Thymosin Alpha-1 (TA1) vs Pinealon
Side-by-side comparison of Thymosin Alpha-1 (TA1) and Pinealon: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
Thymosin Alpha-1 (TA1)
Pinealon
Thymosin Alpha-1 (TA1)
Thymosin alpha-1 (Tα1) is a 28-amino-acid N-acetylated peptide (N-Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn) isolated and characterized by Allan…
Lowest listed price: $39.99 across 4 listings
Full Thymosin Alpha-1 (TA1) profilePinealon
Pinealon is a synthetic tripeptide — glutamyl-aspartyl-arginine (Glu-Asp-Arg, or EDR) — developed by the St Petersburg Institute of Bioregulation and Gerontology (IBG) under the leadership of Professor Vladimir…
Lowest listed price: $45.00 across 3 listings
Full Pinealon profileSide-by-side comparison
| Attribute | Thymosin Alpha-1 (TA1) | Pinealon |
|---|---|---|
| Category | Immune & Inflammation | Nootropics |
| Research Stage | Approved (International) | Preclinical |
| Mechanism of Action | Thymosin alpha-1 does not act through a single canonical receptor in the way many peptides do. Its mechanism is pleiotropic, involving pattern-recognition receptors, modulation of immune cell maturation and function, and shifts in cytokine signaling patterns.… | The proposed mechanism of Pinealon is rooted in the Khavinson school's broader theory of short-peptide tissue-specific bioregulation. The full theory is worth understanding because it underlies all twelve Russian bioregulator compounds in this catalog. The… |
| Half-Life | ~2 hours | Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing. |
| Typical Dose Range | 1,600 mcg (1.6 mg) per injection (standard clinical dose) | Subcutaneous (primary route): 2-10 mg/day, typically 3-5 mg, in pulsed 10-20 day cycles, 2-4 cycles/year. Intranasal: 150-800 mcg per nostril daily. Research use only; oral dosing is not recommended because the peptide is largely degraded by GI proteases. |
| Dosing Frequency | Twice weekly (subcutaneous) - the approved Zadaxin schedule; alternatively 900 mcg daily for intensive short-term courses | Once daily during a cycle (morning preferred); some advanced users split into AM + midday doses. Not dosed continuously year-round - cycles are pulsed. |
| Administration | Subcutaneous | — |
| Side Effects | Tα1 has one of the most benign side-effect profiles in the peptide space, supported by 45+ years of clinical experience in approved indications. Most users experience no acute side effects beyond mild injection site discomfort. Common (5-15% of users): -… | The side-effect profile of Pinealon, based on the available Russian clinical literature and user-reported experience, is described as mild and uncommon. Whether this reflects genuinely low toxicity or inadequate reporting in the available studies is a… |
| Molecular Weight | 3108 Da | 418.40 g/mol (C15H26N6O8) |
| Common Vial Sizes | 5mg, 10mg | — |
Price History
3 data points- OF
- Half Nattys
- Disguised Alpha
Price History
2 data points- Ion Peptide
- Disguised Alpha
Thymosin Alpha-1 (TA1): potential benefits
- Immune enhancement
- Antiviral defense
- Cancer adjuvant therapy
- Autoimmune modulation
- Vaccine potentiation
Pinealon: potential benefits
- Neuroprotection against oxidative and hypoxic stress (preclinical models)
- Antioxidant support - reduced oxidative DNA damage in aged neurons (in vitro)
- Cognitive and memory support in aging populations (small Russian clinical reports)
- Reduced neuronal apoptosis and support of dendritic-tree integrity in cell models
- Investigated for neuroprotection in Alzheimer's-model systems (preclinical)
Frequently asked
What's the difference between Thymosin Alpha-1 (TA1) and Pinealon?
Thymosin Alpha-1 (TA1) is a immune & inflammation that thymosin alpha-1 does not act through a single canonical receptor in the way many peptides do. its mechanism is pleiotropic, involving pattern-recognition receptors, modulation of…. Pinealon is a nootropics that the proposed mechanism of pinealon is rooted in the khavinson school's broader theory of short-peptide tissue-specific bioregulation. the full theory is worth understanding because…. The two differ in mechanism, half-life (~2 hours vs Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.), and typical dose range.
Which has the longer half-life, Thymosin Alpha-1 (TA1) or Pinealon?
Thymosin Alpha-1 (TA1) has a half-life of ~2 hours. Pinealon has a half-life of Not formally characterized in humans. Short regulatory peptides of this class are cleared from plasma within minutes; the Khavinson framework proposes durable downstream gene-expression effects that outlast the brief dosing window, which is the stated rationale for pulsed cycling rather than continuous dosing.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, Thymosin Alpha-1 (TA1) or Pinealon?
Lowest listed price on BodyHackGuide: Thymosin Alpha-1 (TA1) from $39.99, Pinealon from $45.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack Thymosin Alpha-1 (TA1) and Pinealon?
Stacking depends on mechanism overlap, safety profile, and goals. Thymosin Alpha-1 (TA1) and Pinealon should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.