TB-500 vs Snap-8
Side-by-side comparison of TB-500 and Snap-8: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
TB-500
Snap-8
TB-500
TB-500 is the name the market and the FDA use for a short synthetic fragment of thymosin beta-4: the seven-amino-acid, N-acetylated actin-binding sequence Ac-LKKTETQ (residues 17 to 23). Thymosin beta-4 itself is a…
Lowest listed price: $29.00 across 8 listings
Full TB-500 profileSnap-8
Snap-8 (INCI: Acetyl Octapeptide-3) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A…
Lowest listed price: $34.99 across 4 listings
Full Snap-8 profileSide-by-side comparison
| Attribute | TB-500 | Snap-8 |
|---|---|---|
| Category | Injury, Repair & Recovery | Skin & Hair |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | Actin Sequestration and Cytoskeletal Dynamics The primary molecular function of thymosin beta-4 (and the synthetic peptide sold as TB-500) is binding to monomeric G-actin in a 1:1 complex, preventing its polymerization into F-actin filaments (PMID: 1627561).… | Snap-8 (INCI Acetyl Octapeptide-3; CAS 868844-74-0) is a synthetic octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, whose sequence mimics the N-terminal domain of SNAP-25. SNAP-25, together with Syntaxin-1 and VAMP/synaptobrevin, forms the SNARE complex… |
| Half-Life | Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure. | Not characterized (topical peptide) |
| Typical Dose Range | 2000-5000 mcg (2-5 mg) subcutaneous 2x weekly loading; 2000 mcg (2 mg) weekly maintenance | — |
| Dosing Frequency | 2x per week during loading; 1x per week maintenance | twice_daily |
| Administration | Subcutaneous, Intramuscular | Topical |
| Side Effects | Human safety is unknown: FDA's 2026 review found no clinical studies or human exposure data for TB-500 by any route. None of the effects that follow comes from a study. Occasional mild headache, nausea, or lethargy. Localized irritation at injection site.… | Topical use at cosmetic concentrations is generally well tolerated. The most commonly reported effects are mild, transient local reactions such as erythema, tightness, dryness, or stinging, usually at higher concentrations or on sensitive/periocular skin.… |
| Molecular Weight | 889 Da (Ac-LKKTETQ); full-length thymosin beta-4 4963 Da | 1075.16 g/mol |
| Common Vial Sizes | 2mg, 5mg, 10mg | 10 |
Price History
4 data points- OF
- BM
- Half Nattys
- Ion Peptide
- Disguised Alpha
Price History
3 data points- Ion Peptide
- OF
- Disguised Alpha
TB-500: potential benefits
- Accelerated dermal wound healing through enhanced keratinocyte and fibroblast migration, collagen deposition, and angiogenesis, including in diabetic and aged models (PMID: 12581423)
- Cardioprotection and tissue repair after myocardial infarction via ILK/Akt survival signaling in preclinical models (PMID: 17600280)
- Anti-inflammatory effects via NF-kB suppression and reduced pro-inflammatory cytokines (preclinical)
- Corneal wound healing and dry eye symptom improvement in topical ophthalmic (RGN-259) Phase 2 trials (PMID: 25826322)
- Enhanced hair follicle stem cell migration associated with hair growth (preclinical)
- Musculoskeletal recovery through collagen deposition and matrix remodeling (preclinical)
- Endothelial cell migration and vascular regeneration in ischemic tissues (preclinical)
Snap-8: potential benefits
- Reduction of dynamic expression wrinkles (forehead, crow's feet, glabellar lines)
- SNARE complex interference — partial, reversible neuromuscular inhibition
- Topical alternative research model for neuromuscular relaxation without injected toxin
- Cosmetic peptide compounding research — high-purity raw powder applications
- Synergy with Argireline (Acetyl Hexapeptide-3) in SNARE-targeting formulations
Frequently asked
What's the difference between TB-500 and Snap-8?
TB-500 is a injury, repair & recovery that actin sequestration and cytoskeletal dynamics the primary molecular function of thymosin beta-4 (and the synthetic peptide sold as tb-500) is binding to monomeric g-actin in a 1:1…. Snap-8 is a skin & hair that snap-8 (inci acetyl octapeptide-3; cas 868844-74-0) is a synthetic octapeptide, ac-glu-glu-met-gln-arg-arg-ala-asp-nh2, whose sequence mimics the n-terminal domain of snap-25.…. The two differ in mechanism, half-life (Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure. vs Not characterized (topical peptide)), and typical dose range.
Which has the longer half-life, TB-500 or Snap-8?
TB-500 has a half-life of Plasma half-life is short - full-length thymosin beta-4 clears on the order of hours, while the short LKKTETQ actin-binding fragment clears within minutes. Tissue-level regenerative effects persist substantially longer than plasma exposure.. Snap-8 has a half-life of Not characterized (topical peptide). Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, TB-500 or Snap-8?
Lowest listed price on BodyHackGuide: TB-500 from $29.00, Snap-8 from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack TB-500 and Snap-8?
Stacking depends on mechanism overlap, safety profile, and goals. TB-500 and Snap-8 should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy TB-500 or Snap-8
Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor.
Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.