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Melanotan II
Skin, Hair & AestheticsPreclinicalMelanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH). It activates melanocortin receptors MC1R through MC5R with varying affinities, producing skin tanning without UV exposure, appetite suppression, and sexual arousal effects.
Overview
Key Takeaways
- →Tanning without UV
- →Appetite suppression
- →Sexual arousal
At A Glance
Melanotan II binds melanocortin receptors non-selectively: MC1R activation on melanocytes stimulates eumelanin production (tanning); MC3R/MC4R activation in the hypothalamus reduces food intake and increases sexual arousal via dopaminergic and oxytocinergic pathways; MC5R activation modulates sebaceous gland function. The cyclic structure provides enhanced receptor binding and resistance to enzymatic degradation compared to linear α-MSH.
Melanotan II binds melanocortin receptors non-selectively: MC1R activation on melanocytes stimulates eumelanin production (tanning); MC3R/MC4R activation in the hypothalamus reduces food intake and increases sexual arousal via dopaminergic and oxytocinergic pathways; MC5R activation modulates sebaceous gland function. The cyclic structure provides enhanced receptor binding and resistance to enzymatic degradation compared to linear α-MSH.
Overview
Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH). It activates melanocortin receptors MC1R through MC5R with varying affinities, producing skin tanning without UV exposure, appetite suppression, and sexual arousal effects. Never FDA-approved due to non-selective receptor binding and associated side effects. Widely used in the cosmetic biohacking community despite regulatory concerns.
Potential Benefits
Potential Research Fields
Chemical Information
IUPAC Name
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
CAS Number
121062-08-6
Molecular Formula
C50H69N15O9
Molecular Mass
1024.19 g/mol
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
History of melanoma or skin cancer. Numerous atypical moles. Pregnancy or breastfeeding.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
No listings found for Melanotan II.
Related Compounds
View AllGHK-Cu
Skin, Hair & Aesthetics
GHK-Cu (copper peptide GHK) is a naturally occurring tripeptide complex of glycine-histidine-lysine bound to copper (II).
PT-141 (Bremelanotide)
Skin, Hair & Aesthetics
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist FDA-approved as Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women.
View Full Dosage Guide →
Protocols, calculator & safety for Melanotan II
Research Score
17 PubMed studies
Quality Indicators
Data Completeness
75%Research Credibility
Quick Facts
Molecular Weight
1024.19 g/mol
CAS Number
121062-08-6
Trial Phase
Preclinical
Safety Profile
Moderate RiskCommon Side Effects
- • Nausea (especially early doses)
- • Facial flushing
- • Fatigue
- • Darkening of existing moles
- • Spontaneous erections
Stop Use If
- History of melanoma or atypical moles
- Cardiovascular disease
- Pregnancy
- Priapism episodes
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Melanotan II used for in research?
Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH). It activates melanocortin receptors MC1R through MC5R with varying affinities, producing skin tanning without UV exposure, appetite suppression, and sexual arousal effects. Never FDA-approved due to non-selective receptor binding and associated side effects. Widely used in the cosmetic biohacking community despite regulatory concerns.
What forms does Melanotan II come in?
Melanotan II is available in vials, capsules, and sprays forms.
How much does Melanotan II cost?
Pricing varies by vendor and form.
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Research Tools
Related Compounds
View AllGHK-Cu
Skin, Hair & Aesthetics
GHK-Cu (copper peptide GHK) is a naturally occurring tripeptide complex of glycine-histidine-lysine bound to copper (II).
PT-141 (Bremelanotide)
Skin, Hair & Aesthetics
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist FDA-approved as Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women.