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    PDRN

    Skin & HairPhase 4

    Also known as: Polydeoxyribonucleotide, Placentex, Nucleofill, Salmon DNA, Nucleotide polymer

    PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa.

    Half-Life: Short (oligonucleotides degraded rapidly; tissue effects persist longer)Route: Subcutaneous, Intradermal, TopicalMW: No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule [PMID:19860658].
    Last reviewed:
    Skin & Hair
    Category
    Phase 4
    Research Stage

    Overview

    Best Price Available

    Ion Peptide logo

    Ion Peptide

    $34.95

    1 jar · topical

    At A Glance

    Mechanism

    PDRN exerts effects through two primary mechanisms: (1) Adenosine A2A receptor agonism — PDRN is hydrolyzed to deoxyadenosine fragments that activate A2A receptors on fibroblasts, endothelial cells, and macrophages. A2A activation stimulates VEGF production (angiogenesis), collag…

    Half-Life
    Short (oligonucleotides degraded rapidly; tissue effects persist longer)
    Dosing
    weekly
    Dose Range
    0mcg
    Routes
    SubcutaneousIntradermalTopical
    Potential Benefits
    Wound healing acceleration - enhanced angiogenesis, fibroblast proliferation, and collagen synthesisDiabetic foot ulcer healing - supported by a randomized, double-blind, placebo-controlled trial (complete healing 37.3% vs 18.9% for placebo) [PMID:24483158]Skin rejuvenation - clinical studies suggest improved texture and elasticity, though a 2024 systematic review found the aesthetic evidence base inconsistent [PMID:39198280]Hair loss - preliminary evidence only; a small uncontrolled study in female pattern hair loss reported improved hair count and thickness (not established for androgenetic alopecia) [PMID:25524027]Anti-inflammatory tissue remodeling - reduction of pro-inflammatory cytokines via adenosine A2A receptor signalingAesthetic skin treatments - widely used in South Korean and European clinical practice
    Safety Notes
    Common
    Mild injection site bruising and swellingTransient rednessWell tolerated in aesthetic clinical literature
    Serious
    Allergic reaction risk (salmon-derived product)No serious systemic adverse events in published aesthetic medicine RCTs

    Overview

    PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications.

    Chemical Information

    IUPAC Name

    Not yet available

    CAS Number

    Not yet available

    Molecular Formula

    Not yet available

    Molecular Mass

    No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule [PMID:19860658].

    Dosing & Protocols

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    Research

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    Interactions

    Interaction and contraindication data is being compiled for PDRN. Check back soon.

    General Safety Note

    Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.

    Best Price

    $34.95

    Best $/mg

    —

    Vendors

    1

    Listings

    1

    topical

    Form
    Sort
    Vendor Product Form Qty Price $/mg Coupon
    Ion Peptide logo
    Ion Peptide
    70
    🇺🇸US🌍International
    		 PDRN Pink Cream topical 1 jar● In Stock $34.95BEST — —

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    Current low
    $34.95
    as of Apr 22, 2026
    7-day low
    —
    no 7d data yet
    30-day low
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    no 30d data yet
    30-day change
    —
    baseline building

    Tracking since Apr 22, 2026 · 1 data point

    Vendors Selling PDRN

    How we score these vendors

    Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.

    View Scorecard

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    Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction.

    t½ Short (topical application, no systemic absorption at cosmetic doses) 0
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    AHK-Cu

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    t½ Unknown (topical half-life, follicular retention not well characterized) 0
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    Melanotan 2

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    t½ ~1–2 hours 100-1,000 mcg per injection
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    Minoxidil

    Skin & HairFDA-Approved

    Minoxidil is an FDA-approved treatment for pattern hair loss.

    t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically.
    PreclinicalView Profile

    Snap-8

    Skin & HairPreclinical

    Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox).

    t½ Not characterized (topical peptide) 0
    PreclinicalView Profile

    View Full Dosage Guide →

    Protocols, calculator & safety for PDRN

    Best Price

    Ion Peptide logo

    Ion Peptide

    $34.95

    1 vendors · 1 listings

    Research Score

    45

    0 PubMed studies

    Quality Indicators

    Data Completeness

    63%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Studies
    Interactions
    Vendor Listings

    Quick Facts

    Half-Life

    Short (oligonucleotides degraded rapidly; tissue effects persist longer)

    Molecular Weight

    No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule [PMID:19860658].

    Administration

    Subcutaneous, Intradermal, Topical

    Trial Phase

    Phase 4

    Safety Profile

    Common Side Effects

    • • Mild injection site bruising and swelling
    • • Transient redness
    • • Well tolerated in aesthetic clinical literature

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is PDRN used for in research?

    PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications.

    What forms does PDRN come in?

    PDRN is available in topical form.

    How much does PDRN cost?

    Prices start at $34.95 across 1 verified vendor.

    How do I compare PDRN vendors?

    Compare prices, payment methods, shipping, and COA scores across 1 vendor.

    Research Tools

    Related Compounds

    View All

    Acetyl Hexapeptide-8

    Skin & HairMarketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug.

    Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction.

    t½ Short (topical application, no systemic absorption at cosmetic doses) 0
    PreclinicalView Profile

    AHK-Cu

    Skin & HairPreclinical

    AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper).

    t½ Unknown (topical half-life, follicular retention not well characterized) 0
    PreclinicalView Profile

    Melanotan 2

    Skin & HairDiscontinued (early clinical)

    A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression..

    t½ ~1–2 hours 100-1,000 mcg per injection
    PreclinicalView Profile

    Minoxidil

    Skin & HairFDA-Approved

    Minoxidil is an FDA-approved treatment for pattern hair loss.

    t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically.
    PreclinicalView Profile

    Snap-8

    Skin & HairPreclinical

    Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox).

    t½ Not characterized (topical peptide) 0
    PreclinicalView Profile

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