P-21 Amidate
- Status
- Preclinical, , not approved for human use
- Evidence
-
Not graded on a research bench yet
P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides.
Reviewed
01Overview
What P-21 Amidate is
The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form.
How it works
Mechanism (P-21 / P021):
P-21 is a small-molecule mimetic of a biologically active region of human ciliary neurotrophic factor (CNTF) - an adamantylated peptide amide, Ac-DGGL(A)G-NH2. Its reported actions come from preclinical (rodent) studies:
- Increases brain-derived neurotrophic factor (BDNF) expression by inhibiting the leukemia inhibitory factor (LIF) signaling pathway [PMID:27400746]
- Enhances hippocampal (dentate gyrus) neurogenesis and synaptic plasticity [PMID:25046994]
- Lowers tau hyperphosphorylation indirectly: increased BDNF reduces glycogen synthase kinase-3 (GSK-3, a major tau kinase) activity [PMID:27400746]
- Blood-brain-barrier permeable and orally bioavailable, unlike native CNTF or BDNF [PMID:27400746]
Read the full mechanismShow less
On the "Amidate" label: Base P021 is already C-terminally amidated (the -NH2 in Ac-DGGL(A)G-NH2). Vendor claims that "P-21 Amidate" is a chemically distinct, more stable, or more potent form than standard P-21 are unverified marketing differentiation and are not supported by the published literature.
All evidence is from animal models - there are no human pharmacokinetic, efficacy, or safety studies. Research use only.
02Research
Free with emailWhat the research shows
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03Safety
P-21 Amidate side effects and interactions
Side effects
Risk not establishedStop use if
- Pregnancy or breastfeeding
- Known peptide allergy
Interactions
Not in our record
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
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04Dosing
Free with emailP-21 Amidate dosage and protocols
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- Dose, route, how often and how long
- Beginner, intermediate and advanced protocols
- Stacking notes
- Additional dosage notes
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05Prices
P-21 Amidate prices
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06Chemistry
Chemistry and structure
- Molecular formula
- C7H11N3O2
- Molecular mass
- 592.69 g/mol
- Amino acid sequence
- Ac-DGGL(A)G-NH2
- Half-life
- No established human PK - unknown. P-21 (P021) is a preclinical compound; rodent studies used chronic oral or subcutaneous dosing and demonstrated oral bioavailability and blood-brain-barrier penetration, but no validated human half-life data exist.
08Questions
Frequently asked questions
What is P-21 Amidate used for in research?
P-21 Amidate is the amide-modified variant of P-21, the cyclic dipeptide derived from Selank. The C-terminal amidation is reported to further improve oral bioavailability and metabolic stability beyond what the cyclic structure alone provides.
The practical positioning: P-21 is already orally active; the amidate variant pushes that further, with vendor and community reports of higher subjective potency at equivalent doses. Peer-reviewed comparative data for the amidate form remains thin — most published P-21 research uses the unmodified cyclic form.
What forms does P-21 Amidate come in?
P-21 Amidate is available in vials, capsules, and sprays forms.
How much does P-21 Amidate cost?
BodyHackGuide tracks no vendor for P-21 Amidate yet, so no price is stated.
How do I compare P-21 Amidate vendors?
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