MOTS-c vs SS-31
Side-by-side comparison of MOTS-c and SS-31: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
MOTS-c
SS-31
MOTS-c
MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rather than nuclear DNA. It…
Lowest listed price: $44.99 across 9 listings
Full MOTS-c profileSS-31
SS-31 (elamipretide; MTP-131; formerly Bendavia; chemical sequence D-Arg-Dmt-Lys-Phe-NH2 with dimethyltyrosine at position 2) is a first-in-class aromatic-cationic tetrapeptide designed to selectively target the inner…
Lowest listed price: $72.00 across 4 listings
Full SS-31 profileSide-by-side comparison
| Attribute | MOTS-c | SS-31 |
|---|---|---|
| Category | Longevity & Cellular Health | Mitochondrial Peptides |
| Research Stage | Preclinical | Clinical/Approved |
| Mechanism of Action | A New Class of Signaling Molecule MOTS-c belongs to the mitochondrial-derived peptides (MDPs) - a class of small peptides encoded within mitochondrial DNA open reading frames that were historically thought to encode only ribosomal RNAs. The known MDPs include:… | SS-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high concentration of cardiolipin, a signature mitochondrial anionic phospholipid - to… |
| Half-Life | ~4–6 hours | ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding |
| Typical Dose Range | 5,000–10,000 mcg (5–10 mg) per injection | 20-60 mg |
| Dosing Frequency | 2-3 times per week | Once daily subcutaneous (some protocols use 5-6 days per week) |
| Administration | Subcutaneous, Intramuscular | — |
| Side Effects | Reported Effects (limited human data) - Injection site reactions — Mild erythema, transient itching at SC injection site. Site rotation minimizes. Probably the single most reported issue. - Transient fatigue — Some users report mild fatigue in the first week… | SS-31 (elamipretide) has been generally well-tolerated across clinical trials spanning over a decade of human exposure, with adverse event profiles dominated by injection site reactions rather than systemic toxicity. This favorable safety profile reflects both… |
| Molecular Weight | 2174 Da | 639.8 g/mol |
| Common Vial Sizes | 5mg, 10mg | — |
Price History
5 data points- OF
- BM
- Half Nattys
- Ion Peptide
- Disguised Alpha
- BHG Labs
Price History
2 data points- Ion Peptide
- BHG Labs
MOTS-c: potential benefits
- Insulin sensitivity
- Exercise mimicry
- Metabolic health
- Anti-aging
- Fat oxidation
- Longevity
SS-31: potential benefits
- No structured benefit list published.
Frequently asked
What's the difference between MOTS-c and SS-31?
MOTS-c is a longevity & cellular health that a new class of signaling molecule mots-c belongs to the mitochondrial-derived peptides (mdps) - a class of small peptides encoded within mitochondrial dna open reading frames that…. SS-31 is a mitochondrial peptides that ss-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high…. The two differ in mechanism, half-life (~4–6 hours vs ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding), and typical dose range.
Which has the longer half-life, MOTS-c or SS-31?
MOTS-c has a half-life of ~4–6 hours. SS-31 has a half-life of ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, MOTS-c or SS-31?
Lowest listed price on BodyHackGuide: MOTS-c from $44.99, SS-31 from $72.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack MOTS-c and SS-31?
Stacking depends on mechanism overlap, safety profile, and goals. MOTS-c and SS-31 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy MOTS-c or SS-31
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.