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PDRN

Name: PDRN
Brand: Research Compound
Availability: InStock

Skin & HairPhase 4

Also known as: Polydeoxyribonucleotide, Placentex, Nucleofill, Salmon DNA, Nucleotide polymer

Lowest price

$34.951 jar

at Ion Peptide

Buy at Ion Peptide

Half-life: Short (oligonucleotides degraded rapidlyRoute: Subcutaneous, Intradermal, TopicalMW: No single value - PDRN is a heterogeneous mixture of deoxyr…

Last reviewed: Oct 19, 2026

Overview

At A Glance

Mechanism

PDRN exerts effects through two primary mechanisms: (1) Adenosine A2A receptor agonism — PDRN is hydrolyzed to deoxyadenosine fragments that activate A2A receptors on fibroblasts, endothelial cells, and macrophages. A2A activation stimulates VEGF production (angiogenesis), collag…

Half-Life

Short (oligonucleotides degraded rapidly; tissue effects persist longer)

Dosing

weekly

Routes

SubcutaneousIntradermalTopical

Potential Benefits

Wound healing acceleration - enhanced angiogenesis, fibroblast proliferation, and collagen synthesisDiabetic foot ulcer healing - supported by a randomized, double-blind, placebo-controlled trial (complete healing 37.3% vs 18.9% for placebo) [PMID:24483158]Skin rejuvenation - clinical studies suggest improved texture and elasticity, though a 2024 systematic review found the aesthetic evidence base inconsistent [PMID:39198280]Hair loss - preliminary evidence only; a small uncontrolled study in female pattern hair loss reported improved hair count and thickness (not established for androgenetic alopecia) [PMID:25524027]Anti-inflammatory tissue remodeling - reduction of pro-inflammatory cytokines via adenosine A2A receptor signalingAesthetic skin treatments - widely used in South Korean and European clinical practice

Safety Notes

Common

Mild injection site bruising and swellingTransient rednessWell tolerated in aesthetic clinical literature

Serious

Allergic reaction risk (salmon-derived product)No serious systemic adverse events in published aesthetic medicine RCTs

Overview

PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation. It consists of polynucleotide chains with molecular weights ranging from 50 to 1500 kDa. PDRN is widely used in Asian aesthetic medicine (particularly South Korea) for skin rejuvenation, wound healing, and hair loss treatment. It is available as an injectable sterile solution (Placentex Integro) licensed in several countries, as well as topical formulations and cosmetic creams. PDRN's mechanism centers on adenosine A2A receptor activation, stimulating collagen synthesis, cellular proliferation, and anti-inflammatory pathways. It is one of the few compounds in this catalog with a substantial published clinical (Phase 4) evidence base in aesthetic applications.

Chemical Information

IUPAC Name

Not yet available

CAS Number

Not yet available

Molecular Formula

Not yet available

Molecular Mass

No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule [PMID:19860658].

Dosing & Protocols

Dosing Summary

Route

Subcutaneous, Intradermal, Topical

Frequency

weekly

Research-use-only compound; not an FDA-approved drug in the US. Where PDRN is used clinically or aesthetically abroad (for example Placentex by Mastelli), the injectable is supplied as a 3 mL ampoule containing 5.625 mg (about 1.875 mg/mL). Published regimens give roughly one ampoule per session by intramuscular and/or perilesional or intradermal injection - several times per week in wound-healing protocols, or about weekly for aesthetic skin courses of roughly 4 to 8 sessions. Topical PDRN cosmetic serums are also marketed. Concentration, volume, and schedule vary by product and indication; these figures summarize the published literature and are not a dosing recommendation.

