 14 September 2026.

    Which vendors have third-party COAs for Adamax on file at BodyHackGuide?

    BodyHackGuide holds 10 third-party certificate records for Adamax, from BHG Labs. An editor has read 1 of BodyHackGuide's 10 certificate records for Adamax and recorded the laboratory, the compound and the test date as printed on each. The laboratories named on BodyHackGuide's Adamax certificate records are ILS Laboratories and Freedom Diagnostics Testing, and the newest test date on them is 27 September 2026. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor and links to each record that has its own page.

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