P-21 Amidate
Nootropic PeptidePreclinicalAlso known as: P21 Amide, P-21 Amide, P-21-NH2, Cyclo-Pro-Gly-Amide
P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides. The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses.
Overview
At A Glance
Mechanism (inherited from P-21):…
Mechanism of Action
Mechanism (inherited from P-21):
- GABA-A receptor expression upregulation
- BDNF + NGF neurotrophic effects
- Anti-inflammatory profile (TNF-α, IL-1β suppression)
Amidate-specific:
- C-terminal amide reportedly improves resistance to carboxypeptidase
- Higher reported potency at lower doses vs. P-21 in vendor monographs
Overview
P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides.
The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
C7H11N3O2
Molecular Mass
169.18 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for P-21 Amidate. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
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Related Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
Cerebrolysin
Nootropic PeptidePreclinicalCerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.
Cortexin
Nootropic PeptidePreclinicalCortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
NA-Semax Amidate
Nootropic PeptidePreclinicalNA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule.
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Protocols, calculator & safety for P-21 Amidate
Research Score
1 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Limited research available
Quick Facts
Half-Life
~2-3 hours (estimated, longer than P-21)
Molecular Weight
169.18 g/mol
Trial Phase
Preclinical
Safety Profile
Low RiskCommon Side Effects
- • Mild fatigue at start
Stop Use If
- Pregnancy/lactation
- SSRI titration phase
- Peptide allergy
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is P-21 Amidate used for in research?
P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides.
The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form.
What forms does P-21 Amidate come in?
P-21 Amidate is available in vials, capsules, and sprays forms.
How much does P-21 Amidate cost?
Pricing varies by vendor and form.
How do I compare P-21 Amidate vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
Research Tools
Related Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
Cerebrolysin
Nootropic PeptidePreclinicalCerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.
Cortexin
Nootropic PeptidePreclinicalCortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
NA-Semax Amidate
Nootropic PeptidePreclinicalNA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule.
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