PDRN
Skin & HairPhase 4Also known as: Polydeoxyribonucleotide, Placentex, Nucleofill, Salmon DNA, Nucleotide polymer
PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa.
Overview
At A Glance
PDRN exerts effects through two primary mechanisms: (1) Adenosine A2A receptor agonism — PDRN is hydrolyzed to deoxyadenosine fragments that activate A2A receptors on fibroblasts, endothelial cells, and macrophages. A2A activation stimulates VEGF production (angiogenesis), collag…
Overview
PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
Not yet available
Chemical data is being compiled for this compound.
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for PDRN. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
$34.95
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1
1
topical
Tracking since Apr 22, 2026 · 1 data point
Vendors Selling PDRN
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Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.
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Protocols, calculator & safety for PDRN
Related Articles
All PostsResearch Score
0 PubMed studies
Quality Indicators
Data Completeness
63%Quick Facts
Half-Life
Short (oligonucleotides degraded rapidly; tissue effects persist longer)
Administration
Subcutaneous, Intradermal, Topical
Trial Phase
Phase 4
Safety Profile
Common Side Effects
- • Mild injection site bruising and swelling
- • Transient redness
- • Well tolerated in aesthetic clinical literature
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is PDRN used for in research?
PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications.
What forms does PDRN come in?
PDRN is available in topical form.
How much does PDRN cost?
Prices start at $34.95 across 1 verified vendor.
How do I compare PDRN vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View AllAcetyl Hexapeptide-8
Skin & HairPreclinicalAcetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction.
AHK-Cu
Skin & HairPreclinicalAHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper).
Melanotan 2
Skin & HairPhase IIA synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression..
Minoxidil
Skin & HairPreclinicalFDA-approved topical vasodilator used for hair regrowth.
Snap-8
Skin & HairPreclinicalSnap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox).
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