Acetyl Hexapeptide-8
Skin & HairPreclinicalAlso known as: Argireline, Acetyl Hexapeptide-3, SNAP-6, Botox peptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide.
Overview
At A Glance
Acetyl Hexapeptide-8 inhibits SNARE complex assembly by competing with endogenous SNAP-25 for binding at the neuromuscular junction. The SNARE complex (SNAP-25 + Syntaxin-1 + VAMP) is required for synaptic vesicle fusion and acetylcholine release from motor neurons. Competitive i…
Overview
Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.
Chemical Information
IUPAC Name
Not yet available
CAS Number
Not yet available
Molecular Formula
Not yet available
Molecular Mass
Not yet available
Chemical data is being compiled for this compound.
Dosing & Protocols
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Research
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Interactions
Interaction and contraindication data is being compiled for Acetyl Hexapeptide-8. Check back soon.
General Safety Note
Always consult a qualified healthcare professional before combining research compounds. Interactions may exist that are not yet documented.
$129.00
$0.1290
1
1
powder
| Vendor | Product | Form | Qty | Price | $/mg | Coupon | |
|---|---|---|---|---|---|---|---|
 |
Acetyl Hexapeptide-8 Raw 1g | powder | 1g● In Stock | $129.00BEST | $0.129 | — |
Tracking since Apr 22, 2026 · 1 data point
Vendors Selling Acetyl Hexapeptide-8
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Every supplier above is graded 0–100 on COA verification, payment transparency, shipping, reviews, and active listings. Methodology published, no pay-to-rank.
Related Compounds
View AllAHK-Cu
Skin & HairPreclinicalAHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper).
Melanotan 2
Skin & HairPhase IIA synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression..
Minoxidil
Skin & HairPreclinicalFDA-approved topical vasodilator used for hair regrowth.
PDRN
Skin & HairPhase 4PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation.
Snap-8
Skin & HairPreclinicalSnap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox).
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Protocols, calculator & safety for Acetyl Hexapeptide-8
Research Score
0 PubMed studies
Quality Indicators
Data Completeness
63%Quick Facts
Half-Life
Short (topical application, no systemic absorption at cosmetic doses)
Administration
Topical
Trial Phase
Preclinical
Safety Profile
Common Side Effects
- • Well tolerated in clinical cosmetic literature
- • Mild transient erythema at high concentrations
Research Disclaimer
This information is for educational and research purposes only. Not intended as medical advice. Consult a healthcare professional before use.
Frequently Asked Questions
What is Acetyl Hexapeptide-8 used for in research?
Acetyl Hexapeptide-8 (INCI: Acetyl Hexapeptide-3 in older nomenclature, commercially known as Argireline) is a synthetic hexapeptide designed as a competitive inhibitor of the SNARE complex at the neuromuscular junction. Its amino acid sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) mimics the N-terminal fragment of SNAP-25 — the same molecular target as Snap-8 but as a hexapeptide rather than octapeptide. Argireline is the most widely studied and commercially established topical anti-wrinkle peptide, with multiple in vitro and clinical trials demonstrating reduction in expression wrinkle depth of 17–48% at concentrations of 5–10%. It is commonly used in cosmetic compounding research in high-purity powder form for custom formulation.
What forms does Acetyl Hexapeptide-8 come in?
Acetyl Hexapeptide-8 is available in powder form.
How much does Acetyl Hexapeptide-8 cost?
Prices start at $129.00 across 1 verified vendor.
How do I compare Acetyl Hexapeptide-8 vendors?
Compare prices, payment methods, shipping, and COA scores across 1 vendor.
Research Tools
Related Compounds
View AllAHK-Cu
Skin & HairPreclinicalAHK-Cu (Ala-His-Lys-Copper) is a copper chelating tripeptide related to but distinct from GHK-Cu (Gly-His-Lys-Copper).
Melanotan 2
Skin & HairPhase IIA synthetic melanocortin receptor agonist studied for skin tanning, sexual function, and appetite suppression..
Minoxidil
Skin & HairPreclinicalFDA-approved topical vasodilator used for hair regrowth.
PDRN
Skin & HairPhase 4PDRN (Polydeoxyribonucleotide) is a biotechnological compound derived from salmon sperm DNA (Oncorhynchus mykiss) through extraction, purification, and fractionation.
Snap-8
Skin & HairPreclinicalSnap-8 (INCI: Acetyl Glutamyl Heptapeptide-1) is a synthetic octapeptide designed as an analog of the N-terminal fragment of synaptosomal-associated protein of 25 kDa (SNAP-25), which is the molecular target of botulinum toxin A (Botox).
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