SS-31 vs NAD+
Side-by-side comparison of SS-31 and NAD+: mechanism, half-life, dose range, safety profile, and vendor pricing.
Price snapshot
SS-31
NAD+
SS-31
SS-31 (elamipretide; MTP-131; formerly Bendavia; chemical sequence D-Arg-Dmt-Lys-Phe-NH2 with dimethyltyrosine at position 2) is a first-in-class aromatic-cationic tetrapeptide designed to selectively target the inner…
Lowest listed price: $72.00 across 4 listings
Full SS-31 profileNAD+
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a pyridine dinucleotide coenzyme essential to energy metabolism, DNA repair via PARP enzymes, sirtuin-mediated gene regulation, and calcium signaling via CD38.…
Lowest listed price: $25.00 across 11 listings
Full NAD+ profileSide-by-side comparison
| Attribute | SS-31 | NAD+ |
|---|---|---|
| Category | Mitochondrial Peptides | Longevity |
| Research Stage | Clinical/Approved | Phase II |
| Mechanism of Action | SS-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high concentration of cardiolipin, a signature mitochondrial anionic phospholipid - to… | Redox Cofactor Function NAD+ serves as the primary electron acceptor in catabolic reactions (glycolysis, TCA cycle, fatty acid oxidation), cycling between its oxidized (NAD+) and reduced (NADH) forms. This fundamental energy metabolism role means every cell… |
| Half-Life | ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding | Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent |
| Typical Dose Range | 20-60 mg | Oral precursors: NR 300-2,000 mg/day, NMN 250-900 mg/day, NAM 500-1,500 mg/day; IV NAD+ 500-1,500 mg per session. |
| Dosing Frequency | Once daily subcutaneous (some protocols use 5-6 days per week) | Oral precursors once daily (higher doses split AM/midday); IV NAD+ weekly-to-monthly at clinics. |
| Administration | — | Oral (precursors), Intravenous, Intramuscular, Subcutaneous |
| Side Effects | SS-31 (elamipretide) has been generally well-tolerated across clinical trials spanning over a decade of human exposure, with adverse event profiles dominated by injection site reactions rather than systemic toxicity. This favorable safety profile reflects both… | Nicotinamide Riboside (NR) NR has the best-characterized safety profile of the NAD+ precursors. Across published RCTs at 1,000-2,000 mg/day for up to 12 weeks, adverse effects have been mild and uncommon: - Gastrointestinal upset (5-10% of users) - Mild… |
| Molecular Weight | 639.8 g/mol | 663.4 g/mol (NAD+); NR 255.3 g/mol; NMN 334.2 g/mol; NAM 122.1 g/mol |
| Common Vial Sizes | — | 100mg, 250mg, 500mg |
Price History
2 data points- Ion Peptide
- BHG Labs
Price History
4 data points- OF
- BM
- Half Nattys
- Ion Peptide
- BHG Labs
SS-31: potential benefits
- No structured benefit list published.
NAD+: potential benefits
- Restores age-associated NAD+ decline — 50% loss between young and older adulthood
- Whole-blood NAD+ up 22, 51 and 142 percent at 100, 300 and 1,000 mg NR a day in an 8-week trial (Conze 2019, PMID: 31278280)
- Supports sirtuin-mediated gene regulation and PARP-mediated DNA repair
- Improves muscle insulin sensitivity in prediabetic postmenopausal women (Yoshino 2021)
- Increases aerobic performance in amateur runners at 300-600 mg NMN (Liao 2021)
- IL-6, IL-5 and IL-2 lower than baseline after 21 days of NR in 12 older men (PMID: 31412242)
- Brain NAD+ elevation demonstrated in Parkinson trial (Brakedal 2022)
- Excellent safety profile at evidence-supported doses (500-2000 mg/day NR)
Frequently asked
What's the difference between SS-31 and NAD+?
SS-31 is a mitochondrial peptides that ss-31's mechanism of action is distinctive among mitochondrial interventions because it exploits a fundamental physical property of the inner mitochondrial membrane - the high…. NAD+ is a longevity that redox cofactor function nad+ serves as the primary electron acceptor in catabolic reactions (glycolysis, tca cycle, fatty acid oxidation), cycling between its oxidized (nad+) and…. The two differ in mechanism, half-life (~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding vs Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent), and typical dose range.
Which has the longer half-life, SS-31 or NAD+?
SS-31 has a half-life of ~2-4 hours (plasma, after subcutaneous injection); tissue residence is longer due to cardiolipin binding. NAD+ has a half-life of Varies by form: NR ~8 hours plasma; NMN ~1-2 hours plasma; IV NAD+ infusion dose-dependent. Longer half-lives generally mean less frequent dosing but slower on/off kinetics.
Which is cheaper, SS-31 or NAD+?
Lowest listed price on BodyHackGuide: SS-31 from $72.00, NAD+ from $25.00. Prices are pulled from the vendor listings tracked on BHG and change frequently. See the compare tables on each compound page for the current set of offers.
Can you stack SS-31 and NAD+?
Stacking depends on mechanism overlap, safety profile, and goals. SS-31 and NAD+ should only be stacked after reviewing each compound's individual protocol page, side effect profile, and any published interaction data. Use the BodyHackGuide stack builder for a structured review before combining research compounds.
See current vendor prices
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Related comparisons
Research use only. BodyHackGuide is a research and price-comparison reference. The compounds discussed on this page are not approved by the FDA for human consumption and are sold strictly for laboratory research. Prices shown are pulled from vendor listings tracked on BHG and are subject to change. Every vendor is ranked on the same public, reproducible methodology. See editorial standards and affiliate disclosure.