MGF (Mechano Growth Factor)
Anabolic PeptidePreclinical / Research peptideAlso known as: Mechano Growth Factor, IGF-1Ec, IGF-1 Ec splice variant
MGF (Mechano Growth Factor) is the local IGF-1Ec splice variant of insulin-like growth factor-1, expressed in skeletal muscle in response to mechanical loading. Native MGF has an extremely short serum half-life (5-7 minutes), so research peptide vendors typically supply PEG-MGF (polyethylene glycol-conjugated) which extends serum half-life to several days. MGF activates satellite cell proliferation and muscle stem cell recruitment more rapidly than systemic IGF-1, making it a candidate for post-exercise hyperplasia/hypertrophy protocols.
Overview
At A Glance
Skeletal muscle exposure to mechanical stress triggers alternative splicing of the IGF-1 gene to produce IGF-1Ec (MGF), distinct from the systemic IGF-1Ea variant. MGF binds to IGF-1 receptors on satellite cells, driving them out of quiescence into the cell cycle. The result: inc…
Overview
MGF (Mechano Growth Factor) is the local IGF-1Ec splice variant of insulin-like growth factor-1, expressed in skeletal muscle in response to mechanical loading. Native MGF has an extremely short serum half-life (5-7 minutes), so research peptide vendors typically supply PEG-MGF (polyethylene glycol-conjugated) which extends serum half-life to several days. MGF activates satellite cell proliferation and muscle stem cell recruitment more rapidly than systemic IGF-1, making it a candidate for post-exercise hyperplasia/hypertrophy protocols. Most peer-reviewed data is preclinical.
Potential Research Fields
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
Not yet available
Amino Acid Sequence
Dosing & Protocols
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Research
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Interactions
Contraindications
Active malignancy or cancer history (relative). Pregnancy and breastfeeding. Active diabetic ketoacidosis. Caution with concurrent IGF-1 LR3 - overlapping growth-factor activity.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
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Research Score
20 PubMed studies
Quality Indicators
Data Completeness
63%Research Credibility
Quick Facts
Half-Life
~5-7 min native; ~24-48 hours PEG-MGF
Administration
Subcutaneous, Intramuscular
Trial Phase
Preclinical / Research peptide
Safety Profile
Common Side Effects
- • Injection site irritation
- • Transient hypoglycemia
- • Mild water retention
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is MGF (Mechano Growth Factor) used for in research?
MGF (Mechano Growth Factor) is the local IGF-1Ec splice variant of insulin-like growth factor-1, expressed in skeletal muscle in response to mechanical loading. Native MGF has an extremely short serum half-life (5-7 minutes), so research peptide vendors typically supply PEG-MGF (polyethylene glycol-conjugated) which extends serum half-life to several days.
MGF activates satellite cell proliferation and muscle stem cell recruitment more rapidly than systemic IGF-1, making it a candidate for post-exercise hyperplasia/hypertrophy protocols. Most peer-reviewed data is preclinical.
What forms does MGF (Mechano Growth Factor) come in?
MGF (Mechano Growth Factor) is available in vials, capsules, and sprays forms.
How much does MGF (Mechano Growth Factor) cost?
Pricing varies by vendor and form.
How do I compare MGF (Mechano Growth Factor) vendors?
Compare prices, payment methods, shipping, and COA scores across 0 vendors.
Research Tools
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