Urolithin A vs NMN
Independent, side-by-side comparison of Urolithin A and NMN: mechanism, half-life, dose range, safety profile, and live vendor pricing. Updated continuously as new research and listings land.
Live price snapshot
Urolithin A
NMN
Urolithin A
Urolithin A (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one; trade name Mitopure from Timeline Nutrition, formerly Amazentis) is a gut-microbiome-derived metabolite of dietary ellagitannins — polyphenolic compounds found in…
Full Urolithin A profileNMN
Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide derived from ribose and nicotinamide, serving as the direct biosynthetic precursor to nicotinamide adenine dinucleotide (NAD+) via a single enzymatic…
Full NMN profileSide-by-side comparison
| Attribute | Urolithin A | NMN |
|---|---|---|
| Category | Mitochondrial Support | Longevity |
| Research Stage | Preclinical | Preclinical |
| Mechanism of Action | Urolithin A's mechanism of action centers on induction of mitophagy — the selective autophagic degradation of damaged mitochondria — with additional secondary effects on mitochondrial biogenesis, cellular stress resistance, and inflammatory signaling.… | NMN functions as a direct precursor to NAD+ (nicotinamide adenine dinucleotide) through the NAD+ salvage pathway. The conversion requires a single enzymatic step catalyzed by NMNAT (nicotinamide mononucleotide adenylyltransferase), which adenylates NMN using… |
| Half-Life | — | — |
| Typical Dose Range | — | — |
| Dosing Frequency | — | — |
| Administration | — | — |
| Side Effects | Urolithin A has an exceptionally favorable safety profile among longevity-relevant interventions, reflecting both its status as a naturally occurring gut-microbiome metabolite found in human bloodstream from ellagitannin-containing foods and deliberate… | NMN has a favorable short-term safety profile across tested human doses (100-1200 mg/day for up to 12 weeks in available studies). Across multiple clinical trials, no serious NMN-attributable adverse events have been reported, and commonly-reported side… |
| Molecular Weight | — | — |
| Common Vial Sizes | — | — |
Frequently asked
What's the difference between Urolithin A and NMN?
Urolithin A is a mitochondrial support that urolithin a's mechanism of action centers on induction of mitophagy — the selective autophagic degradation of damaged mitochondria — with additional secondary effects on…. NMN is a longevity that nmn functions as a direct precursor to nad+ (nicotinamide adenine dinucleotide) through the nad+ salvage pathway. the conversion requires a single enzymatic step catalyzed by nmnat…. The two differ in mechanism, half-life (not reported vs not reported), and typical dose range.
Which has the longer half-life, Urolithin A or NMN?
Urolithin A has a half-life of not reported. NMN has a half-life of not reported. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Can you stack Urolithin A and NMN?
Stacking depends on mechanism overlap, safety profile, and goals. Urolithin A and NMN should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
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Research use only. BodyHackGuide is an independent research reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. We earn an affiliate commission on some outbound clicks — this never affects the data or pricing shown. See editorial standards and affiliate disclosure.