Adamax
Nootropic Peptide
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Cortexin
Nootropic PeptideMarketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved)Also known as: Cortexin, Cortex, Cerebral Cortex Peptides
Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. It is not FDA-approved in the US and is sold as a research peptide.
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We do not track a vendor for Cortexin yet.
Half-life: ~2-3 hours (estimated from analog peptide preparations)MW: Complex of low-molecular-weight polypeptide fractions, ~1-10…18 PubMed results
Last reviewed:
Overview
At A Glance
Mechanism
Mechanism of action — pharmacological summary:…
Half-Life
~2-3 hours (estimated from analog peptide preparations)
Safety Notes
Common
Mild injection site reaction
Mechanism of Action
Mechanism of action — pharmacological summary:
- BDNF/NGF mimetic activity — short peptides in the complex mimic endogenous neurotrophic factor signaling
- Neuroprotective — reduced excitotoxicity and oxidative damage in models of ischemia
- GABA system modulation — increased GABAergic tone in clinical EEG studies
- Cholinergic enhancement — modulates acetylcholine pathways relevant to attention
- Anti-inflammatory — suppresses microglial activation post-injury
Overview
Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions.
Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. It is not FDA-approved in the US and is sold as a research peptide. Russian-language clinical literature is extensive; English-language peer-reviewed studies are limited but growing.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
~1-10 kDa (range of constituent polypeptide fractions; Cortexin is a peptide complex with no single defined mass)
Dosing & Protocols
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Research
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Interactions
Contraindications
Per the Russian manufacturer's label (Geropharm), not from Western regulatory review:
- Known hypersensitivity to Cortexin or any component of the preparation
- Pregnancy (listed largely because of absent safety data rather than demonstrated harm)
- Lactation / breastfeeding
Caution: safety in these populations has not been established in controlled trials. These contraindications reflect the Russian product label, not FDA/EMA guidance. Cortexin is not approved for use outside Russia/CIS.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
No listings found for Cortexin.
Related Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
t½ The commonly cited ~72-hour "functional duration" is an unverified community/vendor claim, not a measured value - no pharmacokinetic study of Adalank has ever been run. The figure is extrapolated from parent Adamax marketing claims. Actual serum half-life is unknown; there is no published PK data. 200-1200 mcg per dose (intranasal or subcutaneous), 1-2x daily
PreclinicalView Profile
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
t½ No pharmacokinetic data. Community reports describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; serum half-life not characterized. 500-2000 mcg subcutaneous (community research dosing)
PreclinicalView Profile
Cerebrolysin
Nootropic PeptideClinicalCerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.
t½ ~2-4 hours (multi-component peptide mix)
85 PubMedView Profile
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
t½ ~20-30 minutes (intranasal, estimated from analog data)
3 PubMedView Profile
NA-Semax Amidate
Nootropic PeptidePreclinicalNA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule.
t½ ~30-45 minutes (estimated, longer than standard Semax)
2 PubMedView Profile
P-21
Nootropic PeptidePreclinicalP-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.
t½ Not formally characterized in published work. P021 has only been studied in rodents (oral/dietary and subcutaneous dosing); no human pharmacokinetic data exist.
4 PubMedView Profile
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Protocols, calculator & safety for Cortexin
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See the vendor scorecardResearch Score
47
18 PubMed results
Quality Indicators
Data Completeness
63%Description
Mechanism of Action
Chemical Data
Dosing Protocols
Safety Profile
PubMed Results
Interactions
Vendor Listings
Research Volume
18PubMed results
Quick Facts
Half-Life
~2-3 hours (estimated from analog peptide preparations)
Molecular Weight
~1-10 kDa (range of constituent polypeptide fractions; Cortexin is a peptide complex with no single defined mass)
Trial Phase
Marketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved)
Safety Profile
Low to Moderate RiskCommon Side Effects
- • Mild injection site reaction
Stop Use If
- Pregnancy/lactation
- Active malignancy
- Peptide allergy
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Cortexin used for in research?
Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions.
Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors. It is not FDA-approved in the US and is sold as a research peptide. Russian-language clinical literature is extensive; English-language peer-reviewed studies are limited but growing.
What forms does Cortexin come in?
Cortexin is available in vials, capsules, and sprays forms.
How much does Cortexin cost?
BodyHackGuide tracks no vendor for Cortexin yet, so no price is stated.
How do I compare Cortexin vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
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View productRelated Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
t½ The commonly cited ~72-hour "functional duration" is an unverified community/vendor claim, not a measured value - no pharmacokinetic study of Adalank has ever been run. The figure is extrapolated from parent Adamax marketing claims. Actual serum half-life is unknown; there is no published PK data. 200-1200 mcg per dose (intranasal or subcutaneous), 1-2x daily
PreclinicalView Profile
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
t½ No pharmacokinetic data. Community reports describe a subjectively long duration of effect (~2-3 days), supporting every-other-day or 3x/week dosing; serum half-life not characterized. 500-2000 mcg subcutaneous (community research dosing)
PreclinicalView Profile
Cerebrolysin
Nootropic PeptideClinicalCerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.
t½ ~2-4 hours (multi-component peptide mix)
85 PubMedView Profile
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
t½ ~20-30 minutes (intranasal, estimated from analog data)
3 PubMedView Profile
NA-Semax Amidate
Nootropic PeptidePreclinicalNA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule.
t½ ~30-45 minutes (estimated, longer than standard Semax)
2 PubMedView Profile
P-21
Nootropic PeptidePreclinicalP-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.
t½ Not formally characterized in published work. P021 has only been studied in rodents (oral/dietary and subcutaneous dosing); no human pharmacokinetic data exist.
4 PubMedView Profile
Research Benches
Reference pages that put Cortexin next to the compounds people pair it with: roles, evidence, overlap and conflicts. No dosing. Research use only.
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