N-Acetyl-Selank
CognitivePreclinical (the N-acetyl analog has no dedicated studies); parent Selank has limited clinical use in RussiaAlso known as: NASA-Selank, N-Acetyl Selank
N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a tuftsin-derived heptapeptide used intranasally for its reported anxiolytic and nootropic effects. The acetyl group is claimed to improve stability and duration versus standard Selank, though the analog itself is essentially unstudied.
Overview
At A Glance
N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tail added to slow enzymatic breakdown. Because published phar…
Mechanism of Action
N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunopeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro tail added to slow enzymatic breakdown. Because published pharmacology exists only for Selank itself, the mechanisms below are inherited from the parent peptide; the acetyl modification is discussed separately.
Parent Selank mechanisms (preclinical and limited clinical work):
- GABAergic modulation: acts as a subtype-selective positive allosteric modulator of GABA-A receptor binding, proposed to underlie its benzodiazepine-like anxiolytic effect without classic sedation or dependence [PMID:30255741].
- Enkephalin/opioid system: raises the half-life of leu-enkephalin (slows its degradation), and its anxiolytic sensitivity is opioid-dependent, pointing to modulation of the enkephalinergic system [PMID:18454096][PMID:22550852].
- Neurotrophic signaling: normalizes brain-derived neurotrophic factor (BDNF) in the hippocampus and prefrontal cortex in rodent models [PMID:31625062].
- Route-dependent receptor effects: intranasal vs. intraperitoneal dosing shifts the balance between GABA and NMDA receptor binding, consistent with formation of active fragments [PMID:29787664].
The acetyl group: N-terminal acetylation is used (as with N-Acetyl-Semax) to blunt aminopeptidase cleavage of the exposed N-terminus, which vendors and users claim extends stability and duration of action. This specific claim has not been tested for Selank in any published study, so treat it as a plausible chemistry-based rationale rather than a demonstrated fact.
Overview
N-Acetyl-Selank is the N-terminally acetylated analog of Selank, a tuftsin-derived heptapeptide used intranasally for its reported anxiolytic and nootropic effects. The acetyl group is claimed to improve stability and duration versus standard Selank, though the analog itself is essentially unstudied. Research use only (RUO).
What to Expect
- •Subtle, non-sedating calm rather than a strong acute effect; parent Selank is described as a 'mild' anxiolytic [PMID:30255741].
- •Community users of the acetyl analog report calm focus and reduced stress reactivity, often within 15-40 minutes of an intranasal dose (anecdotal).
- •Any claimed longer duration from acetylation is not documented in published studies - individual response varies.
- •Nootropic/attention benefits, where reported, tend to be modest and build over a multi-day course rather than from a single dose [PMID:31625062].
Individual responses vary. Timeline based on commonly reported research observations.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
~793.9 g/mol (theoretical: Selank ~751.9 g/mol + N-terminal acetyl, ~+42). Approximate molecular formula C35H59N11O10.
Amino Acid Sequence
Dosing & Protocols
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Research
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Interactions
Interaction Matrix
Contraindications
Pregnancy and breastfeeding (untested). Known hypersensitivity to the peptide. Use caution - ideally under professional guidance - if combining with benzodiazepines, other GABAergic agents, opioids, or alcohol, because parent Selank modulates GABA/enkephalin signaling and potentiated diazepam in animal models [PMID:28280289][PMID:22550852]. Not a substitute for prescribed treatment of an anxiety disorder. Research use only; not for human consumption where prohibited.
Research Disclaimer
This interaction data is compiled from published research and community reports. It may not be exhaustive. Always consult a healthcare professional before combining compounds.
$79.99
$2.6663
1
2
vial, nasal
Tracking since Sep 5, 2026 · 2 data points
Vendors Selling N-Acetyl-Selank
How we score these vendors
Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.
Related Compounds
View AllN-Acetyl-Semax
CognitiveDuplicate entry - see NA-SemaxThis is a duplicate/alias entry.
Noopept + Choline Chloride Blend
CognitiveBlend has no clinical trials; component evidence ranges from preclinical (Noopept) to small human RCTs (choline sources).A community nootropic stack pairing Noopept, a potent racetam-family dipeptide, with a choline source (commonly alpha-GPC, CDP-choline/citicoline, or choline bitartrate).
Side-by-Side Comparisons
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Protocols, calculator & safety for N-Acetyl-Selank
Research Score
0 PubMed results
Quality Indicators
Data Completeness
75%Quick Facts
Half-Life
Not established for the N-acetyl analog. Parent Selank has a very short plasma half-life (on the order of minutes, as expected for a small peptide) but produces behavioral effects lasting hours, attributed to active fragments and downstream enkephalin/GABA modulation. N-acetylation is claimed to slow N-terminal degradation and extend duration, but this is unquantified in published literature.
Molecular Weight
~793.9 g/mol (theoretical: Selank ~751.9 g/mol + N-terminal acetyl, ~+42). Approximate molecular formula C35H59N11O10.
Trial Phase
Preclinical (the N-acetyl analog has no dedicated studies); parent Selank has limited clinical use in Russia
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is N-Acetyl-Selank and how is it different from regular Selank?
It's Selank (the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro) with an acetyl group added to the N-terminus. The modification is meant to slow enzymatic breakdown of the peptide's front end - the same trick used for N-Acetyl-Semax - and is claimed to give longer, more stable activity. That claim hasn't been confirmed in any published study on Selank.
Does N-Acetyl-Selank actually work better than Selank?
There's no head-to-head data. All of the human and animal evidence is for plain Selank; the acetylated version has no dedicated trials. Any 'works better / lasts longer' claims are theoretical or anecdotal, so treat them cautiously.
How is it taken?
Intranasally, as a nasal spray - it is not injected. Community ranges run roughly 100-900 mcg/day, usually 1-2 sprays, often in 2-4 week courses. There is no clinically established dose for the analog. Research use only.
Is it safe?
Parent Selank was well tolerated in short Russian trials with no serious side effects reported [PMID:18454096], but the acetyl analog has no safety studies at all. Reported issues are mild (nasal irritation, transient fatigue, headache). Long-term safety is unknown.
Can I combine it with other supplements or medications?
Be cautious with benzodiazepines, other GABAergic compounds, opioids, and alcohol - parent Selank modulates GABA and enkephalin signaling and potentiated diazepam in animal studies [PMID:28280289]. Talk to a professional before combining, and don't use it as a replacement for prescribed anxiety treatment.
Is N-Acetyl-Selank approved or legal?
It is not approved by the FDA or EMA. Even standard Selank is a registered medicine only in Russia. N-Acetyl-Selank is sold as a research chemical and is intended for research use only.
Research Tools
Related Compounds
View AllN-Acetyl-Semax
CognitiveDuplicate entry - see NA-SemaxThis is a duplicate/alias entry.
Noopept + Choline Chloride Blend
CognitiveBlend has no clinical trials; component evidence ranges from preclinical (Noopept) to small human RCTs (choline sources).A community nootropic stack pairing Noopept, a potent racetam-family dipeptide, with a choline source (commonly alpha-GPC, CDP-choline/citicoline, or choline bitartrate).
Side-by-Side Comparisons
All ComparisonsCompare N-Acetyl-Selank head-to-head: mechanism, half-life, dosing, safety, and vendor prices.
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