Cerebrolysin
Nootropic PeptidePreclinicalAlso known as: Cerebrolysin, Cere, EVER NEURO 215, Cerebrolyzin
Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins. Used clinically in 50+ countries (notably Russia, Eastern Europe, China, Mexico) for stroke recovery, traumatic brain injury, vascular dementia, and Alzheimer's disease. In the United States, Cerebrolysin is not FDA-approved and is sold as a research-only peptide.
Overview
At A Glance
Mechanism of action — pharmacological summary:…
Mechanism of Action
Mechanism of action — pharmacological summary:
- BDNF + NGF mimetic activity — the peptide complex contains fragments that mimic brain-derived neurotrophic factor and nerve growth factor, supporting neuronal survival
- Anti-apoptotic — reduces neuronal death in models of ischemia, hypoxia, and excitotoxicity
- Anti-inflammatory — suppresses microglial activation post-injury
- Synaptic plasticity — increases long-term potentiation in hippocampal slices
- Neurogenesis support — increases proliferation of neural stem cells in subventricular zone (rodent models)
- Cholinergic enhancement — modulates acetylcholine pathways relevant to learning and memory
Overview
Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins. Used clinically in 50+ countries (notably Russia, Eastern Europe, China, Mexico) for stroke recovery, traumatic brain injury, vascular dementia, and Alzheimer's disease.
In the United States, Cerebrolysin is not FDA-approved and is sold as a research-only peptide. The published clinical literature is substantial: multiple Cochrane meta-analyses cover its use in acute ischemic stroke, dementia, and TBI rehabilitation, with mostly positive — though heterogeneous — outcomes.
Mechanism is best characterized as BDNF/NGF-mimetic + neuroprotective rather than a single targeted drug action. The peptide complex appears to mimic endogenous neurotrophic factors, supporting neuronal survival, synaptic plasticity, and regeneration in injured tissue.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
Variable (peptide complex, not single molecule)
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for Cerebrolysin. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
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Related Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
Cortexin
Nootropic PeptidePreclinicalCortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
NA-Semax Amidate
Nootropic PeptidePreclinicalNA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule.
P-21
Nootropic PeptidePreclinicalP-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.
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Protocols, calculator & safety for Cerebrolysin
Research Score
85 PubMed studies
Quality Indicators
Data Completeness
63%Research Credibility
Well-researched compound
Quick Facts
Half-Life
~2-4 hours (multi-component peptide mix)
Molecular Weight
Variable (peptide complex, not single molecule)
Trial Phase
Preclinical
Safety Profile
Moderate RiskCommon Side Effects
- • Mild injection site reaction
Stop Use If
- Pregnancy/lactation
- Severe renal impairment
- Status epilepticus
- Known peptide allergy
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Cerebrolysin used for in research?
Cerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins. Used clinically in 50+ countries (notably Russia, Eastern Europe, China, Mexico) for stroke recovery, traumatic brain injury, vascular dementia, and Alzheimer's disease.
In the United States, Cerebrolysin is not FDA-approved and is sold as a research-only peptide. The published clinical literature is substantial: multiple Cochrane meta-analyses cover its use in acute ischemic stroke, dementia, and TBI rehabilitation, with mostly positive — though heterogeneous — outcomes.
Mechanism is best characterized as BDNF/NGF-mimetic + neuroprotective rather than a single targeted drug action. The peptide complex appears to mimic endogenous neurotrophic factors, supporting neuronal survival, synaptic plasticity, and regeneration in injured tissue.
What forms does Cerebrolysin come in?
Cerebrolysin is available in vials, capsules, and sprays forms.
How much does Cerebrolysin cost?
Pricing varies by vendor and form.
How do I compare Cerebrolysin vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
Research Tools
Related Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
Cortexin
Nootropic PeptidePreclinicalCortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
NA-Semax Amidate
Nootropic PeptidePreclinicalNA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule.
P-21
Nootropic PeptidePreclinicalP-21 is a synthetic cyclic dipeptide — Cyclo(L-prolyl-glycine) — derived from the Selank/Semax C-terminal Pro-Gly-Pro motif.
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