NAD+ vs MOTS-c
Side-by-side comparison of NAD+ and MOTS-c: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
NAD+
MOTS-c
NAD+
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.…
Lowest listed price: $25.00 across 11 listings
Full NAD+ profileMOTS-c
MOTS-c (Mitochondrial ORF of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide — a member of a recently discovered class of small peptides encoded in mitochondrial DNA rather than nuclear DNA. It…
Lowest listed price: $44.99 across 9 listings
Full MOTS-c profileSide-by-side comparison
| Attribute | NAD+ | MOTS-c |
|---|---|---|
| Category | Longevity | Longevity & Cellular Health |
| Research Stage | Phase II | Preclinical |
| Mechanism of Action | Redox Cofactor Function NAD+ serves as the primary electron acceptor in catabolic reactions (glycolysis, TCA cycle, fatty acid oxidation), cycling between its oxidized (NAD+) and reduced (NADH) forms. This fundamental energy metabolism role means every cell… | A New Class of Signaling Molecule MOTS-c belongs to the mitochondrial-derived peptides (MDPs) - a class of small peptides encoded within mitochondrial DNA open reading frames that were historically thought to encode only ribosomal RNAs. The known MDPs include:… |
| Half-Life | Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent | ~4–6 hours |
| Typical Dose Range | Oral precursors: NR 300-2,000 mg/day, NMN 250-900 mg/day, NAM 500-1,500 mg/day; IV NAD+ 500-1,500 mg per session. | 5,000–10,000 mcg (5–10 mg) per injection |
| Dosing Frequency | Oral precursors once daily (higher doses split AM/midday); IV NAD+ weekly-to-monthly at clinics. | 2-3 times per week |
| Administration | Oral (precursors), Intravenous, Intramuscular, Subcutaneous | Subcutaneous, Intramuscular |
| Side Effects | Nicotinamide Riboside (NR) NR has the best-characterized safety profile of the NAD+ precursors. Across published RCTs at 1,000-2,000 mg/day for up to 12 weeks, adverse effects have been mild and uncommon: - Gastrointestinal upset (5-10% of users) - Mild… | Reported Effects (limited human data) - Injection site reactions — Mild erythema, transient itching at SC injection site. Site rotation minimizes. Probably the single most reported issue. - Transient fatigue — Some users report mild fatigue in the first week… |
| Molecular Weight | 663.4 g/mol (NAD+); NR 255.3 g/mol; NMN 334.2 g/mol; NAM 122.1 g/mol | 2174 Da |
| Common Vial Sizes | 100mg, 250mg, 500mg | 5mg, 10mg |
Price History
4 data points- OF
- BM
- Half Nattys
- Ion Peptide
- BHG Labs
Price History
5 data points- OF
- BM
- Half Nattys
- Ion Peptide
- Disguised Alpha
- BHG Labs
NAD+: potential benefits
- Restores age-associated NAD+ decline — 50% loss between young and older adulthood
- Increases peripheral blood NAD+ by up to 142% at 1,000 mg NR daily (Elhassan 2019)
- Supports sirtuin-mediated gene regulation and PARP-mediated DNA repair
- Improves muscle insulin sensitivity in prediabetic postmenopausal women (Yoshino 2021)
- Increases aerobic performance in amateur runners at 300-600 mg NMN (Liao 2021)
- Reduces inflammatory cytokines (IL-6, TNF-alpha) in middle-aged/elderly (Martens, Elhassan)
- Brain NAD+ elevation demonstrated in Parkinson trial (Brakedal 2022)
- Excellent safety profile at evidence-supported doses (500-2000 mg/day NR)
MOTS-c: potential benefits
- Insulin sensitivity
- Exercise mimicry
- Metabolic health
- Anti-aging
- Fat oxidation
- Longevity
Frequently asked
What's the difference between NAD+ and MOTS-c?
NAD+ is a longevity that redox cofactor function nad+ serves as the primary electron acceptor in catabolic reactions (glycolysis, tca cycle, fatty acid oxidation), cycling between its oxidized (nad+) and…. MOTS-c is a longevity & cellular health that a new class of signaling molecule mots-c belongs to the mitochondrial-derived peptides (mdps) - a class of small peptides encoded within mitochondrial dna open reading frames that…. The two differ in mechanism, half-life (Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent vs ~4–6 hours), and typical dose range.
Which has the longer half-life, NAD+ or MOTS-c?
NAD+ has a half-life of Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent. MOTS-c has a half-life of ~4–6 hours. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, NAD+ or MOTS-c?
Lowest listed price on BodyHackGuide: NAD+ from $25.00, MOTS-c from $44.99. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack NAD+ and MOTS-c?
Stacking depends on mechanism overlap, safety profile, and goals. NAD+ and MOTS-c should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
Listings from the vendors we track. Prices change often, so check the vendor before you buy.
Before you buy NAD+ or MOTS-c
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.