PT-141 (Bremelanotide) vs Melanotan II
Independent, side-by-side comparison of PT-141 (Bremelanotide) and Melanotan II: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.
Live price snapshot
PT-141 (Bremelanotide)
Melanotan II
PT-141 (Bremelanotide)
PT-141 (bremelanotide) is a cyclic 7-amino-acid synthetic melanocortin receptor agonist that acts centrally in the brain — not peripherally on genital tissue — to enhance sexual desire, arousal, and responsiveness. It is…
Live lowest price: $29.99 across 7 vendors
Full PT-141 (Bremelanotide) profileMelanotan II
Melanotan-II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (╬▒-MSH) engineered in the late 1980s by researchers at the University of Arizona, most prominently Mac Hadley and…
Live lowest price: $34.99 across 5 vendors
Full Melanotan II profileSide-by-side comparison
| Attribute | PT-141 (Bremelanotide) | Melanotan II |
|---|---|---|
| Category | Skin, Hair & Aesthetics | Skin, Hair & Aesthetics |
| Research Stage | FDA Approved | Preclinical |
| Mechanism of Action | Melanocortin Receptor Pharmacology PT-141 is a synthetic cyclic heptapeptide (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-OH) that binds the melanocortin receptor family with the following selectivity profile: | Receptor | Primary Location | PT-141 Activity |… | Melanotan-II works by binding to and activating all four G-protein-coupled melanocortin receptors expressed in mammalian tissue (MC1R, MC3R, MC4R, MC5R — MC2R responds only to ACTH), with particularly high affinity at MC1R, MC3R, and MC4R. Melanocortin… |
| Half-Life | ~2 hours | — |
| Typical Dose Range | 500–2,000 mcg (0.5–2 mg) per dose | — |
| Dosing Frequency | As needed, 45 minutes before sexual activity; max once per 24 hours, max 8 doses/month | — |
| Administration | Subcutaneous | — |
| Side Effects | Very Common (10% of users) - Nausea — By far the most common adverse effect, affecting approximately 40% of users in the RECONNECT trials. Usually mild-to-moderate, begins within 30-60 minutes of injection, resolves within 2-4 hours. Can be mitigated with… | The side-effect profile of MT-II is dose-dependent and largely driven by pan-melanocortin receptor activation. Many users experience the acute side effects as more limiting than the tanning benefit. Very Common (50% of users): - Nausea — the single most common… |
| Molecular Weight | 1025.2 Da | 1024.19 g/mol |
| Common Vial Sizes | 2mg, 10mg | — |
Price History
5 data points- OF
- Unknown
- Nova Peptides
- VANDL Labs
- Adera
- Ion Peptide
Price History
3 data points- VANDL Labs
- Adera
- Ion Peptide
PT-141 (Bremelanotide) — potential benefits
- Sexual desire enhancement
- HSDD treatment
- Erectile dysfunction (central mechanism)
- Non-hormonal approach
Melanotan II — potential benefits
- Tanning without UV
- Appetite suppression
- Sexual arousal
- Photoprotection
- Fat loss
Frequently asked
What's the difference between PT-141 (Bremelanotide) and Melanotan II?
PT-141 (Bremelanotide) is a skin, hair & aesthetics that melanocortin receptor pharmacology pt-141 is a synthetic cyclic heptapeptide (ac-nle-cyclo[asp-his-dphe-arg-trp-lys]-oh) that binds the melanocortin receptor family with the…. Melanotan II is a skin, hair & aesthetics that melanotan-ii works by binding to and activating all four g-protein-coupled melanocortin receptors expressed in mammalian tissue (mc1r, mc3r, mc4r, mc5r — mc2r responds only to…. The two differ in mechanism, half-life (~2 hours vs not reported), and typical dose range.
Which has the longer half-life, PT-141 (Bremelanotide) or Melanotan II?
PT-141 (Bremelanotide) has a half-life of ~2 hours. Melanotan II has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, PT-141 (Bremelanotide) or Melanotan II?
Current lowest live price on BodyHackGuide: PT-141 (Bremelanotide) from $29.99, Melanotan II from $34.99. Prices are pulled from the vendor listings tracked on BHG and change frequently — see the compare tables on each compound page for the current set of offers.
Can you stack PT-141 (Bremelanotide) and Melanotan II?
Stacking depends on mechanism overlap, safety profile, and goals. PT-141 (Bremelanotide) and Melanotan II should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is an independent research reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks — this never affects the data or pricing shown. See editorial standards and affiliate disclosure.