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    BPC-157 vs TB-500 (Thymosin Beta-4)

    Independent, side-by-side comparison of BPC-157 and TB-500 (Thymosin Beta-4): mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.

    BPC-157 from $29.00
    TB-500 (Thymosin Beta-4) from $29.00

    Live price snapshot

    BPC-157

    Current low
    $79.99
    as of May 28, 2026
    7-day low
    —
    no 7d data yet
    30-day low
    $79.99
    30-day change
    —
    baseline building

    TB-500 (Thymosin Beta-4)

    Current low
    $89.00
    as of Apr 22, 2026
    7-day low
    —
    no 7d data yet
    30-day low
    —
    no 30d data yet
    30-day change
    —
    baseline building

    BPC-157

    Featured

    BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) derived from a partial sequence of human gastric juice…

    Live lowest price: $29.00 across 20 vendors

    Full BPC-157 profile

    TB-500 (Thymosin Beta-4)

    Featured

    TB-500 is a synthetic peptide fragment of thymosin beta-4 (Tbeta4), a 43-amino-acid protein that is one of the most abundant intracellular actin-sequestering molecules in mammalian cells. With a molecular weight of…

    Live lowest price: $29.00 across 10 vendors

    Full TB-500 (Thymosin Beta-4) profile

    Side-by-side comparison

    Attribute BPC-157 TB-500 (Thymosin Beta-4)
    Category Injury, Repair & Recovery Injury, Repair & Recovery
    Research Stage Preclinical Phase 2 (ophthalmic)
    Mechanism of Action Nitric Oxide (NO) System Modulation BPC-157 exerts a central integrative effect through modulation of the nitric oxide system. Studies by Seiwerth et al. (2022) demonstrated that BPC-157 counteracts both NO-excess and NO-deficiency states, functioning as a… Actin Sequestration and Cytoskeletal Dynamics The primary molecular function of thymosin beta-4 (and its synthetic analog TB-500) is binding to monomeric G-actin in a 1:1 complex, preventing its polymerization into F-actin filaments. By maintaining a pool of…
    Half-Life ~4 hours (estimated from animal pharmacokinetic data) ~6 hours (estimated from animal pharmacokinetic data)
    Typical Dose Range 200-500 mcg subcutaneous 1-2x daily (community protocols); 1-10 mcg/kg in animal studies 2000-5000 mcg (2-5 mg) subcutaneous 2x weekly loading; 2000 mcg (2 mg) weekly maintenance
    Dosing Frequency Twice daily (AM and PM) for optimal serum levels; once daily acceptable 2x per week during loading; 1x per week maintenance
    Administration Subcutaneous, Oral, Intraperitoneal, Intravenous Subcutaneous, Intramuscular
    Side Effects Generally well-tolerated. Mild nausea or GI discomfort during initial use. Temporary increase in pain/inflammation at injury site (healing response). Rare: drowsiness, dizziness, mild headache. Very rare: transient changes in blood pressure. Generally well-tolerated. Occasional mild headache, nausea, or lethargy. Localized irritation at injection site. Rare: flu-like symptoms, temporary fatigue during initial use.
    Molecular Weight 1419.56 g/mol 4963 Da (full thymosin beta-4: 4921 Da)
    Common Vial Sizes 5mg, 10mg 2mg, 5mg, 10mg

    Price History

    7 data points
    • OF
    • BM
    • Nova Peptides
    • VANDL Labs
    • Adera
    • LB
    • Ion Peptide

    Price History

    5 data points
    • OF
    • BM
    • Nova Peptides
    • VANDL Labs
    • LB
    • Ion Peptide

    BPC-157 — potential benefits

    • Accelerated tendon and ligament healing with improved biomechanical strength (PMID: 30915550)
    • Gastric mucosal protection against NSAID-induced and ethanol-induced lesions (PMID: 29898088)
    • Gut healing in inflammatory bowel disease (IBD) preclinical models (PMID: 29898088)
    • Neuroprotection in dopaminergic and serotonergic neurotoxicity models (PMID: 21524250)
    • Promotion of angiogenesis via VEGFR2 upregulation in damaged tissues (PMID: 36416831)
    • Wound healing acceleration through EGR-1 and FAK-paxillin pathway activation (PMID: 21524250)
    • Growth hormone receptor upregulation enhancing local GH/IGF-1 signaling (PMID: 30175840)
    • Bidirectional nitric oxide system stabilization protecting against vascular injury (PMID: 36416831)

    TB-500 (Thymosin Beta-4) — potential benefits

    • Accelerated wound healing through enhanced cell migration and angiogenesis (PMID: 25613625)
    • Cardiac tissue protection and repair following myocardial infarction (PMID: 18286466)
    • Anti-inflammatory effects via NF-kB suppression and cytokine reduction
    • Corneal wound healing and dry eye symptom improvement (ophthalmic Phase 2)
    • Enhanced hair follicle stem cell migration promoting hair growth
    • Musculoskeletal recovery through collagen deposition and matrix remodeling
    • Endothelial cell migration and vascular regeneration in ischemic tissues
    In-depth comparison

    BPC-157 vs TB-500 (Thymosin Beta-4): the long answer

    BPC-157 is a 15-amino-acid pentadecapeptide derived from gastric protective protein — works fastest on GI mucosa, tendon, and ligament repair. TB-500 (synthetic thymosin beta-4 fragment) is broader: vascular regeneration, muscle repair, anti-inflammatory across more tissue types but slower onset. The classic stack uses both: BPC-157 for fast tendon/joint, TB-500 for muscle + circulation. Solo use depends on injury type.

