NA-Semax Amidate
Nootropic PeptidePreclinicalAlso known as: NA-Semax Amide, N-Acetyl Semax Amide, NA-Semax-NH2, Acetyl-Semax-Amide
NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency leverage: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base..
Overview
At A Glance
Mechanism (inherited from NA-Semax):…
Mechanism of Action
Mechanism (inherited from NA-Semax):
- BDNF upregulation in hippocampus + cortex
- Dopaminergic enhancement (VTA → NAc)
- 5-HT and NE turnover modulation
- Anti-inflammatory (IL-6, TNF-α suppression)
Pharmacokinetic improvements (theoretical):
- N-acetyl group — blocks aminopeptidase cleavage at the N-terminus
- C-terminal amide — blocks carboxypeptidase cleavage at the C-terminus
- Net result — reportedly 2-4x longer functional duration vs. unmodified Semax (vendor + community claim, not peer-reviewed)
Overview
NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides.
The practical effect is a peptide with dosing-frequency leverage: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
C40H57N13O10
Molecular Mass
892.0 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for NA-Semax Amidate. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
No listings found for NA-Semax Amidate.
Related Compounds
View AllAdalank
Nootropic PeptidePreclinicalAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantane-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
P-21
Nootropic PeptidePreclinicalP-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.
P-21 Amidate
Nootropic PeptidePreclinicalP-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank.
Semax P-21
Nootropic PeptidePreclinicalSemax P-21 is a hybrid synthetic peptide combining structural motifs from Semax and P-21 into a single molecule.
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Protocols, calculator & safety for NA-Semax Amidate
Research Score
2 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Limited research available
Quick Facts
Half-Life
~30-45 minutes (estimated, longer than standard Semax)
Molecular Weight
892.0 g/mol
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Mild nasal irritation
Stop Use If
- Pregnancy/lactation
- Mania
- Peptide allergy
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is NA-Semax Amidate used for in research?
NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides.
The practical effect is a peptide with dosing-frequency leverage: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base.
What forms does NA-Semax Amidate come in?
NA-Semax Amidate is available in vials, capsules, and sprays forms.
How much does NA-Semax Amidate cost?
Pricing varies by vendor and form.
How do I compare NA-Semax Amidate vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
Research Tools
Related Compounds
View AllAdalank
Nootropic PeptidePreclinicalAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantane-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
P-21
Nootropic PeptidePreclinicalP-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.
P-21 Amidate
Nootropic PeptidePreclinicalP-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank.
Semax P-21
Nootropic PeptidePreclinicalSemax P-21 is a hybrid synthetic peptide combining structural motifs from Semax and P-21 into a single molecule.