Skip to content

    Research Use Only

    This site is an independent educational resource for research compounds. We do not sell, distribute, or endorse human consumption of any compound. By entering, you confirm you are 21 years of age or older and agree to our Terms & Privacy Policy.

    100K+ researchers trust BodyHackGuide — Join r/BodyHackGuide
    Ion Peptide logo

    Best price right now

    $0.13/mg· $129.00 for 1000mg at Ion Peptide

    Acetyl Hexapeptide-8

    Skin & HairMarketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug.

    Also known as: Argireline, Acetyl Hexapeptide-3, SNAP-6, Botox peptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2

    Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide.

    Half-Life: Short (topical application, no systemic absorption at cosmetic doses)Route: TopicalMW: 888.99 g/mol (average); molecular formula C34H60N14O12S
    Last reviewed:
    Skin & Hair
    Category
    Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug.
    Research Stage

    Overview

    Best Price Available

    Ion Peptide logo

    Ion Peptide

    $129.00

    1g · powder

    At A Glance

    Mechanism

    Acetyl Hexapeptide-8 (Argireline) is patterned after the N-terminal domain of SNAP-25 and behaves as a competitive mimic of that protein during SNARE complex assembly. The SNARE complex (SNAP-25 + Syntaxin-1 + VAMP/synaptobrevin) is required for synaptic-vesicle docking and fusio…

    Half-Life
    Short (topical application, no systemic absorption at cosmetic doses)
    Dosing
    twice daily
    Dose Range
    0mcg
    Routes
    Topical
    Potential Benefits
    Targets dynamic expression wrinkles - forehead, glabellar, and periorbital (crow's feet) linesProposed to reduce facial neuromuscular signaling by destabilizing the ternary SNARE complex (acts as a SNAP-25 N-terminal mimic)A randomized, placebo-controlled human study reported ~49% subjective improvement in periorbital wrinkles vs 0% for placebo over 4 weeks (small evidence base) [PMID: 23417317]Marketed as a topical 'Botox alternative' - reversible mechanism, not a neurotoxin, with no botulinum-type systemic riskSupplied as a raw cosmetic-compounding powder for research/formulation use (verify purity via HPLC COA)Commonly combined with related peptides (e.g., Acetyl Octapeptide-3 / Snap-8) in anti-wrinkle formulations
    Safety Notes
    Common
    Well tolerated in clinical cosmetic literatureMild transient erythema at high concentrations
    Serious
    No systemic adverse events at topical cosmetic dosesNot for injection use

    Overview

    Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.

    Chemical Information

    IUPAC Name

    Not yet available

    CAS Number

    Not yet available

    Molecular Formula

    Not yet available

    Molecular Mass

    888.99 g/mol

    Amino Acid Sequence

    Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 (Ac-EEMQRR-NH2); N-terminally acetylated, C-terminally amidated synthetic hexapeptide patterned after the N-terminal domain of SNAP-25

    Dosing & Protocols

    Unlock Dosing Protocols

    Free account gets you:

    • View beginner, intermediate & advanced protocols
    • See weight-based dosing calculations
    • Access cycle length & frequency data

    2,800+ researchers already in

    Research

    Unlock Research Data

    Free account gets you:

    • Browse PubMed study summaries
    • See clinical trial phases & results
    • Access mechanism of action details

    2,800+ researchers already in

    Interactions

    Interaction and contraindication data is being compiled for Acetyl Hexapeptide-8. Check back soon.

    General Safety Note

    Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.

    Best Price

    $129.00

    Best $/mg

    $0.1290

    Vendors

    1

    Listings

    1

    powder

    Form
    Sort
    Vendor Product Form Qty Price $/mg Coupon
    Ion Peptide logo
    Ion Peptide
    70
    🇺🇸US🌍International
    		 Acetyl Hexapeptide-8 Raw 1g powder 1g● In Stock $129.00BEST $0.129 —

    Get Acetyl Hexapeptide-8 Price Drop Alerts

    Set a target price and we'll notify you when any vendor drops below it. Current lowest: $129.00

    Sign in to leave a review

    Reviews on BodyHackGuide are tied to verified user accounts and moderated before publishing. Sign in (free, no spam) to share your experience with Acetyl Hexapeptide-8.