    Last reviewed: May 17, 2026

    Mechanism — site-specific vs systemic

    BPC-157 (Body Protection Compound) accelerates angiogenesis through VEGF upregulation and FAK-paxillin signaling, with strongest documented effects on GI tract, tendon, and ligament cells in animal models. TB-500 is the synthetic 17-AA active fragment of thymosin beta-4; it promotes actin sequestration, cell migration, and angiogenesis broadly across vascular endothelium, muscle, and skin. Practical translation: BPC-157 hits the injury site fast and local; TB-500 builds systemic regenerative tone over weeks.

    • BPC-157: 15-AA pentadecapeptide. Strong on GI, tendon, ligament. VEGF + FAK-paxillin pathways.
    • TB-500: 17-AA thymosin beta-4 fragment. Broad: vascular, muscle, skin. Actin sequestration + migration.
    • Why the stack works: BPC-157 acts locally and fast (days); TB-500 builds systemic regeneration over 2-4 weeks. Different mechanisms, additive effects.

    What each is best for

    BPC-157 dominates for: acute tendon strains, ligament sprains, post-surgical recovery on connective tissue, GI inflammation (Crohn's adjunct in animal models), oral mucositis. TB-500 dominates for: muscle tears, post-workout systemic recovery, cardiovascular protection in animal cardiac injury models, hair/skin regeneration, and chronic widespread inflammation. For sports injuries where you don't know if it's tendon or muscle, the stack is standard practice in the research-use community.

    • BPC-157 wins on: Tendon, ligament, GI mucosa, post-surgical connective tissue, oral mucositis
    • TB-500 wins on: Muscle tears, systemic recovery, cardiovascular protection, skin/hair, chronic inflammation
    • Stack indications: Wolverine stack: BPC-157 250-500 mcg/day + TB-500 2-2.5 mg 2x/week for 4-6 week injury cycles

    Dosing — frequency matters more than total dose

    BPC-157 has a short half-life and is typically dosed daily (250-500 mcg subQ or oral) — frequency drives effect, not size of dose. TB-500 has a much longer half-life and is dosed 2-2.5 mg twice weekly during a loading phase (4-6 weeks), then 2 mg once weekly maintenance. Both work subQ injected near the injury site for acute, or any site for systemic. BPC-157 also has documented oral bioavailability for GI indications — the only injectable peptide where oral works.

    • BPC-157 dose: 250-500 mcg/day subQ (or 500-1000 mcg/day oral for GI). Inject near injury for local, abdomen for systemic.
    • TB-500 dose: Loading: 2-2.5 mg 2x/week × 4-6 weeks. Maintenance: 2 mg 1x/week.
    • Oral BPC-157: Unique among peptides — survives gastric environment because it's derived from gastric protective protein. Effective at 500-1000 mcg/day.

    Safety — strong tolerability profile both

    Neither has published human Phase trials. Animal model data spanning 20+ years shows clean toxicology profiles at multiples of typical research-use doses. Anecdotal community side effects: BPC-157 occasionally causes transient injection-site irritation and mild GI changes (especially oral); TB-500 sometimes causes dose-dependent lethargy in week 1-2 of the loading phase. No reported chronic toxicity in animal studies. Both are research-use only — not FDA-approved for any indication.

    • BPC-157 known side effects: Transient injection site irritation, mild GI changes on oral dosing — usually fade week 1-2
    • TB-500 known side effects: Lethargy/fatigue dose-dependent in loading phase. Drop dose 25% if persistent.
    • Regulatory status: Both research-use only. WADA-prohibited in competitive sport for TB-500. BPC-157 was added to WADA monitoring 2019, formally prohibited 2024.

    Cost — BPC-157 is cheaper per dose

    Research-use BPC-157 runs ~$0.30-0.80/mg via tracked vendors. At 500 mcg/day, that's ~$5-12/week. Research-use TB-500 runs ~$0.40-1.00/mg. At 5 mg/week loading, that's ~$20-40/week loading or ~$8-15/week maintenance. The Wolverine stack at 4 weeks loading runs ~$100-200 total for both molecules — cheap compared to most recovery protocols.

