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    Nootropic PeptideMarketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved)

    Cortexin Dosage Guide: Protocols, Calculator & Safety

    Everything you need to know about Cortexin dosing — protocols, safety, and where to buy.

    Half-Life

    ~2-3 hours (estimated from analog peptide preparations)

    Dosage Calculator

    Calculate exact dosing for Cortexin.

    Dosing Protocols

    Beginner

    Beginner protocol

    • Dose: 10mg/day IM (lyophilized; reconstitute with saline)
    • Route: Intramuscular injection
    • Frequency: Once daily AM
    • Duration: 10-day cycles
    Standard

    Intermediate protocol

    • Dose: 10-20mg/day IM
    • Frequency: Once daily
    • Duration: 10-20 day cycles, repeat every 3-6 months
    Advanced

    Advanced protocol

    • Dose: 20mg/day IM, split as 10mg AM + 10mg PM. This is the highest dose documented in the Russian clinical literature (PMID 28635743). Doses above 20mg/day are anecdotal and undocumented, with no supporting efficacy or safety data.
    • Frequency: 2x daily (split AM/PM)
    • Duration: 10-day courses; the documented label regimen repeats a second 10-day course after a ~10-day interval, with further courses at 3-6 month intervals

    Commonly Stacked With

    Frequently stacked with Cerebrolysin for amplified neurotrophic effect, Semax for cognitive enhancement, and Pinealon for circadian rhythm support.

    Side Effects & Safety

    Reported adverse effects come almost entirely from the Russian product label and post-marketing use, not from Western controlled trials, so the true incidence is poorly characterized. - Hypersensitivity and allergic reactions (the most commonly listed reaction) - Injection-site pain, redness, or irritation (intramuscular route) - Rare: agitation, restlessness, or insomnia, especially if the evening dose is given late - Occasional headache Note: this safety information derives from the Russian manufacturer's label (Geropharm) and small Russian-language studies, not from FDA/EMA-reviewed trials.

    Contraindications

    Per the Russian manufacturer's label (Geropharm), not from Western regulatory review: - Known hypersensitivity to Cortexin or any component of the preparation - Pregnancy (listed largely because of absent safety data rather than demonstrated harm) - Lactation / breastfeeding Caution: safety in these populations has not been established in controlled trials. These contraindications reflect the Russian product label, not FDA/EMA guidance. Cortexin is not approved for use outside Russia/CIS.

    Check interactions with the Interaction Checker →

    Frequently Asked Questions

    What is the recommended Cortexin dosage?

    Dosage for Cortexin varies by protocol. Consult a qualified healthcare provider.

    How often should I take Cortexin?

    Administration frequency depends on the specific protocol. Consult current research literature.

    Does Cortexin need to be cycled?

    Cycling requirements depend on the protocol. Follow established research guidelines.

    What are Cortexin side effects?

    Reported adverse effects come almost entirely from the Russian product label and post-marketing use, not from Western controlled trials, so the true incidence is poorly characterized. - Hypersensitivity and allergic reactions (the most commonly listed reaction) - Injection-site pain, redness, or irritation (intramuscular route) - Rare: agitation, restlessness, or insomnia, especially if the evening dose is given late - Occasional headache Note: this safety information derives from the Russian manufacturer's label (Geropharm) and small Russian-language studies, not from FDA/EMA-reviewed trials.

    Where can I buy Cortexin?

    Visit our vendor directory to find trusted sources for Cortexin.

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