    Current low
    $129.00
    as of Apr 22, 2026
    7-day low
    —
    no 7d data yet
    30-day low
    —
    no 30d data yet
    30-day change
    —
    baseline building

    Tracking since Apr 22, 2026 · 1 data point

    Vendors Selling Acetyl Hexapeptide-8

    How we score these vendors

    Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.

    View Scorecard

    Related Compounds

    View All

    AHK-Cu

    Skin & HairPreclinical

    AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper).

    t½ Unknown (topical half-life, follicular retention not well characterized) 0
    PreclinicalView Profile

    Melanotan 2

    Skin & HairDiscontinued (early clinical)

    A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression..

    t½ ~1–2 hours 100-1,000 mcg per injection
    PreclinicalView Profile

    Minoxidil

    Skin & HairFDA-Approved

    Minoxidil is an FDA-approved treatment for pattern hair loss.

    t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically.
    PreclinicalView Profile

    PDRN

    Skin & HairPhase 4

    PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation.

    t½ Short (oligonucleotides degraded rapidly; tissue effects persist longer) 0
    PreclinicalView Profile

    Snap-8

    Skin & HairPreclinical

    Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox).

    t½ Not characterized (topical peptide) 0
    PreclinicalView Profile

    View Full Dosage Guide →

    Protocols, calculator & safety for Acetyl Hexapeptide-8

    Best Price

    Ion Peptide logo

    Ion Peptide

    $129.00

    1 vendors · 1 listings

    Research Score

    45

    0 PubMed studies

    Quality Indicators

    Data Completeness

    63%
    Description
    Mechanism of Action
    Chemical Data
    Dosing Protocols
    Safety Profile
    PubMed Studies
    Interactions
    Vendor Listings

    Quick Facts

    Half-Life

    Short (topical application, no systemic absorption at cosmetic doses)

    Molecular Weight

    888.99 g/mol

    Administration

    Topical

    Trial Phase

    Marketed topical cosmetic ingredient (INCI: Acetyl Hexapeptide-8 / Argireline). Supported by small human anti-wrinkle studies, including one randomized, placebo-controlled trial; no systemic or injectable clinical development. Not an FDA-approved drug.

    Safety Profile

    Common Side Effects

    • • Well tolerated in clinical cosmetic literature
    • • Mild transient erythema at high concentrations

    Research Disclaimer

    This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.

    Frequently Asked Questions

    What is Acetyl Hexapeptide-8 used for in research?

    Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.

    What forms does Acetyl Hexapeptide-8 come in?

    Acetyl Hexapeptide-8 is available in powder form.

    How much does Acetyl Hexapeptide-8 cost?

    Prices start at $129.00 across 1 verified vendor.

    How do I compare Acetyl Hexapeptide-8 vendors?

    Compare prices, payment methods, shipping, and COA scores across 1 vendor.

    Research Tools

    Related Compounds

    View All

    AHK-Cu

    Skin & HairPreclinical

    AHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper).

    t½ Unknown (topical half-life, follicular retention not well characterized) 0
    PreclinicalView Profile

    Melanotan 2

    Skin & HairDiscontinued (early clinical)

    A synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression..

    t½ ~1–2 hours 100-1,000 mcg per injection
    PreclinicalView Profile

    Minoxidil

    Skin & HairFDA-Approved

    Minoxidil is an FDA-approved treatment for pattern hair loss.

    t½ Oral minoxidil plasma half-life is approximately 3-4 hours; the hair-growth (pharmacodynamic) effect is independent of plasma level and depends on ongoing daily use. Oral low-dose minoxidil (off-label): 625-5000 mcg/day (0.625-5 mg). Topical minoxidil is dosed by concentration (2% or 5%), not by mcg -- roughly 10-20 mg of minoxidil is delivered per topical application, with only ~1.4% absorbed systemically.
    PreclinicalView Profile

    PDRN

    Skin & HairPhase 4

    PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation.

    t½ Short (oligonucleotides degraded rapidly; tissue effects persist longer) 0
    PreclinicalView Profile

    Snap-8

    Skin & HairPreclinical

    Snap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox).

    t½ Not characterized (topical peptide) 0
    PreclinicalView Profile

    Free 2026 Peptide Cheat Sheet — 50 pages, PDF

    Reconstitution math, concentration charts, half-lives, and vendor trust tiers. The reference we wish we had on day one.

    Download Free

    Need bloodwork before starting?

    Full hormone + metabolic panels from Anabolic Insights. Code CHONCH for first-order discount.