    • BPC-157 cost: $0.30-0.80/mg → ~$5-12/week at 500 mcg/day
    • TB-500 cost: $0.40-1.00/mg → ~$20-40/week loading, $8-15/week maintenance
    • 4-week stack total: ~$100-200 for both during loading phase

    Who chooses which

    Acute tendon or ligament injury: BPC-157 alone, 4 weeks, see if it resolves. GI flare-up or post-surgical recovery: BPC-157 (often oral for GI). Muscle tear or chronic systemic inflammation: TB-500 alone. Unknown mixed injury or wanting fastest possible recovery: stack both for 4-6 weeks. Hair/skin regeneration goal: TB-500 trumps BPC-157.

    • Choose BPC-157 if: Tendon/ligament injury, GI issues, post-op connective tissue, budget-constrained
    • Choose TB-500 if: Muscle tear, systemic recovery, skin/hair goals, chronic inflammation
    • Choose the stack if: Mixed injury, sports recovery, maximum 4-6 week protocol — published as the Wolverine stack

    Frequently asked

    What's the difference between BPC-157 and TB-500 (Thymosin Beta-4)?

    BPC-157 is a injury, repair & recovery that nitric oxide (no) system modulation bpc-157 exerts a central integrative effect through modulation of the nitric oxide system. studies by seiwerth et al. (2022) demonstrated that…. TB-500 (Thymosin Beta-4) is a injury, repair & recovery that actin sequestration and cytoskeletal dynamics the primary molecular function of thymosin beta-4 (and its synthetic analog tb-500) is binding to monomeric g-actin in a 1:1 complex,…. The two differ in mechanism, half-life (~4 hours (estimated from animal pharmacokinetic data) vs ~6 hours (estimated from animal pharmacokinetic data)), and typical dose range.

    Which has the longer half-life, BPC-157 or TB-500 (Thymosin Beta-4)?

    BPC-157 has a half-life of ~4 hours (estimated from animal pharmacokinetic data). TB-500 (Thymosin Beta-4) has a half-life of ~6 hours (estimated from animal pharmacokinetic data). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.

    Which is cheaper, BPC-157 or TB-500 (Thymosin Beta-4)?

    Current lowest live price on BodyHackGuide: BPC-157 from $29.00, TB-500 (Thymosin Beta-4) from $29.00. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers.

    Can you stack BPC-157 and TB-500 (Thymosin Beta-4)?

    Stacking depends on mechanism overlap, safety profile, and goals. BPC-157 and TB-500 (Thymosin Beta-4) should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.

    Is BPC-157 or TB-500 better for tendon injury?

    BPC-157 wins for tendon and ligament. Animal model data shows accelerated tendon-to-bone healing and ligament regeneration on BPC-157 at 250-500 mcg/day. TB-500 helps the broader recovery picture (vascular supply, anti-inflammatory) but BPC-157 is the primary mover on tendon-specific repair. Stack both if you want the fastest possible timeline.

    Can you take BPC-157 orally?

    Yes — uniquely among injectable peptides. BPC-157 is derived from gastric protective protein, so it survives the stomach environment. Oral dose 500-1000 mcg/day works for GI indications (gastritis, IBD adjunct, oral mucositis). For systemic tendon/ligament repair, subQ injection still has better bioavailability and faster onset.

    How long does TB-500 take to work?

    Subjective improvements typically start week 2 of the loading phase (4 doses of 2-2.5 mg). Objective recovery markers (range of motion, pain scores) usually improve by week 3-4. Full effect typically reached at 6 weeks. Maintain at 2 mg/week if you want to extend the regenerative effect.

    Can you stack BPC-157 and TB-500?

    Yes — this is the canonical Wolverine stack. Standard protocol: BPC-157 250-500 mcg/day + TB-500 2-2.5 mg 2x/week for 4-6 weeks. No published interaction issues. Different mechanisms (BPC-157 = local angiogenesis, TB-500 = systemic actin sequestration) make them additive rather than overlapping.

    Do BPC-157 and TB-500 show on drug tests?

    Both are WADA-prohibited in competitive sport. TB-500 has been WADA-tested since 2010s; BPC-157 added to monitoring 2019 and formally prohibited 2024. Detection windows are short (days), but enhanced tests exist for both. If you're an active competitive athlete in a WADA-tested sport, avoid both during competition and within the relevant out-of-competition window.

    See current vendor prices

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    BPC-157 prices TB-500 (Thymosin Beta-4) prices Compare all compounds

    Before you buy BPC-157 or TB-500 (Thymosin Beta-4)

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    ResearchChemHQ BPC-157 500mcg × 60 capsules bottle
    IN STOCK · COA PER BATCH

    BPC-157 Caps

    60 caps × 500mcg. HPLC + COA on every batch, ≥99% purity. Same molecule as the vials, just oral so it travels. code REDDIT stacks with their 5-vial 20% off and 10-vial 40% off tiers.

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