NA-Semax Amidate
Nootropic PeptidePreclinicalAlso known as: NA-Semax Amide, N-Acetyl Semax Amide, NA-Semax-NH2, Acetyl-Semax-Amide
NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base..
Overview
At A Glance
Mechanism (inherited from parent Semax - the N-acetyl / C-amidate analog itself has not been directly studied):…
Mechanism of Action
Mechanism (inherited from parent Semax - the N-acetyl / C-amidate analog itself has not been directly studied):
- BDNF upregulation in hippocampus + cortex - a single intranasal dose of Semax raises hippocampal BDNF protein and TrkB expression in rodents, alongside improved learning ([Dolotov et al., 2006; PMID 16996037])
- Dopaminergic + serotonergic modulation - Semax raises striatal serotonin turnover (5-HIAA) and potentiates amphetamine-evoked striatal dopamine release in rodents ([Eremin et al., 2005; PMID 16362768])
- NE turnover modulation
- Anti-inflammatory (IL-6, TNF- suppression)
Pharmacokinetic improvements (theoretical, not measured for this analog):
- N-acetyl group - intended to block aminopeptidase cleavage at the N-terminus
- C-terminal amide - intended to block carboxypeptidase cleavage at the C-terminus
- Net result - reportedly 2-4x longer functional duration vs. unmodified Semax (vendor + community claim, not peer-reviewed)
Note: every mechanism above is extrapolated from published research on Semax itself. NA-Semax Amidate has no pharmacology or human clinical data of its own - the acetyl and amide modifications have not been separately characterized.
Overview
NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides.
The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
C40H57N13O10
Molecular Mass
~855.0 g/mol (C39H54N10O10S; monoisotopic ~854.4)
Amino Acid Sequence
Dosing & Protocols
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Research
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Interactions
Contraindications
Do not use outside of a research setting. NA-Semax Amidate is not a medicine and has not been evaluated for human use; the points below are conservative precautions, not trial-derived medical contraindications for this compound.
- Pregnancy and lactation - avoid; there are no reproductive or developmental safety data for this analog.
- Known peptide or Semax hypersensitivity - discontinue immediately if any allergic or hypersensitivity reaction occurs.
- Mania or bipolar-spectrum instability - caution; nootropic, dopaminergic-modulating peptides may theoretically aggravate activation, though this is not established for this compound.
- Concurrent CNS-active medications or stimulants - no interaction data exist for this analog; combining is untested.
These precautions are extrapolated from the parent peptide Semax and from general peptide-research safety practice, not from any published study of NA-Semax Amidate itself.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
No listings found for NA-Semax Amidate.
Related Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
Cerebrolysin
Nootropic PeptideClinicalCerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.
Cortexin
Nootropic PeptideMarketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved)Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
P-21
Nootropic PeptidePreclinicalP-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.
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Protocols, calculator & safety for NA-Semax Amidate
Related Articles
All PostsResearch Score
2 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Limited research available
Quick Facts
Half-Life
~30-45 minutes (estimated, longer than standard Semax)
Molecular Weight
~855.0 g/mol (C39H54N10O10S; monoisotopic ~854.4)
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Mild nasal irritation
Stop Use If
- Pregnancy/lactation
- Mania
- Peptide allergy
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is NA-Semax Amidate used for in research?
NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides.
The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base.
What forms does NA-Semax Amidate come in?
NA-Semax Amidate is available in vials, capsules, and sprays forms.
How much does NA-Semax Amidate cost?
Pricing varies by vendor and form.
How do I compare NA-Semax Amidate vendors?
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Research Tools
Related Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
Cerebrolysin
Nootropic PeptideClinicalCerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.
Cortexin
Nootropic PeptideMarketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved)Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
P-21
Nootropic PeptidePreclinicalP-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.
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