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GHK-Cu
Skin, Hair & AestheticsPhase 2Also known as: Copper Peptide, GHK Copper
GHK-Cu (copper peptide GHK) is a naturally occurring tripeptide complex of glycine-histidine-lysine bound to copper (II). It exists endogenously in human plasma, urine, and saliva, with plasma concentrations declining significantly with age.
Overview
Key Takeaways
- →Skin regeneration
- →Wound healing
- →Hair growth
- →Half-life: ~30–60 minutes (rapid clearance, effects persist due to gene activation)
At A Glance
GHK-Cu modulates gene expression on a massive scale — studies show it affects 4,000+ genes, resetting many toward a younger expression pattern. It upregulates collagen synthesis (types I, III), decorin, and metalloproteinase inhibitors (TIMPs) while downregulating inflammatory cytokines. The copper ion serves as a cofactor for superoxide dismutase and lysyl oxidase, supporting antioxidant defense and collagen cross-linking. In skin, it activates dermal fibroblasts and stimulates glycosaminoglycan synthesis for improved hydration and elasticity.
GHK-Cu modulates gene expression on a massive scale — studies show it affects 4,000+ genes, resetting many toward a younger expression pattern. It upregulates collagen synthesis (types I, III), decorin, and metalloproteinase inhibitors (TIMPs) while downregulating inflammatory cytokines. The copper ion serves as a cofactor for superoxide dismutase and lysyl oxidase, supporting antioxidant defense and collagen cross-linking. In skin, it activates dermal fibroblasts and stimulates glycosaminoglycan synthesis for improved hydration and elasticity.
Overview
GHK-Cu (copper peptide GHK) is a naturally occurring tripeptide complex of glycine-histidine-lysine bound to copper (II). It exists endogenously in human plasma, urine, and saliva, with plasma concentrations declining significantly with age. Research spans wound healing, skin regeneration, hair follicle stimulation, anti-inflammatory effects, and potential anti-aging applications at the systemic level.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
glycyl-L-histidyl-L-lysine copper(II) complex
CAS Number
49557-75-7
Molecular Formula
C14H24CuN6O4
Molecular Mass
403.92 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Active liver disease (when using at high systemic doses). Wilson's disease (copper metabolism disorder). Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$34.99
up to $75.00
$0.5999
5
6
vial
Price History
2 data pointsRelated Compounds
View AllMelanotan II
Skin, Hair & Aesthetics
Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH).
PT-141 (Bremelanotide)
Skin, Hair & Aesthetics
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist FDA-approved as Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women.
Research Score
6 PubMed studies
Quality Indicators
Data Completeness
100%COA Verification
10
Verified COAs
2
Vendors w/ COA
High verification rate (83%)
Latest test: 3/1/2026
Research Credibility
Limited research available
Quick Facts
Half-Life
~30–60 minutes (rapid clearance, effects persist due to gene activation)
Molecular Weight
403.92 g/mol
Administration
Subcutaneous, Topical, Intramuscular
CAS Number
49557-75-7
Trial Phase
Phase 2
Safety Profile
Low RiskCommon Side Effects
- • Injection site redness
- • Temporary skin flushing
- • Mild irritation (topical)
Stop Use If
- Wilson's disease or copper sensitivity
- Active infection at injection site
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is GHK-Cu used for in research?
GHK-Cu (copper peptide GHK) is a naturally occurring tripeptide complex of glycine-histidine-lysine bound to copper (II). It exists endogenously in human plasma, urine, and saliva, with plasma concentrations declining significantly with age. Research spans wound healing, skin regeneration, hair follicle stimulation, anti-inflammatory effects, and potential anti-aging applications at the systemic level.
What forms does GHK-Cu come in?
GHK-Cu is available in vial form.
How much does GHK-Cu cost?
Prices start at $34.99 across 5 verified vendors.
How do I compare GHK-Cu vendors?
Compare prices, payment methods, shipping, and COA scores across 5 vendors.
Research Tools
Related Compounds
View AllMelanotan II
Skin, Hair & Aesthetics
Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH).
PT-141 (Bremelanotide)
Skin, Hair & Aesthetics
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist FDA-approved as Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women.