PT-141 (Bremelanotide) vs Melanotan II
Side-by-side comparison of PT-141 (Bremelanotide) and Melanotan II: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
PT-141 (Bremelanotide)
Melanotan II
PT-141 (Bremelanotide)
PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain — not peripherally on genital tissue — to improve sexual desire, arousal, and responsiveness. It is…
Lowest listed price: $34.99 across 5 listings
Full PT-141 (Bremelanotide) profileMelanotan II
Melanotan-II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) engineered in the late 1980s by researchers at the University of Arizona, most prominently Mac Hadley and…
Lowest listed price: $34.99 across 5 listings
Full Melanotan II profileSide-by-side comparison
| Attribute | PT-141 (Bremelanotide) | Melanotan II |
|---|---|---|
| Category | Skin, Hair & Aesthetics | Skin, Hair & Aesthetics |
| Research Stage | FDA Approved | Preclinical |
| Mechanism of Action | Melanocortin Receptor Pharmacology PT-141 is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-OH) that binds the melanocortin receptor family with the following selectivity profile: | Receptor | Primary Location | PT-141 Activity |… | Melanotan-II works by binding to and activating all four G-protein-coupled melanocortin receptors expressed in mammalian tissue (MC1R, MC3R, MC4R, MC5R - MC2R responds only to ACTH), with particularly high affinity at MC1R, MC3R, and MC4R. Melanocortin… |
| Half-Life | ~2.7 hours | Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours. |
| Typical Dose Range | 500–2,000 mcg (0.5–2 mg) per dose | — |
| Dosing Frequency | As needed, 45 minutes before sexual activity; max once per 24 hours, max 8 doses/month | — |
| Administration | Subcutaneous | — |
| Side Effects | Very Common (10% of users) - Nausea — By far the most common adverse effect, affecting approximately 40% of users in the RECONNECT trials. Usually mild-to-moderate, begins within 30-60 minutes of injection, resolves within 2-4 hours. Can be mitigated with… | The side-effect profile of MT-II is dose-dependent and largely driven by pan-melanocortin receptor activation. Many users experience the acute side effects as more limiting than the tanning benefit. Very Common (50% of users): - Nausea — the single most common… |
| Molecular Weight | 1025.2 Da | ~1024.2 g/mol (average molecular weight; monoisotopic mass ~1023.5 Da). Molecular formula C50H69N15O9 (PubChem CID 92432). |
| Common Vial Sizes | 2mg, 10mg | — |
Price History
5 data points- BM
- Half Nattys
- Ion Peptide
- BHG Labs
Price History
3 data points- Half Nattys
- Ion Peptide
- Disguised Alpha
PT-141 (Bremelanotide): potential benefits
- Sexual desire enhancement
- HSDD treatment
- Erectile dysfunction (central mechanism)
- Non-hormonal approach
Melanotan II: potential benefits
- Tanning without UV
- Appetite suppression
- Sexual arousal
- Photoprotection
- Fat loss
Frequently asked
What's the difference between PT-141 (Bremelanotide) and Melanotan II?
PT-141 (Bremelanotide) is a skin, hair & aesthetics that melanocortin receptor pharmacology pt-141 is a synthetic cyclic heptapeptide (ac-nle-cyclo[asp-his-dphe-arg-trp-lys]-oh) that binds the melanocortin receptor family with the…. Melanotan II is a skin, hair & aesthetics that melanotan-ii works by binding to and activating all four g-protein-coupled melanocortin receptors expressed in mammalian tissue (mc1r, mc3r, mc4r, mc5r - mc2r responds only to…. The two differ in mechanism, half-life (~2.7 hours vs Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours.), and typical dose range.
Which has the longer half-life, PT-141 (Bremelanotide) or Melanotan II?
PT-141 (Bremelanotide) has a half-life of ~2.7 hours. Melanotan II has a half-life of Approximately 30-60 minutes (subcutaneous; limited published human pharmacokinetic data). Peak plasma levels occur ~1-2 hours after injection, and subjective effects typically persist 4-8 hours.. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, PT-141 (Bremelanotide) or Melanotan II?
Lowest listed price on BodyHackGuide: PT-141 (Bremelanotide) from $34.99, Melanotan II from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack PT-141 (Bremelanotide) and Melanotan II?
Stacking depends on mechanism overlap, safety profile, and goals. PT-141 (Bremelanotide) and Melanotan II should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy PT-141 (Bremelanotide) or Melanotan II
Check the vendor trust score. Every supplier we track is rated 0-100 on COA verification, payment transparency, shipping, reviews, and listings: one published, reproducible methodology, applied to every vendor.
Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks, and every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.