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Research

PubMed Results

Key Research Findings

PDRN has genuine human clinical data, strongest for wound healing. In a randomized, double-blind, placebo-controlled trial of 216 patients with Wagner grade 1-2 diabetic foot ulcers, PDRN (intramuscular plus perilesional injection over 8 weeks) achieved complete healing in 37.3% of patients versus 18.9% with placebo (P=0.0027) and shortened median time to closure to 30 vs 49 days [PMID:24483158]. A separate randomized controlled trial in diabetic foot ulcers found PDRN improved peripheral tissue oxygenation and angiogenesis versus saline [PMID:29076318]. Systematic and narrative reviews of in vitro, animal, and clinical studies conclude that PDRN promotes tissue repair, angiogenesis, and collagen production with a favorable safety profile, acting through adenosine A2A receptor activation and the nucleotide salvage pathway [PMID:32757710][PMID:34832885][PMID:27791262]; PDRN is characterized as a trout/salmon-derived mixture of deoxyribonucleotide polymers (chains ~50-2000 bp) that induces VEGF and angiogenesis [PMID:19860658]. Evidence for aesthetic skin rejuvenation exists but is of variable quality - a 2024 PRISMA systematic review of regenerative aesthetics judged the overall evidence base inconsistent and called for more rigorous trials [PMID:39198280]. Hair-loss data are preliminary: a small uncontrolled study in female pattern hair loss reported improved hair count and thickness after perifollicular PDRN (with or without PRP) injections [PMID:25524027]. Most clinical use occurs abroad (Italy, South Korea); PDRN is not FDA-approved in the US and is offered domestically for research use only.

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Interactions

Interaction and contraindication data is being compiled for PDRN. Check back soon.

General Safety Note

Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.

Best Price

$34.95

Best $/mg

—

Vendors

Listings

topical

Form

Sort

Vendor	Product	Form	Qty	Price	$/mg	Coupon
Ion Peptide 70 🇺🇸US🌍International	PDRN Pink Cream	topical	1 jar● In Stock	$34.95BEST	—	—

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Current low

$34.95

current listings

7-day low

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Tracking since Apr 22, 2026 · 1 data point

Vendors Selling PDRN

Ion Peptide

4.5

1 listing · from $34.95

How we score these vendors

Every supplier above is graded 0 to 100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.

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Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction.

t½ Short (topical application, no systemic absorption at cosmetic doses)

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t½ Unknown (topical half-life, follicular retention not well characterized)

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t½ ~1–2 hours 100-1,000 mcg per injection

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Minoxidil

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t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically.

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View Full Dosage Guide →

Protocols, calculator & safety for PDRN

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Ion Peptide Review 2026: BPC-157, GLP-1s, Buccal Strips & Bioregulators

A complete look at Ion Peptide (ionpeptide.com), whose 92 products span research peptides, GLP-1 agonists, NAD+/B12/glutathione buccal strips, copper peptide topicals, Khavinson bioregulators, and PDRN. We cover pricing, testing, shipping, what they stock that others don't, and how they compare to other vendors on BodyHackGuide.

4/21/2026

Lowest Price

Ion Peptide

$34.95

1 vendor · 1 listing

Research Score

0 PubMed results

Quality Indicators

Data Completeness

63%

Description

Mechanism of Action

Chemical Data

Dosing Protocols

Safety Profile

PubMed Results

Interactions

Vendor Listings

Quick Facts

Half-Life

Short (oligonucleotides degraded rapidly; tissue effects persist longer)

Molecular Weight

No single value - PDRN is a heterogeneous mixture of deoxyribonucleotide polymers (chain lengths ~50-2000 bp, roughly 50-1500 kDa) rather than one defined molecule [PMID:19860658].

Administration

Subcutaneous, Intradermal, Topical

Trial Phase

Phase 4

Safety Profile

Common Side Effects

• Mild injection site bruising and swelling
• Transient redness
• Well tolerated in aesthetic clinical literature

Research Disclaimer

This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

Frequently Asked Questions

What is PDRN used for in research?

What forms does PDRN come in?

PDRN is available in topical form.

How do I compare PDRN vendors?

Compare prices, payment methods, shipping, and COA scores across 1 vendor.

How many vendors sell PDRN, and what does it cost per mg?

1 of the vendors BodyHackGuide tracks list PDRN (1 listing). The lowest listed price BodyHackGuide has recorded for PDRN is $34.95. No PDRN listing recorded as in stock carries a milligram count, so BodyHackGuide states no price per milligram for PDRN.

Which vendors have third-party COAs for PDRN on file at BodyHackGuide?

BodyHackGuide holds no third-party certificate records for PDRN. Each vendor page on BodyHackGuide shows how many certificate records BodyHackGuide holds for that vendor.