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Sulbutiamine
NootropicsPhase 4Sulbutiamine is a synthetic dimer of thiamine (vitamin B1) developed in Japan, sold as Arcalion. Unlike thiamine itself, sulbutiamine readily crosses the blood-brain barrier due to its lipophilic structure, specifically increasing thiamine levels in the brain and reticular formation.
Overview
Key Takeaways
- →Motivation enhancement
- →Memory improvement
- →Fatigue reduction
At A Glance
A fat-soluble derivative of thiamine (vitamin B1) that crosses the blood-brain barrier more readily. It increases thiamine levels in the brain and modulates dopamine and glutamate transmission in the prefrontal cortex, enhancing motivation and memory.
A fat-soluble derivative of thiamine (vitamin B1) that crosses the blood-brain barrier more readily. It increases thiamine levels in the brain and modulates dopamine and glutamate transmission in the prefrontal cortex, enhancing motivation and memory.
Overview
Sulbutiamine is a synthetic dimer of thiamine (vitamin B1) developed in Japan, sold as Arcalion. Unlike thiamine itself, sulbutiamine readily crosses the blood-brain barrier due to its lipophilic structure, specifically increasing thiamine levels in the brain and reticular formation. It is widely used for motivation, memory, fatigue, and as an antidepressant — with particular effectiveness for asthenia and psychogenic erectile dysfunction.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
1-[2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formyl-amino]-5-(2-methylpropanoyloxy)pentan-3-yl] 2-methylpropanoate
CAS Number
3286-46-2
Molecular Formula
C32H46N8O6S2
Molecular Mass
702.89 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Known allergy to thiamine derivatives. Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
No listings found for Sulbutiamine.
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
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Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
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CDP-Choline (Citicoline)
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Dihexa
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Lion's Mane Mushroom
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View Full Dosage Guide →
Protocols, calculator & safety for Sulbutiamine
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3/17/2026Research Score
41 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Quick Facts
Molecular Weight
702.89 g/mol
CAS Number
3286-46-2
Trial Phase
Phase 4
Safety Profile
Low RiskCommon Side Effects
- • Agitation at high doses
- • Sleep disruption if taken late
- • Mild headache
Stop Use If
- Bipolar disorder — can trigger mania
- Daily use leads to rapid tolerance — cycle strictly
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Sulbutiamine used for in research?
Sulbutiamine is a synthetic dimer of thiamine (vitamin B1) developed in Japan, sold as Arcalion. Unlike thiamine itself, sulbutiamine readily crosses the blood-brain barrier due to its lipophilic structure, specifically increasing thiamine levels in the brain and reticular formation. It is widely used for motivation, memory, fatigue, and as an antidepressant — with particular effectiveness for asthenia and psychogenic erectile dysfunction.
What forms does Sulbutiamine come in?
Sulbutiamine is available in vials, capsules, and sprays forms.
How much does Sulbutiamine cost?
Pricing varies by vendor and form.
How do I compare Sulbutiamine vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
Research Tools
Related Compounds
View All9-MBC (9-Methyl-β-carboline)
Nootropics
9-Methyl-β-carboline (9-MBC) is a synthetic β-carboline alkaloid that has gained significant interest in the nootropic community for its reported ability to promote dopaminergic neuron growth, increase dopamine synthesis enzymes, and provide neuroprotective effects against neurotoxins.
Alpha-GPC
Nootropics
Alpha-GPC (L-alpha glycerylphosphorylcholine) is a choline-containing phospholipid naturally present in the brain and found in small amounts in dairy and meat.
Bromantane
Nootropics
Bromantane (Ladasten) is an atypical psychostimulant and anxiolytic developed in Russia, approved there for asthenia.
CDP-Choline (Citicoline)
Nootropics
CDP-Choline (cytidine diphosphocholine, citicoline) is a naturally occurring nucleotide found in every cell in the body, and one of the most evidence-backed nootropics available.
Dihexa
Nootropics
Dihexa is a synthetic peptide analogue of the angiotensin IV metabolite LVV-hemorphin-7, developed at Washington State University.
Lion's Mane Mushroom
Nootropics
Lion's Mane (Hericium erinaceus) is a medicinal mushroom with a growing body of clinical evidence for cognitive enhancement, neurogenesis, and nerve repair.