PT-141 (Bremelanotide) vs N-Acetyl-Selank
Side-by-side comparison of PT-141 (Bremelanotide) and N-Acetyl-Selank: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
PT-141 (Bremelanotide)
N-Acetyl-Selank
PT-141 (Bremelanotide)
PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain — not peripherally on genital tissue — to improve sexual desire, arousal, and responsiveness. It is…
Lowest listed price: $34.99 across 5 listings
Full PT-141 (Bremelanotide) profileN-Acetyl-Selank
N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a tuftsin-derived heptapeptide used intranasally for its reported anxiolytic and nootropic effects. The acetyl group is claimed to improve stability and…
Lowest listed price: $79.99 across 2 listings
Full N-Acetyl-Selank profileSide-by-side comparison
| Attribute | PT-141 (Bremelanotide) | N-Acetyl-Selank |
|---|---|---|
| Category | Skin, Hair & Aesthetics | Cognitive |
| Research Stage | FDA Approved | Preclinical (the N-acetyl analog has no dedicated studies); parent Selank has limited clinical use in Russia |
| Mechanism of Action | Melanocortin Receptor Pharmacology PT-141 is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-OH) that binds the melanocortin receptor family with the following selectivity profile: | Receptor | Primary Location | PT-141 Activity |… | N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tail added to slow enzymatic breakdown.… |
| Half-Life | ~2.7 hours | Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature. |
| Typical Dose Range | 500–2,000 mcg (0.5–2 mg) per dose | 100-900 mcg |
| Dosing Frequency | As needed, 45 minutes before sexual activity; max once per 24 hours, max 8 doses/month | Once or twice daily (intranasal); some advanced users split into 2-3 doses |
| Administration | Subcutaneous | — |
| Side Effects | Very Common (10% of users) - Nausea — By far the most common adverse effect, affecting approximately 40% of users in the RECONNECT trials. Usually mild-to-moderate, begins within 30-60 minutes of injection, resolves within 2-4 hours. Can be mitigated with… | In short Russian clinical trials, parent Selank was generally well tolerated with no serious adverse effects reported [PMID:18454096]. Reported or plausible effects (largely extrapolated to the analog): mild nasal irritation or congestion from the spray,… |
| Molecular Weight | 1025.2 Da | ~793.9 g/mol (theoretical: Selank ~751.9 g/mol + N-terminal acetyl, ~+42). Approximate molecular formula C35H59N11O10. |
| Common Vial Sizes | 2mg, 10mg | — |
Price History
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PT-141 (Bremelanotide): potential benefits
- Sexual desire enhancement
- HSDD treatment
- Erectile dysfunction (central mechanism)
- Non-hormonal approach
N-Acetyl-Selank: potential benefits
- Anxiolytic (calming) effects - the most-studied action of parent Selank, including a Russian clinical trial in generalized anxiety disorder [PMID:18454096]
- Nootropic / cognitive support - reported attention and memory benefits in rodent models, linked to BDNF changes [PMID:31625062]
- Stress resilience reported without the sedation, tolerance, or dependence typically seen with benzodiazepines (preclinical framing) [PMID:30255741]
- Possible support during withdrawal states (alcohol, opioid) in animal models [PMID:24913576][PMID:36322304]
- Claimed longer duration vs. plain Selank from N-terminal acetylation - a community/vendor claim not verified in published data
Frequently asked
What's the difference between PT-141 (Bremelanotide) and N-Acetyl-Selank?
PT-141 (Bremelanotide) is a skin, hair & aesthetics that melanocortin receptor pharmacology pt-141 is a synthetic cyclic heptapeptide (ac-nle-cyclo[asp-his-dphe-arg-trp-lys]-oh) that binds the melanocortin receptor family with the…. N-Acetyl-Selank is a cognitive that n-acetyl-selank is the n-terminally acetylated analog of selank, a synthetic heptapeptide (thr-lys-pro-arg-pro-gly-pro) derived from the endogenous immunopeptide tuftsin…. The two differ in mechanism, half-life (~2.7 hours vs Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.), and typical dose range.
Which has the longer half-life, PT-141 (Bremelanotide) or N-Acetyl-Selank?
PT-141 (Bremelanotide) has a half-life of ~2.7 hours. N-Acetyl-Selank has a half-life of Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, PT-141 (Bremelanotide) or N-Acetyl-Selank?
Lowest listed price on BodyHackGuide: PT-141 (Bremelanotide) from $34.99, N-Acetyl-Selank from $79.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack PT-141 (Bremelanotide) and N-Acetyl-Selank?
Stacking depends on mechanism overlap, safety profile, and goals. PT-141 (Bremelanotide) and N-Acetyl-Selank should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.