NA-Semax Amidate
- Status
- Preclinical, , not approved for human use
- Evidence
-
Not graded on a research bench yet
NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides.
Reviewed
01Overview
What NA-Semax Amidate is
The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base.
How it works
Mechanism (inherited from parent Semax - the N-acetyl / C-amidate analog itself has not been directly studied):
- BDNF upregulation in hippocampus + cortex - a single intranasal dose of Semax raises hippocampal BDNF protein and TrkB expression in rodents, alongside improved learning ([Dolotov et al., 2006; PMID 16996037])
- Dopaminergic + serotonergic modulation - Semax raises striatal serotonin turnover (5-HIAA) and potentiates amphetamine-evoked striatal dopamine release in rodents ([Eremin et al., 2005; PMID 16362768])
- NE turnover modulation
- Anti-inflammatory (IL-6, TNF- suppression)
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Pharmacokinetic improvements (theoretical, not measured for this analog):
- N-acetyl group - intended to block aminopeptidase cleavage at the N-terminus
- C-terminal amide - intended to block carboxypeptidase cleavage at the C-terminus
- Net result - reportedly 2-4x longer functional duration vs. unmodified Semax (vendor + community claim, not peer-reviewed)
Note: every mechanism above is extrapolated from published research on Semax itself. NA-Semax Amidate has no pharmacology or human clinical data of its own - the acetyl and amide modifications have not been separately characterized.
02Research
Free with emailWhat the research shows
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- Safety and side effects
- A link to the PubMed results
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03Safety
NA-Semax Amidate side effects and interactions
Side effects
Low riskStop use if
- Pregnancy/lactation
- Mania
- Peptide allergy
Common
- Mild nasal irritation
Less common
- Mild headache
- Initial alertness spike
Who should not use it
Contraindications
Do not use outside of a research setting. NA-Semax Amidate is not a medicine and has not been evaluated for human use; the points below are conservative precautions, not trial-derived medical contraindications for this compound.
Read all the contraindications and cautionsShow less
- Pregnancy and lactation - avoid; there are no reproductive or developmental safety data for this analog.
- Known peptide or Semax hypersensitivity - discontinue immediately if any allergic or hypersensitivity reaction occurs.
- Mania or bipolar-spectrum instability - caution; nootropic, dopaminergic-modulating peptides may theoretically aggravate activation, though this is not established for this compound.
- Concurrent CNS-active medications or stimulants - no interaction data exist for this analog; combining is untested.
These precautions are extrapolated from the parent peptide Semax and from general peptide-research safety practice, not from any published study of NA-Semax Amidate itself.
Interactions
Not in our record
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
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04Dosing
Free with emailNA-Semax Amidate dosage and protocols
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- Dose, route, how often and how long
- Beginner, intermediate and advanced protocols
- Stacking notes
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05Prices
NA-Semax Amidate prices
No listings
06Chemistry
Chemistry and structure
- Molecular formula
- C40H57N13O10
- Molecular mass
- ~855.0 g/mol (C39H54N10O10S; monoisotopic ~854.4)
- Amino acid sequence
- Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 (Ac-MEHFPGP-NH2)
08Questions
Frequently asked questions
What is NA-Semax Amidate used for in research?
NA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides.
The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule. Direct pharmacokinetic comparisons in peer-reviewed literature remain absent — this framing is honest about the evidence base.
What forms does NA-Semax Amidate come in?
NA-Semax Amidate is available in vials, capsules, and sprays forms.
How much does NA-Semax Amidate cost?
BodyHackGuide tracks no vendor for NA-Semax Amidate yet, so no price is stated.
How do I compare NA-Semax Amidate vendors?
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