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    MGF (Mechano Growth Factor)

    Anabolic PeptidePreclinical / Research peptide

    Also known as: Mechano Growth Factor, IGF-1Ec, IGF-1 Ec splice variant

    MGF (Mechano Growth Factor) is the local IGF-1Ec splice variant of insulin-like growth factor-1, expressed in skeletal muscle in response to mechanical loading. Native MGF has an extremely short serum half-life (5-7 minutes), so research peptide vendors typically supply PEG-MGF (polyethylene glycol-conjugated) which extends serum half-life to several days. MGF activates satellite cell proliferation and muscle stem cell recruitment more rapidly than systemic IGF-1, making it a candidate for post-exercise hyperplasia/hypertrophy protocols.

    Half-Life: Reported/estimated only; no published human PK data. Commonly cited community figures are ~5-7 minutes for native MGF and ~24-48 hours for PEGylated PEG-MGF; neither has been established in human pharmacokinetic studies.Route: Subcutaneous, IntramuscularMW: ~2868 Da (synthetic 24-amino-acid Ec / E-domain peptide, sequence YQPPSTNKNTKSQRRKGSTFEERK)20 PubMed Studies
    Last reviewed:
    20
    PubMed Studies
    Anabolic Peptide
    Category
    Preclinical / Research peptide
    Research Stage

    Overview

    At A Glance

    Mechanism

    Mechanical stress on skeletal muscle triggers alternative splicing of the IGF-1 gene, producing the IGF-1Ec variant rather than the systemic IGF-1Ea form. "MGF" refers to the ~24-amino-acid C-terminal Ec (E-domain) peptide derived from that splice variant. Contrary to a widesprea…

    Half-Life
    Reported/estimated only; no published human PK data. Commonly cited community figures are ~5-7 minutes for native MGF and ~24-48 hours for PEGylated PEG-MGF; neither has been established in human pharmacokinetic studies.
    Dosing
    Twice per week post-workout
    Dose Range
    100-300 mcg (PEG-MGF)mcg
    Routes
    SubcutaneousIntramuscular
    Common Vials
    2mgmg5mgmg
    Potential Benefits
    Proposed (preclinical / in-vitro): satellite-cell proliferation in skeletal muscleProposed: local hypertrophy and myonuclear donation to existing fibersProposed: post-exercise recovery supportProposed: tissue-repair adjunct (muscle, tendon)
    Safety Notes
    Common
    Injection site irritationTransient hypoglycemiaMild water retention
    Serious
    Theoretical risk in active malignancy (growth factor activity)No long-term human safety data

    Overview

    MGF (Mechano Growth Factor) is the local IGF-1Ec splice variant of insulin-like growth factor-1, expressed in skeletal muscle in response to mechanical loading. Native MGF has an extremely short serum half-life (5-7 minutes), so research peptide vendors typically supply PEG-MGF (polyethylene glycol-conjugated) which extends serum half-life to several days. MGF activates satellite cell proliferation and muscle stem cell recruitment more rapidly than systemic IGF-1, making it a candidate for post-exercise hyperplasia/hypertrophy protocols. Most peer-reviewed data is preclinical.

    Potential Research Fields

    Skeletal muscle hypertrophySatellite cell biologyIGF-1 splice variantsPost-exercise recovery

    Chemical Information

    IUPAC Name

    Not yet available

    CAS Number

    Not yet available

    Molecular Formula

    Not yet available

    Molecular Mass

    ~2868.2 Da (average mass, C-terminal Ec peptide)

    Amino Acid Sequence

    Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys (Ec peptide)

    Dosing & Protocols

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    Research

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    Interactions

    Contraindications

    Active malignancy or cancer history (relative). Pregnancy and breastfeeding. Active diabetic ketoacidosis. Caution with concurrent IGF-1 LR3 - overlapping growth-factor activity.

    Research Disclaimer

    This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.

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    Research Score

    47

    20 PubMed studies

    Quality Indicators

    Data Completeness

    63%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Studies
    Interactions
    Vendor Listings

    Research Credibility

    20PubMed studies

    Quick Facts

    Half-Life

    Reported/estimated only; no published human PK data. Commonly cited community figures are ~5-7 minutes for native MGF and ~24-48 hours for PEGylated PEG-MGF; neither has been established in human pharmacokinetic studies.

    Molecular Weight

    ~2868.2 Da (average mass, C-terminal Ec peptide)

    Administration

    Subcutaneous, Intramuscular

    Trial Phase

    Preclinical / Research peptide

    Safety Profile

    Common Side Effects

    • • Injection site irritation
    • • Transient hypoglycemia
    • • Mild water retention

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is MGF (Mechano Growth Factor) used for in research?

    MGF (Mechano Growth Factor) is the local IGF-1Ec splice variant of insulin-like growth factor-1, expressed in skeletal muscle in response to mechanical loading. Native MGF has an extremely short serum half-life (5-7 minutes), so research peptide vendors typically supply PEG-MGF (polyethylene glycol-conjugated) which extends serum half-life to several days.

    MGF activates satellite cell proliferation and muscle stem cell recruitment more rapidly than systemic IGF-1, making it a candidate for post-exercise hyperplasia/hypertrophy protocols. Most peer-reviewed data is preclinical.

    What forms does MGF (Mechano Growth Factor) come in?

    MGF (Mechano Growth Factor) is available in vials, capsules, and sprays forms.

    How much does MGF (Mechano Growth Factor) cost?

    Pricing varies by vendor and form.

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