P-21 Amidate
Nootropic PeptidePreclinicalAlso known as: P21 Amide, P-21 Amide, P-21-NH2, Cyclo-Pro-Gly-Amide
P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides. The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses.
Overview
At A Glance
Mechanism (P-21 / P021):…
Mechanism of Action
Mechanism (P-21 / P021):
P-21 is a small-molecule mimetic of a biologically active region of human ciliary neurotrophic factor (CNTF) - an adamantylated peptide amide, Ac-DGGL(A)G-NH2. Its reported actions come from preclinical (rodent) studies:
- Increases brain-derived neurotrophic factor (BDNF) expression by inhibiting the leukemia inhibitory factor (LIF) signaling pathway [PMID:27400746]
- Enhances hippocampal (dentate gyrus) neurogenesis and synaptic plasticity [PMID:25046994]
- Lowers tau hyperphosphorylation indirectly: increased BDNF reduces glycogen synthase kinase-3 (GSK-3, a major tau kinase) activity [PMID:27400746]
- Blood-brain-barrier permeable and orally bioavailable, unlike native CNTF or BDNF [PMID:27400746]
On the "Amidate" label: Base P021 is already C-terminally amidated (the -NH2 in Ac-DGGL(A)G-NH2). Vendor claims that "P-21 Amidate" is a chemically distinct, more stable, or more potent form than standard P-21 are unverified marketing differentiation and are not supported by the published literature.
All evidence is from animal models - there are no human pharmacokinetic, efficacy, or safety studies. Research use only.
Overview
P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides.
The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
C7H11N3O2
Molecular Mass
592.69 g/mol
Amino Acid Sequence
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for P-21 Amidate. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
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Related Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
Cerebrolysin
Nootropic PeptideClinicalCerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.
Cortexin
Nootropic PeptideMarketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved)Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
NA-Semax Amidate
Nootropic PeptidePreclinicalNA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule.
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Protocols, calculator & safety for P-21 Amidate
Research Score
1 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Limited research available
Quick Facts
Half-Life
No established human PK - unknown. P-21 (P021) is a preclinical compound; rodent studies used chronic oral or subcutaneous dosing and demonstrated oral bioavailability and blood-brain-barrier penetration, but no validated human half-life data exist.
Molecular Weight
592.69 g/mol
Trial Phase
Preclinical
Safety Profile
Moderate RiskStop Use If
- Pregnancy or breastfeeding
- Known peptide allergy
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is P-21 Amidate used for in research?
P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides.
The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form.
What forms does P-21 Amidate come in?
P-21 Amidate is available in vials, capsules, and sprays forms.
How much does P-21 Amidate cost?
Pricing varies by vendor and form.
How do I compare P-21 Amidate vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
Research Tools
Related Compounds
View AllAdalank
Nootropic PeptidePreclinical / Research compoundAdalank is a hybrid research peptide combining structural elements of Adamax (the adamantyl-modified Semax analog) and Selank (the anxiolytic Pro-Gly-Pro tuftsin analog).
Adamax
Nootropic PeptidePreclinical / Research compoundAdamax is a synthetic nonapeptide (Ac-MEHFPGPAG-NH2) classified as a designer analog of Semax.
Cerebrolysin
Nootropic PeptideClinicalCerebrolysin is a porcine brain-derived peptide complex developed by EVER Neuro Pharma (Austria) — a low-molecular-weight neurotrophic preparation containing a mixture of free amino acids and bioactive peptides extracted from purified pig brain proteins.
Cortexin
Nootropic PeptideMarketed in Russia/CIS (Geropharm); human clinical use with limited-quality evidence (small, mostly Russian-language studies; no Western RCT; not FDA/EMA approved)Cortexin is a purified peptide preparation extracted from cattle and pig cerebral cortex tissue — a low-molecular-weight neuropeptide complex used clinically in Russia and Eastern Europe for cognitive impairment, post-stroke recovery, encephalopathy, attention disorders, and pediatric developmental conditions. Like Cerebrolysin, Cortexin is positioned as a broad-spectrum neurotrophic preparation supplying bioactive peptides that mimic endogenous neurotrophic factors.
NA-Semax
Nootropic PeptidePreclinicalNA-Semax is the N-acetyl-l-aspartyl variant of Semax — the original ACTH(4-7) Pro-Gly-Pro analog developed at the Russian Academy of Sciences in the 1990s.
NA-Semax Amidate
Nootropic PeptidePreclinicalNA-Semax Amidate is the C-terminally amidated NA-Semax — the carboxylic acid at the peptide's C-terminus is replaced with an amide group (-NH2), which is reported to further extend metabolic half-life by resisting carboxypeptidase cleavage in addition to the aminopeptidase resistance the N-acetyl group already provides. The practical effect is a peptide with dosing-frequency use: where standard Semax often requires 3-4 daily doses to maintain effect, NA-Semax Amidate is reported (in vendor monographs and community usage) to maintain subjective effects on a 1-2x daily schedule.
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